You can go there and type in Flagyl + cysts + Brorson. You can do the same for Tinidazole.
APMIS. 1999 Jun;107(6):566-76. An in vitro study of the susceptibility of mobile and cystic forms of Borrelia burgdorferi to metronidazole.
Brorson O, Brorson SH.
Department of Microbiology, Vestfold Sentralsykehus, T�nsberg, Norway.
The aim of this study was to examine the susceptibility of mobile and cystic forms of Borrelia burgdorferi to metronidazole. Because B. burgdorferi is a microaerobic bacterium like Helicobacter pylori, metronidazole (MZ) was chosen in the susceptibility test. For both microaerobic and aerobic incubation the normal mobile spirochetes were resistant to this antibiotic with an MBC > or = 512 microg/ml. Conversion of mobile spirochetes to cystic forms was not observed when they were incubated with MZ. When they were incubated under microaerobic conditions, the biologically active cystic forms had an MBC > or = 4 microg/ml, but the MBC was > or = 32 microg/ml with aerobic incubation at 37 degrees C. Staining with acridine orange (AO), dark field microscopy (DFM), and transmission electron microscopy (TEM) revealed that the contents of the cysts were degraded when the concentration of MZ was > or = MBC. Some cysts were also ruptured. When incubated with a sufficient concentration of MZ, core structures did not develop inside the cysts, and AO revealed less RNA in the cysts. Our observations may help efforts to treat resistant infections caused by B. burgdorferi with a combination of MZ and other antibiotics in order to eradicate both cystic and mobile forms of B. burgdorferi.
PMID: 10379684 [PubMed - indexed for MEDLINE]
MeSH Terms, Substances
Here is the one on Tinidazole:
Int Microbiol. 2004 Jun;7(2):139-42. An in vitro study of the susceptibility of mobile and cystic forms of Borrelia burgdorferi to tinidazole.
Brorson O, Brorson SH.
Department of Microbiology, Vestfold Sentralsykehus, T�nsberg, Norway.
The susceptibility of mobile and cystic forms of Borrelia burgdorferi to tinidazole (TZ) was examined. The minimal bactericidal concentration (MBC) of TZ against the mobile spirochetes was >128 microg/ml at 37 degrees C in micro-oxic atmosphere when incubated for 14 days. TZ significantly reduced the conversion of mobile spirochetes to cystic forms during incubation. The MBC for older (10-months-old) cysts at 37 degrees C in a micro-oxic atmosphere was >0.5 microg/ml, but >0.125 microg/ml for young (1-day-old) cysts. Acridine orange staining, dark-field microscopy and transmission electron microscopy revealed that, when the concentration of TZ was > or = MBC, the contents of the cysts were partly degraded, core structures did not develop inside the young cysts, and the amount of RNA in these cysts decreased significantly. When cysts were exposed to TZ, both the spirochetal structures and core structures inside the cysts dissolved, and the production of blebs was significantly reduced. These observations may be valuable in the treatment of resistant infections caused by B. burgdorferi, and suggest that a combination of TZ and a macrolide antibiotic could eradicate both cystic and mobile forms of B. burgdorferi.
PMID: 15248163 [PubMed - indexed for MEDLINE]
Posts: 5191 | From Lyme Zone | Registered: Jan 2009
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canefan17
Frequent Contributor (5K+ posts)
Member # 22149
posted
macrolide antibiotic?
I'm taking flagyl with doxy and plaquenil.
I took ceftin out for now.
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Abxnomore
Frequent Contributor (5K+ posts)
Member # 18936
posted
Some of those who went to ILADS conference reported that it was said that doxy and tinidazole was found to be a good combo.
You can check the posts about the conference for more info.
The above studies are not that new but do answer the poster's original question about flagyl.
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