Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
By virtue of its PKC (calcium activated protein kinase) INHIBITOR...Bb is "assured" Ca will go in the cell (as a defense).
It does look to USE Ca (and then export it).
This is how it may temporarily use Ca:
Bb has a gene to metabolize arginine and proline i.e., break them down:
Gene Name: BB0841
EC Number: 3.5.3.6
Organism: Borrelia burgdorferi B31
*Putative* Identity: arginine deiminase
Arginine deiminase is a calcium dependent enzyme.
This enzyme participates in arginine AND proline metabolism.
An arginine deiminase is an enzyme that catalyzes the chemical reaction
L-arginine + H2O L-citrulline + NH3
NH3 is(ammonia!)
"Arginine deiminase (ADI) is known to be an inducer of apoptosis in vitro and an anti-tumor agent in vivo in some cancers.
ADI causes the enzymatic *depletion of arginine* which may
inhibit nitric oxide (NO) synthesis."
TNF alpha AND IL1 B look to increase NO synthesis - to counter too little NO being produced because Bb is breaking down/using L-arginine?
How to counter the ammonia?
*Zeolites*, montmorillonite and Bentonite (which is primarily montmorillonite) clays actually chemically bind ammonia molecules. This binding process is called adsorption.
OR...
When ammonia levels go too high in liver patients, they are given "Lactulose" (also called "Enulose").
Lactulose is a liquid laxative that binds with Ammonia to remove it from a person's system.
High ammonia levels can cause everything from dementia, drunkenness, slurred speech.....to coma, and even death.
Or???
Magnesium chloride has shown promise as a storage material for hydrogen. Ammonia, which is rich in hydrogen atoms, is used as an intermediate storage material.
Ammonia can be effectively adsorbed onto solid magnesium chloride, forming Mg(NH3)6Cl2.
Ammonia is released by mild heat, and is then passed through a catalyst to give hydrogen gas.
*********
If Bb IS metabolizing arginine (and proline), it would not make sense that the herpes viruses would re-activate since they NEED arginine to replicate...if Bb is is the system and metabolizing/using arginine = not enough arginine for them to replicate?
HHV-6 (a herpes virus that literally all of us have in our systems) is thought to re-emerge and cause MS and the myelin sheath (insulation around the nerves which comes from cholesterol) is destroyed by a VIRUS (or excessive ROS?).
"Arrangement of Cholesterol Molecules in the Myelin Sheath"
Bb looks uses the cholesterol pathway to BUILD its cell walls and uses oxidative stress to destroy our cell walls (which are made of cholesterol).
High levels of Lysine have been used to put MS in remission (leads to high levels of cholesterol).
Zinc is also linked (to both) re: modulating GABA C.
And vitamin B6 (depletion) is also implicated as it binds to lysine and B6 needed by GAD (enzyme) for glutamate -> GABA.
Complex!
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