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» LymeNet Flash » Questions and Discussion » Medical Questions » Benicar (Olmesartan)

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Author Topic: Benicar (Olmesartan)
Cold Feet
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Member # 9882

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I've always believed that Benicar is the cornerstone of the Marshall Protocol. This study is interesting, perhaps validating for some.

(Note that the mfr of Benicar is the study author.)

Neuroreport. 2009 Oct 28;20(16):1481-5.

Olmesartan medoxomil ameliorates sciatic nerve regeneration in diabetic rats.
Nakamura H, Domon Y, Inoue T, Arakawa N, Yokoyama T.

Biological Research Laboratories II, R&D Division Daiichi-Sankyo Co. Ltd., Tokyo, Japan.

To evaluate the effect of angiotensin II type1 receptor blocker on nerve regeneration delay in diabetic rats, nerve regeneration was monitored by a pinch test on the crushed sciatic nerves of streptozotocin-induced diabetic rats. Nerve regeneration was significantly delayed in diabetic rats and was partly ameliorated by treatment with olmesartan medoxomil (3 mg/kg/day, orally). In the ipsilateral dorsal root ganglia, the mRNA level of insulin-like growth factor-1 and ciliary neurotrophic factor (CNTF) was downregulated, whereas the mRNA level of neurotrophin-3 and CNTF receptor was upregulated.

Olmesartan medoxomil significantly enhanced the CNTF expression. These results showed that angiotensin II type1 receptor blocker treatment is effective on nerve regeneration delay in diabetic animals and may provide an effective therapy for clinical diabetic neuropathy.

PMID: 19786922 [PubMed - in process]

--------------------
My biofilm film: www.whyamistillsick.com
2004 Mycoplasma Pneumonia
2006 Positive after 2 years of hell
2006-08 Marshall Protocol. Killed many bug species
2009 - Beating candida, doing better
Lahey Clinic in Mass: what a racquet!

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coltman
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Interesting . Also http://www.ncbi.nlm.nih.gov/pubmed/9617544 . I wonder if that is one of the factors for light sensitivity
Posts: 856 | From MA | Registered: Jul 2009  |  IP: Logged | Report this post to a Moderator
Cold Feet
LymeNet Contributor
Member # 9882

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Hey Colt, thx for the link. I don't see the connection -- can you help me understand what you had in mind?

[Wink]

--------------------
My biofilm film: www.whyamistillsick.com
2004 Mycoplasma Pneumonia
2006 Positive after 2 years of hell
2006-08 Marshall Protocol. Killed many bug species
2009 - Beating candida, doing better
Lahey Clinic in Mass: what a racquet!

Posts: 830 | From Mass. | Registered: Aug 2006  |  IP: Logged | Report this post to a Moderator
   

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