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» LymeNet Flash » Questions and Discussion » Medical Questions » Has anyone noticed manic behavior in their kids from taking artemisinin?

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Author Topic: Has anyone noticed manic behavior in their kids from taking artemisinin?
tick battler
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I am not sure but I think it is possible that artemisinin is causing manic, hyperactive, oppositional behavior in one of my 5 year old boys. I had stopped pulsing it for two weeks b/c I was frightened by my other son's sudden allergy to it.

Since stopping the art, I have noticed that he has been much improved these past two weeks compared to his usual very difficult behavior.

But I noticed him becoming seemingly more tired so I started it up again this week. Today and yesterday he was very hyperactive and difficult.

I am very suspicious now of the artemisinin. I guess I am also hoping it is the art rather than him backsliding. I have been pretty down the past couple days about this apparent regression.

I am wondering if artemisinin has caused manic behavior for anyone else?

Thanks,

tickbattler

Posts: 1763 | From Malvern, PA | Registered: Jul 2009  |  IP: Logged | Report this post to a Moderator
Erica741
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Can you take out "kids" from the title of your post so I don't feel so ridiculous? :-)

Seriously, I got REALLY ramped up on even low doses of artemisinin and it didn't improve with time. Often the ramped up feeling would give me anxiety or even worse, major agitation/irritability.

If your son is experiencing anything like I did, I would expect his behavior to be difficult and erratic.

According to my new LLMD, many patients get neuro-toxic reactions to artemisinin and so he'll instead put us whole Artemisia annua capsules. I've been taking since July and it's been MUCH easier to tolerate.

Nutricology makes a good Artemisia product.

Posts: 408 | From California | Registered: Apr 2008  |  IP: Logged | Report this post to a Moderator
Marnie
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Couldn't bring up the abstract, but this is curious (I have an ADHD son):

"Quantitative in vivo and in vitro sex differences in artemisinin metabolism in rat"

Translation: boys and girls break down that herb at different rates.

******


It is an anti-cholinergic (!):

"http://www.ionchannels.org/showabstract.php?pmid=17675799

When reading the above...K = potassium, ACh = ACETYLCHOLINE.

****

"inhibition of GLU release brought about by ACh."

http://jpet.aspetjournals.org/cgi/content/abstract/248/3/1255

(reverse that...if acetylcholine is inhibited via artemisinin, does this -> more glutamate -> hyperactivity?

More about artemisinin:

From natural to man-made drug:

"Coartem, a malaria drug whose potency is derived from a Chinese herb, may soon be approved for sale in the United States.

Coartem, derived from the Chinese herb artemisinin, wipes out malaria in more than 96 percent of patients in regions where malaria has become resistant to older drugs, according to drug-maker Novartis."

http://www.scientificamerican.com/article.cfm?id=artemisinin-coartem-malaria-novartis

Unfortunately the buggers can mutate faster than we can develop drugs:

"ARC3 researchers pile on evidence of artemisinin resistance at Thai-Cambodia border"
7 Aug 2009

"Thus, artemisinin appears to be a potent auto-inducer of drug metabolism in rats as has also been observed in humans"

http://cat.inist.fr/?aModele=afficheN&cpsidt=14089695

"Artemisinin has a short elimination half-life, a rapid onset of action, no major side effects, and

***markedly induces of its own metabolic elimination,***

resulting in five- to sevenfold ***decreases*** in its concentrations over 5 to 7 days of administration in both malaria patients and healthy subjects."

http://aac.asm.org/cgi/content/full/46/4/1026

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tick battler
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Thank you both for your replies!

tickbattler

Posts: 1763 | From Malvern, PA | Registered: Jul 2009  |  IP: Logged | Report this post to a Moderator
   

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