Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
Could this be why our coinfections are often suppressed and then emerge when one is treated?
"Therefore, we conclude that ongoing infection with B. microti parasites leads to suppression of the malaria infection."
Infect Immun. 2010 Jan 4. [Epub ahead of print]
Suppression of Plasmodium cynomolgi in rhesus macaques by co-infection with Babesia microti. van Duivenvoorde LM, Voorberg-van der Wel A, van der Werff NM, Braskamp G, Remarque EJ, Kondova I, Kocken CH, Thomas AW.
Department of Parasitology and Department of Animal Science, Biomedical Primate Research Centre, Rijswijk, the Netherlands.
Plasmodium and Babesia species are both intra-erythrocytic protozoa that infect a wide range of hosts, including humans, eliciting similar inflammatory responses and clinical manifestations showing markedly different degrees of severity. We recently reported that a rhesus macaque, chronically infected with Babesia microti, was better able to control infection with Plasmodium cynomolgi (a parasite of macaques with characteristics closely similar to P. vivax) than na�ve monkeys. To confirm this and investigate the underlying immunopathology, six na�ve rhesus monkeys were infected with B. microti. After 24 days, 4 of these monkeys and 4 na�ve rhesus monkeys were challenged with P. cynomolgi blood stage parasites. B. microti persisted at low levels in all monkeys, and clinical parameters were comparable to non-infected controls. There was a significant decrease in P. cynomolgi parasitaemia in animals co-infected with B. microti compared to those infected with P. cynomolgi alone. This decrease in P. cynomolgi parasitaemia correlated with an increase in pro-inflammatory monocytes at the time of P. cynomolgi infection and more elevated CRP serum levels one week after malaria infection. Therefore, we conclude that ongoing infection with B. microti parasites leads to suppression of the malaria infection.
PMID: 20048045 [PubMed - as supplied by publisher]
cactus
Frequent Contributor (1K+ posts)
Member # 7347
posted
Thanks for posting this!
Gave me an a-ha moment. I think it's an important piece of the puzzle.
-------------------- �Did you ever stop to think, and forget to start again?� - A.A. Milne Posts: 1987 | From No. VA | Registered: May 2005
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