The bioavailability of Mepron is increased approximately 3-fold when administered with meals. In particular, fat has been shown to enhance absorption significantly.
In one study, 18 volunteers received a single dose of 500 mg Mepron after an overnight fast and following a breakfast (23 g fat: 642 kCal). The mean (�SD) AUC values were 93.8�45.7 and 288�77 hr μg/mL, under fasting and fed conditions, respectively.
In another volunteer study where Mepron was administered under fasting conditions, with 28 g butter (23 g fat) and 56 g butter (46 g fat) on toast, mean AUC values increased 2.7- and 4.0-fold, respectively, compared to the fasting state.
Joe
Posts: 249 | From Northern NJ | Registered: Jul 2005
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