Differential scanning calorimetry provides a new window into the plasma proteome.
Plasma from normal individuals yields a characteristic, reproducible thermogram that appears to represent the weighted sum of denaturation profiles of the most abundant constituent plasma proteins.
Plasma from diseased individuals yields dramatically different signature thermograms.
Thermograms from individuals suffering from Rheumatoid arthritis, systemic lupus and Lyme disease were measured.
Each disease appears to have a distinctive and characteristic thermogram. The difference in thermograms between normal and diseased individuals is not due to radical changes in the concentrations of the most abundant plasma proteins, but rather appears to result from interaction of as yet unknown biomarkers with the major plasma proteins. These results signal a novel use for calorimetry as a diagnostic tool.
Posts: 180 | From UK | Registered: Nov 2005
| IP: Logged |
The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:
The
Lyme Disease Network of New Jersey 907 Pebble Creek Court,
Pennington,
NJ08534USA http://www.lymenet.org/