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» LymeNet Flash » Questions and Discussion » Medical Questions » Antihistamines during Lyme treatment?

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Author Topic: Antihistamines during Lyme treatment?
Elizabeth S.
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Need help.

I have cyproheptadine, it's an antihistmaine among other things. I once read somwehere that lowering an allergic reaction with an antihistamine is also lowering your immune system which I don't want to do if my immune system si trying to fight the lyme bugs.. but i've only read that once and i don't even remember where.

Does anyone have more infromation (or just an answer) on whether it's wise to take antihistamines when on antibitoics to treat lyme? I don't want to lower anything but that may just be crazy talk anyway because i've heard of people using benadryll to lower herxing reactions and i know there a lot of people with concurrent Lyme + allergies...

Thank you ver y much, i don't have the energy to reserach this on my own right now

Elizabeth

[ 11-13-2009, 06:52 PM: Message edited by: Elizabeth S. ]

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joalo
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I've never heard that.

Sending this up for others with more knowledge than me.

--------------------
Sick since January 1985. Misdiagnosed for 20 years. Tested CDC positive October 2005. Treating since April 2006.

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Starfall1969
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I don't have the answer either, but I do take Benadryl for nausea and for shrtness of breath.
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Elizabeth S.
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Thank you both.

Cyproheptadine is an antihistamine and anticholinergic that your'e supposed to take 4mg every four hours...

I have extreme medicine sensitivity and can only take ONE FOURTH of that, 1mg, per 24 HOURS. When I put it like that I doubt there would be a problem even if antihistamines WERE bad during lyme treatment. But if anyone has infomration I'd still love to hear it. Thanks again

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Lymetoo
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I've heard of that, but I've always taken antihistamines anyway. Have to.

I don't think it has much effect on our immune systems.

--------------------
--Lymetutu--
Opinions, not medical advice!

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Elizabeth S.
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Self bump!
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Annelet
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I have come across that before as well ( about antihistamines depressing the immune system )

Antihistamines work differently to immune suppressing drugs. They block the H2 receptors and stop the histamine having an effect.

I have recently restarted treatment with Mepron, Zithromax, Bactrim and Plaquenil. herxing has been FIERCE for the last 2 weeks, but I was at the point of quitting because of the nausea. My LLMD suggests Zyrtec 10mg. What a difference!!!! The nausea is manageable, I am eating, but also I think that with the decrease in generalised inflammation, my meds are now getting into the tissues better.....I am mini-herxing again.

I am only taking 5mg, not 10mg. Even though it is the non-drowsy Reactine......I am SO relaxed and spaced out....like after a glass of wine or two!! Works for Me!!

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Keebler
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-
http://en.wikipedia.org/wiki/Cyproheptadine

Cyproheptadine - (. . . trade name Periactin) is an antihistaminic/anticholinergic and antiserotonergic agent. It acts as a 5-HT2 receptor antagonist as well and also blocks calcium channels.[1] . . .

. . . While not specifically used as a sedative, cyproheptadine causes drowsiness,[18] as is common with first-generation antihistamines.

Research has shown a suppression of growth hormone with doses of 8-12 mg per day taken for 5 days.[19]

Other common side effects include:[20]

Dizziness
Blurred vision
Constipation [poster's note: that will keep more toxins in your body]
Dry mouth, throat, or nose [poster's note: that can lead to mouth infections]
Excitability
Nausea
Nervousness
Restlessness . . . .

-==================

http://www.patient.co.uk/medicine/Cyproheptadine.htm

Before taking cyproheptadine make sure your doctor or pharmacist knows:

. . . If you suffer from liver, kidney or prostate problems

If you suffer from epilepsy, porphyria or glaucoma . . . .

=====================

http://flash.lymenet.org/ubb/ultimatebb.php/topic/1/91842

Porphyria as it may relate to lyme patients

======================

In trying to determine if this Rx uses the C P-450 liver detox pathway (which I suspect it does or there would not have been the porphyria warning in the UK site), I came upon this abstract.

Now, I have no idea what it means. It could say that this Rx either encourages - or discourages - yeast growth. But, I would want to know more about that.

http://www.ncbi.nlm.nih.gov/pubmed/9141237
Xenobiotica. 1997 Mar;27(3):301-15.

FUNGAL TRANSFORMATIONS OF ANTIHISTAMINES: metabolism of CYPROHEPTADINE hydrochloride by Cunninghamella elegans.

Zhang D, Hansen EB Jr, Deck J, Heinze TM, Henderson A, Korfmacher WA, Cerniglia CE.

Department of Health and Human Services, National Center for Toxicological Research, Jefferson, AS 72079, USA.


* Metabolites formed during incubation of the antihistamine cyproheptadine hydrochloride with the zygomycete fungus Cunninghamella elegans in liquid culture were determined.

. . . These results are consistent with the fungal epoxidation and hydroxylation reactions being catalysed by cytochrome P450 monooxygenases . . . .
-

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Robin123
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Doesn't make sense to me. Anti-histamines can lower allergic response and that's a good thing. I'm always having this kind of conversation with my LLMD, and it always seems to be a positive approach to be taking.
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Keebler
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-
There are many ways to lower inflammation to lesses a herx. If one is not right for you, there are other choices.

Magnesium and Fish oil are at the top of the list. Turmeric (and its stronger extract, Curcumin) are also very helpful.

A gluten-free diet lowers inflammation as does eating lots of colorful veggies and a moderate amount of low sugar fruits like dark berries and tart apples.

Liver support also helps to lower inflammation.

====================

This is included in Burrascano's Guidelines, but you may want to be able to refer to it separately, too:

http://www.lymepa.org/Nutritional_Supplements.pdf

** Nutritional Supplements in Disseminated Lyme Disease **

J.J. Burrascano, Jr., MD (2008) - Four pages

====================

Great information about treatments options and support measures:

http://tinyurl.com/6lq3pb (through Amazon)

THE LYME DISEASE SOLUTION (2008)

- by Kenneth B. Singleton , MD; James A. Duke. Ph.D. (Foreword)

You can read more about it here and see customer reviews.

Web site: www.lymedoctor.com

====================

http://www.tillotsoninstitute.com/important-herbs/turmeric-root-curcuma-longa.html

TURMERIC ROOT (Curcuma longa)

WHAT IT DOES: Turmeric root is bitter in taste and warming in action. It strongly reduces inflammation and mucus in all parts of the body, protects the liver, lungs and intestines . . . .

- full article at link above. From ``The One Earth Herbal Sourcebook'' (Tilltoson, et.al.)


================

http://tinyurl.com/y8bd9k2

Curcumin Prevents Some Stress-Related Changes

=================

http://www.ncbi.nlm.nih.gov/sites/entrez

PubMed Search:

Turmeric - 1517 abstracts

Curcumin - 3176 abstracts

Curcumin, diabetes - 113 abstracts

Curcumin, inflammation - 291 abstracts

Curcumin, adrenal - 18 abstracts

Curcumin, cardiac - 63 abstract
-

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Elizabeth S.
LymeNet Contributor
Member # 22405

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thanks for the recent information, all [Smile]
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