LymeNet Flash: Rationale behind pulsing with Zythro?

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»	LymeNet Flash » Questions and Discussion » Medical Questions » Rationale behind pulsing with Zythro?

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Topic: Rationale behind pulsing with Zythro?

trigal2
LymeNet Contributor
Member # 20578

posted

Hello All;

Questions for those who have experience pusling with Zythro.

Just got a call from the Nurse at my LLMD's office to start pulsing my Doxy. with Zythro twice a week. I asked her what the Zythro will do and she was not sure but said the Dr. wanted me to start this week. Dr. suppose to call later today to explain.

So, until she calls I was wondering how many other have pulsed with Zythro and what is the idea behind it?

Thanks in advance!

Posts: 376 | From New Jersey | Registered: Jun 2009 | IP: Logged |

kitty9309
LymeNet Contributor
Member # 19945

posted

One dose of azithromycin (Zithromax) renmains in your system for 68 hours. This is the half life.

"The prolonged terminal half-life is thought to be due to extensive uptake and subsequent release of drug from tissues."

Zithro is highly concentrated in your tissues and macrophages (type of white blood cell). It is actively transported to the site of infection.

It is a good drug for intracellular infections or those that hide out in deep tissues.

I take my Zith every other day.

Posts: 819 | From East Coast | Registered: Apr 2009 | IP: Logged |

sixgoofykids
Moderator
Member # 11141

posted

Zithro was a drug that was very difficult for me to take. My LLMD wanted me to reach full concentrations of it in my system, which takes a few days, so he had me pulse 3 days on 4 off. That way I had the break from the terrible herx it caused every time I took it for three days. There was no way I could take it continually.

Perhaps he's seeing how you react?

--------------------
sixgoofykids.blogspot.com

Posts: 13449 | From Ohio | Registered: Feb 2007 | IP: Logged |

MorningSong
LymeNet Contributor
Member # 19989

posted

LLMD has prescribed pulsing Zith and Omnicef for M W F.

Posts: 515 | From In His Loving Care | Registered: Apr 2009 | IP: Logged |

Lymetoo
Moderator
Member # 743

posted

You won't get well on doxy alone, so this is good!!

--------------------
--Lymetutu--
Opinions, not medical advice!

Posts: 96223 | From Texas | Registered: Feb 2001 | IP: Logged |

dguy
LymeNet Contributor
Member # 8979

posted

Some research says that maximum Bb killing occurs as the circulating abx level is decreasing. Pulsing doses takes advantage of this by ramping up the level followed by letting it settle.

Posts: 727 | From USA | Registered: Mar 2006 | IP: Logged |

FunkOdyssey
LymeNet Contributor
Member # 15855

posted

What research? Pubmed link?

Posts: 195 | From Manchester, CT | Registered: Jun 2008 | IP: Logged |

trigal2
LymeNet Contributor
Member # 20578

posted

Thanks everyone for your info.

I'm sure my LLMD will explain it all to me but I was very curious as to the difference between the way Doxy works vs. Zythro. It has been years since I had taken Zythro and will curious to see how I respond. Seems like this is a common protocol.. Thanks.

Posts: 376 | From New Jersey | Registered: Jun 2009 | IP: Logged |

dguy
LymeNet Contributor
Member # 8979

posted

quote:
Originally posted by FunkOdyssey:
What research? Pubmed link?

I've seen it published with MP stuff, and it may be elsewhere too. Afraid I don't have any links for you.

Posts: 727 | From USA | Registered: Mar 2006 | IP: Logged |

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