CD57
Frequent Contributor (1K+ posts)
Member # 11749
posted
Study Title: Effect of ciprofloxacin (Cipro) and N-acetylcysteine (NAC) on bacterial adherence and biofilm formation on ureteral stent surfaces.
Study Abstract:
The aim of this study was to evaluate the effect of ciprofloxacin (CIP), N-acetylcysteine (NAC) alone and in combination on biofilm production and pre-formed mature biofilms on ureteral stent surfaces. Two strains each of Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebseilla pneumoniae, Pseudomonas aeruginosa and Proteus vulgaris, recently isolated from patients undergoing ureteral stent removal and shown to be capable of biofilm production, were used in this study. The inhibitory effects of ciprofloxacin, N-acetylcysteine and ciprofloxacin/N-acetylcysteine combination were determined by static adherence assay. Ciprofloxacin (MIC and 2 MIC) and N-acetylcysteine (2 and 4 mg/ml) inhibited biofilm production by > or = 60% in all tested microorganisms.
Disruption of pre-formed biofilms of all tested microorganisms was found to be > or = 78% in the presence of ciprofloxacin (MIC and 2 MIC) and > or = 62% in the presence of N-acetylcysteine (2 and 4 mg/ml), compared to controls.
Ciprofloxacin/N-acetylcysteine showed the highest inhibitory effect on biofilm production (94-100%) and the highest disruptive effect on the pre-formed biofilms (86-100%) in comparison to controls. N-acetylcysteine was found to increase the therapeutic efficacy of ciprofloxacin by degrading the extracellular polysaccharide matrix of biofilms. These data are statistically significant.
The inhibitory effects of ciprofloxacin and N-acetylcysteine on biofilm production were also verified by scanning electron microscope (SEM). In conclusion, Ciprofloxacin/N-acetylcysteine combinations have the highest inhibitory effect on biofilm production and the highest ability to eradicate pre-formed mature biofilms.
Study Information:
El-Feky MA, El-Rehewy MS, Hassan MA, Abolella HA, Abd El-Baky RM, Gad GF. Effect of ciprofloxacin and N-acetylcysteine on bacterial adherence and biofilm formation on ureteral stent surfaces. Pol J Microbiol. 2009 September 58(3):261-7. Microbiology Department, Faculty of Medicine, Assuit University, Assuit, Egypt
Posts: 3528 | From US | Registered: Apr 2007
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Nice abstract CD 57. I have not yet tried NAC but may need to order some soon. Others seem to take NAC and Grape seed extract too. Time to go supplement shopping . . . again.
Beachinit.
-------------------- Ideas not advice. Posts: 448 | From Downeast Maine | Registered: Jul 2009
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lpkayak
Honored Contributor (10K+ posts)
Member # 5230
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does nac help without cipro?
-------------------- Lyme? Its complicated. Educate yourself. Posts: 13712 | From new england | Registered: Feb 2004
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karenl
Frequent Contributor (1K+ posts)
Member # 17753
posted
I have no idea but I know that people with chlamydia pneumonia take NAC to get the bug out of a crypt form to a form where it can be killed. They use NAC alone or later on with doxi. But I think you always need a killer in addition to NAC.
Posts: 1834 | From US | Registered: Oct 2008
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