Bugg
Frequent Contributor (1K+ posts)
Member # 8095
posted
Does anyone have access to the full text of the following study??? I'd love to know who they classify as "immunocompromised".....
Emergence of resistance to azithromycin-atovaquone in immunocompromised patients with Babesia microti infection. Wormser GP, Prasad A, Neuhaus E, Joshi S, Nowakowski J, Nelson J, Mittleman A, Aguero-Rosenfeld M, Topal J, Krause PJ. Clinical Infectious Diseases, 2010 Feb 1;50(3):381-6.
BACKGROUND: Babesiosis is an emerging tickborne malaria-like infection principally caused by Babesia microti. This infection typically resolves either spontaneously or after administration of a 7-10-day course of azithromycin plus atovaquone or clindamycin plus quinine. Although certain highly immunocompromised patients may respond suboptimally to these drug regimens, unlike the situation with malaria there has been no reported evidence that the cause of treatment failure is infection with drug-resistant strains of B. microti.
METHODS: Emergence of drug resistance in B. microti was defined as the development of a microbiologic relapse (recurrent parasitemia or a marked increase in parasitemia) in association with both clinical and laboratory abnormalities indicative of active babesiosis in a patient after 28 days of uninterrupted antibabesia drug therapy and while still receiving treatment.
RESULTS: The clinical case histories of 3 highly immunocompromised patients who received a subcurative course of azithromycin-atovaquone associated with the eventual development of resistance to this drug regimen are described. One of the 3 patients died of complications related to babesiosis.
CONCLUSIONS: B. microti may become resistant to azithromycin-atovaquone during the treatment of babesiosis with this combined drug regimen in highly immunocompromised patients. Although research is needed to determine the optimal therapy for highly immunocompromised patients with babesiosis, reducing the level of immunosuppression when possible would appear to be a desirable strategy.
canefan17
Frequent Contributor (5K+ posts)
Member # 22149
posted
"Reducing the level of immunosuppression when possible would appear to be a desirable strategy."
Derrrrrrrrrrrrrrrrrrrrrrrr
This is probably why a lot of LLMD's like to use arteminisin a month or so after starting Zithro-Mepron.
Posts: 5394 | From Houston, Tx | Registered: Aug 2009
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seekhelp
Frequent Contributor (5K+ posts)
Member # 15067
posted
Why don't these people gets off their butts and study WA-1?
Posts: 7545 | From The 5th Dimension - The Twilight Zone | Registered: Mar 2008
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Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
Because they have ulterior motives. Deny treatment for over 4 weeks by saying bugs may build
resistance. Lest we cannot imagine we have other infections also in compromised individuals. They waste our time.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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