lymeladyinNY
Frequent Contributor (1K+ posts)
Member # 10235
posted
I went in for my upper endoscopy on Christmas eve. The pictures show inflamed spots all over the inside of my stomach.
The lovely thing is that the nurse told me I could go home - that I didn't need to see the doctor. She didn't know where he'd run off to, anyway.
I told her I was staying until the doctor talked to me. When he did he was all smiles. Yes, he did a biopsy, the results will be in next week. Here's a prescription for bentyl. No need for follow-up.
I felt like crying (as I usually do when dealing with doctors). I was not given any advice about how to eat as I wait during this week. And do you think he'd give me time to ask before walking out of the room?
Everything that goes into my stomach kills me. I've been researching and I'm trying to eat all fruits for three days, and then hopefully move on to some more foods.
I had Christmas dinner with my husband's family and I had vegetables while everyone else was eating lasagna! I felt so deprived.
I'll have to wait for the results of the biopsy to see what I have to do to get better. I had been taking a lot of advil for the stomach pain (duh!) and now, after research, I learn that it's one of the causes of gastritis!
I am also wondering if it isn't mepron that may have either caused or aggravated the situation. I've stopped all tick-borne disease treatments for now.
Probably in a week I'll be falling flat on my face over and over again like I usually do when babs starts to take over. Sigh.
I'll let you know the cause of the gastritis when I get the results.
Thanks for listening! - Lymelady
-------------------- I want to be free Posts: 1170 | From Endicott, NY | Registered: Sep 2006
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AZURE WISH
Frequent Contributor (1K+ posts)
Member # 804
posted
lymelady
I hope you get some answers (and more importantly some relief) soon.
lpkayak
Honored Contributor (10K+ posts)
Member # 5230
posted
i know exactly how you feel about the doc. mine didi the samw thing. refuses to talk to me unless i am doped up before or after a procedure. and then doesn't have anything to say. it's like the back doc. if there isn't something requireing an expensive surgery for them to make big bucks they don't want anything to do with you.
when i am at my worse i eat rice and boiled chic with some steamed vegies-3 meals a day like that. not fun. but less pain. good lucke.
-------------------- Lyme? Its complicated. Educate yourself. Posts: 13712 | From new england | Registered: Feb 2004
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hiker53
Frequent Contributor (5K+ posts)
Member # 6046
posted
Now if I have to a have procedure like an endoscopy, I write a list of questions and leave with the nurse for the doctor to answer, before he takes off while I am still doped up.
Hiker53
-------------------- Hiker53
"God is light. In Him there is no darkness." 1John 1:5 Posts: 8918 | From Illinois | Registered: Aug 2004
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bettyg
Unregistered
posted
best wishes on the results of endo... glad you waited there for him to get some answers.
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Yes, please let us know. I have no suggestions as to what best to eat. Did you ask for H. Pylori test?
You might want to try Prilosec - a proton inhibitor to ease the gastric pain and discomfort. Check with your doctor if it would be okay.
You can buy it over the counter - tho Rx'd strength is better. Here's some information to consider.
Proton pump inhibitor From Wikipedia, the free encyclopedia
Proton pump inhibitors (or "PPI"s) are a group of drugs whose main action is pronounced and long-lasting reduction of gastric acid production.
They are the most potent inhibitors of acid secretion available today.
The group followed and has largely superseded another group of pharmaceuticals with similar effects, but different mode-of-action, called H2-receptor antagonists.
These drugs are among the most widely-selling drugs in the world as a result of their outstanding efficacy and safety.
[1] Structurally, the vast majority of these drugs are benzimidazole derivatives; however, promising new research indicates that imidazopyridine derivatives may be a more effective means of treatment.[citation needed]
Contents [hide] 1 Clinical use 2 Mechanism of action 2.1 Potassium-competitive acid blockers (P-CABs) 3 Pharmacokinetics 4 Examples of proton pump inhibitors 5 Adverse effects
These drugs are utilized in the treatment of many conditions such as:
Dyspepsia
Peptic ulcer disease (PUD)
Gastroesophageal reflux disease (GORD/GERD)
Laryngopharyngeal Reflux Disease
Barrett's esophagus
prevention of stress gastritis
Gastrinomas and other conditions that cause hypersecretion of acid
Zollinger-Ellison syndrome
Despite their widespread use for these conditions, proton pump inhibitors effectiveness has not been demonstrated in every case.
