Topic: If NH3 is the "toxin" from the breakdown of proteins
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Bb looks to MAKE and
*USE/RELY ON NH3*...(via its Arginine deiminase gene)
NH3 is ammonia.
"NH3-dependent NAD synthetase"
Translation: to make NAD, we need NH3 = ammonia.
"Nicotinamide adenine dinucleotide (NAD) and its relative nicotinamide adenine dinucleotide phosphate (NADP) are two of the most important coenzymes in the cell."
"NAD participates in many redox reactions in cells, including those in
glycolysis and.."
Does Bb's own breakdown (when it is destroyed AND the once-infected protein rich defense cells are also destroyed) -> INCREASED NH3 and contribute to the "health" of its "youngins"?
"Ammonification: after death, breakdown of proteins into amino acids, then amino groups removed to form ammonia (NH3); caused by aerobic and anaerobic bacteria and fungi..."
Ann...if you are reading this...email me directly.
Can we get it down to 2 supplements?
Your "detox" and...
"secoisolariciresinol diglucoside"?
The cells that are functioning solely on glycolysis should be impacted the "hardest" if NH3 is lowered.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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TerryK
Frequent Contributor (5K+ posts)
Member # 8552
posted
I don't fully understand what you are saying. The only thing I'm getting out of it is that Bb and cell debri may cause increased ammonia and increased ammonia may contribute to the survival of Bb?
I don't see any products made of secoisolariciresinol diglucoside or what it is supposed to do specific to your post.
From wiki
"Animal studies have shown SDG can prevent the development of atherosclerosis and diabetes, and has beneficial modifying effect on blood and cholesterol levels."
What do you mean by this please? Is this a good thing? "The cells that are functioning solely on glycolysis should be impacted the "hardest" if NH3 is lowered."
If increased ammonia contributes to the health of Bb then seems like reducing ammonia would be helpful?
Some of us have trouble breaking down ammonia due to methylation cycle mutations. Specifically CBS upregulation and MTHFR A1298C. I have both.
BH4 is needed to break down ammonia. MTHFR A1298C mutation causes low BH4. Increased ammonia drains levels of BH4 and makes already low levels even lower.
Even if you don't have the mutations that cause low levels of BH4 - if you have high ammonia you may still have low BH4 because BH4 is used up to detoxify ammonia.
Low BH4 means more severe parasitic infections, difficulty deactivating viruses, diabetes, hypertension and arteriosclerosis. Serotonin synthesis requires BH4. Low BH4 will affect dopamine levels. Excess ammonia in the gut may alter gut PH and cause microbial imbalances.
Not sure how this fits into your NOS research but it may fit in there somewhere. See the following from my notes:
For anethesia - the availability of BH4 helps to determine whether nitric oxide, peroxy nitrite or super oxide are formed as a function of the urea cycle; two molecules of BH4 are required for the formation of nitric oxide, one molecule of BH4 leads to the formation of peroxy nitrite and the absence of BH4 leads to super oxide formation.
Some of the things that Dr. Yasko recommends for decreasing ammonia.
Charcoal flushes lower meat intake sprinkle yucca on meat when eating it. yuch! ARA 6 - larch powder RNA ammonia carnitine Butyrate
I take low dose BH4.
Dr. J. makes a product to decrease ammonia - I don't know much about it. L-ornithine can decrease ammonia.
Terry
Posts: 6286 | From Oregon | Registered: Jan 2006
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TerryK
Frequent Contributor (5K+ posts)
Member # 8552
posted
Here is what Dr. J. says about NH3. He uses unconventional test methods to find ammonia. Not saying it's wrong but just want to point that out to anyone who is reading this. http://abc.eznettools.net/jernigannutraceuticals/ammonia.html "Localized ammonia is present in virtually every chronic LD patient, either from the spirochete or other indirect mechanism.
We have found ammonia wherever Lyme spirochetes reside in the body, but primarily over the liver, heart, teeth, and cranium.
I must say that all of our LD patients are either on Borrelogen or Microbojen or both while taking the NeuroAntitox Formula and Pale-Spike Lobelia Extract (not to be confused with Lobelia inflata), as well as a strong systemic proteolytic enzyme supplement, such as Wobenzym-N, Nutrazyme, or Vitalzyme. Therefore, to reproduce our good results may require one to follow this type of protocol.
More on the Lyme toxin issue can be read in our new book, ``Beating Lyme Disease; Using Alternative Medicine and God-Designed Living.'' This is a hardback book with 410 pages, and can be ordered by calling toll free 877.456.8872 or through amazon.com. Your thoughts and comments are appreciated."
Posts: 6286 | From Oregon | Registered: Jan 2006
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