LymeNet Flash: Emergence of Chronic Lyme Arthritis: Putting the Breaks on CD28 Costimulation.

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»	LymeNet Flash » Questions and Discussion » Medical Questions » Emergence of Chronic Lyme Arthritis: Putting the Breaks on CD28 Costimulation.

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Topic: Emergence of Chronic Lyme Arthritis: Putting the Breaks on CD28 Costimulation.

Melanie Reber
Frequent Contributor (5K+ posts)
Member # 3707

posted

Title
Emergence of Chronic Lyme Arthritis: Putting the Breaks on CD28 Costimulation.

Author(s) Iliopoulou BP, Huber BT

Institution Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts, USA.

Source Immunopharmacol Immunotoxicol 2008 Sep 15.:1-12.

Abstract
Lyme disease is a debilitating infection that is caused upon a bite of Borrelia burgdorferi (Bb)-infected ticks. One of the most prominent clinical manifestations is the development of chronic Lyme arthritis. Months after Bb infection, approximately 60% of untreated Lyme patients experience intermittent arthritic attacks that may last for years.

The use of the CD28(-/-) mouse in Bb infection has helped to shed light into the mechanisms that govern this inflammatory process, which seems to be tightly regulated. In this current review, the effect of immunoregulation, as well as CD28 deficiency in the development of chronic Lyme arthritis is discussed.

Language ENG

Pub Type(s) JOURNAL ARTICLE

PubMed ID 18792834

Posts: 7052 | From Colorado | Registered: Mar 2003 | IP: Logged |

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