For example, proton pump inhibitors do not change the length of Barrett's esophagus. [2] [edit] Mechanism of action Proton pump inhibitors act by irreversibly blocking the hydrogen/potassium adenosine triphosphatase enzyme system
(the H+/K+ ATPase, or more commonly just gastric proton pump) of the gastric parietal cell.
The proton pump is the terminal stage in gastric acid secretion, being directly responsible for secreting H+ ions into the gastric lumen, making it an ideal target for inhibiting acid secretion.
("Irreversibility" refers to the effect on a single copy of the enzyme;
the effect on the overall human digestive system is reversible, as the enzymes are naturally destroyed and replaced with new copies.)
Targeting the terminal-step in acid production, as well as the irreversible nature of the inhibition,
result in a class of drugs that are significantly more effective than H2 antagonists and reduce gastric acid secretion by up to 99%.
The lack of the acid in the stomach will aid in the healing of duodenal ulcers, and reduces the pain from indigestion and heartburn, which can be exacerbated by stomach acid.
However, lack of stomach acid is also called hypochlorhydria, the lack of sufficient hydrochloric acid, or HCl.
Hydrochloric acid is required for the digestion of proteins and for the absorption of nutrients, particularly of vitamin B12 and of calcium.
The proton pump inhibitors are given in an inactive form.
The inactive form is neutrally charged (lipophilic) and readily crosses cell membranes into intracellular compartments
(like the parietal cell canaliculus) that have acidic environments.
In an acid environment, the inactive drug is protonated and rearranges into its active form.
As described above, the active form will covalently and irreversibly bind to the gastric proton pump, deactivating it.
[edit] Potassium-competitive acid blockers (P-CABs) Potassium-competitive inhibitors are experimental drugs which reversibly block the potassium binding site of the proton pump.
Soraprazan and revaprazan block H+ secretion much more quickly than classical PPIs (within half an hour).
The development of soraprazan, however, has been discontinued in 2007.[4]
[edit] Pharmacokinetics Generally, the absorption of proton pump inhibitors is unaffected by co-administration with food.
The rate of omeprazole absorption, however, is decreased by concomitant food intake. Additionally, the absorption of lansoprazole and esomeprazole is decreased and delayed by food.
These pharmacokinetic effects, however, reportedly have no significant impact on efficacy.[5][6]
The elimination half-life of proton pump inhibitors ranges from 0.5-2 hours,
however the effect of a single dose on acid secretion usually persists up to 2-3 days.
This is because of accumulation of the drug in parietal cell canaliculi and the irreversible nature of proton pump inhibition.
[edit] Examples of proton pump inhibitors
The proton pump inhibitor Omeprazole.Clinically used proton pump inhibitors:
Decreased vitamin B12 absorption may occur with long-term use.[7]
Rarely PPI cause `idiosyncratic' reactions such as erythema multiforme, pancreatitis, Stevens Johnson syndrome and acute interstitial nephritis. [8]
It has been observed that gastric acid suppression,
using H2-receptor antagonists and proton pump inhibitors, is associated with an increased risk of community-acquired pneumonia.
It is suspected that acid suppression results in insufficient elimination of pathogenic organisms.
It has therefore been suggested that patients at higher risk of pneumonia should only be prescribed proton pump inhibitors at lower doses and only when necessary. [9]
PPIs have also been shown to raise risk of Clostridium difficile infection.[10]
Long-term use of proton pump inhibitors has been less studied.
But in a study of 135,000 people 50 or older, those taking high doses of PPIs for longer than one year have been found to be 2.6 times more likely to break a hip.
Those taking smaller doses for 1 to 4 years were 1.2 to 1.6 times more likely to break a hip.
The risk of a fracture increased with the length of time taking PPIs.[11]
Theories as to the cause of the increase are the possibility that the reduction of stomach acid reduces the amount of calcium dissolved in the stomach
or that PPIs may interfere with the breakdown and rebuilding of bone by interfering with the acid production of osteoclasts.[12]
Also, the reduction of vitamin B12 (by raising homocysteine) may increase bone fragility, an effect that may be offset by the consumption,
or by the co-packaging, of about 100 mcg of B12 with the PPI.
A recent study has also suggested that proton pump inhibitors significantly decreased the effect of clopidogrel on platelets as tested by VASP phosphorylation.
The clinical impact of these results must be assessed by further investigations,
but a PPI treatment should not be added to the antiplatelet dual therapy without formal indication.[13]
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