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» LymeNet Flash » Questions and Discussion » Medical Questions » mitochondrial damage by Bb?

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Author Topic: mitochondrial damage by Bb?
psano2
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I remember reading a long time ago that Bb damages the mito, and that's what causes the profound fatigue often experienced by Lyme patients, but I can't seem to find any scientific article that actually demonstrates that.

Can anyone help me w/a reference?

Thanks,

Patti

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psano2
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anyone?
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Marz
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I've wondered the same thing. Hope someone knows.

My PCP who was recommended by my LLMD told me I have a mitochondrial problem which is the reason for my fatigue. When I asked her what to about it she said she didn't know and gave me a hug!

Since my LLMD says I don't have lyme anymore, I'm wondering why the problem.

Or, do co-infections cause it too? Although I don't have any of those according to her.

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psano2
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Well, I know I read it somewhere, but was really surprised when I went to the LDA conference last week and asked Brian Fallon about it, and he said he didn't know anything about it... That was mystifying to me, so I thought I'd better really look for some hard data to support the idea, although it makes perfect sense and would account for the profound fatigue that we experience.

I guess if no one has a link to something, I'll have to go to the med library.

If it's been proven to interfere with mitochondrial production of ATP, then mitochondrial testing would be another marker to use for Lyme.

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Hoosiers51
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I don't know if this helps or not, but my chiropractor also said that antibiotics can CAUSE mitochondrial fatigue. Who knows if there is truth behind it.

I was just as fatigued if not moreso before I started my antibiotic therapy though, so that would be evidence against her theory, at least in my case.

Two good supplements for mitochondrial fatigue are "Mitochondrial Resusitate" by Metagenics (usually only available at chiropractors' offices, etc) (and it contains CoQ10 so no taking with Mepron or Malarone!) or NT Factor by Researched Nutritionals.

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Marz
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This isn't a scientific article, but at least it does verify that the spirochete does attack it.

http://www.lymeinfo.net/thiamin.html

Thanks for the idea for supplements Hoosier.

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hshbmom
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What test is used to confirm a clinical diagnosis of mitochondrial dysfunction?

Does any particular type physician deal with this symptom?

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back2game
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I found a piece on CFS - The Central Cause: Mitochondrial Failure From Doctor Myhill. www.drmyhill.co.uk/drmyhill/index

Let me know what you think. Thanks, Gin

--------------------
CNS Lyme 05/08 - EIA 1.16+, IGG 18+, IGM 23+
01/11-IGM 31 Epitope Positive
01/11-IGM 31+++, 41+, 58++, 83-93+, 23-25IND, 39IND
01/11-IGG 41+
Vasculitis 01/07,MCTD 05/06,Fibro 11/04, Myofascial PS 11/03
Embedded Tick app. 1990

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Keebler
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-
Yes, borrelia can cause severe damage to the mitochrondria. Other infections can do so, as well. Myhill has a very good take on the process - especially the fatigue from the mitochrondrial damage -- but her research (as I recall) does not make the lyme connection.

Some more discussion about mitochrondria is discussed here - with suggestions for what helps (d-Ribose; Hawthorn, etc.):
---------------

http://flash.lymenet.org/ubb/ultimatebb.php/topic/1/77325

Topic: To everyone with cardiac symptoms please read !

-

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Bugg
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Wow, I'm shocked Dr. Fallon has never looked into this....especially since so many of the supps most highly recommended for lyme patients support mitochondria(ATP).....Weird....
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psano2
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Bugg,

I'm surprised that you mention Dr. Fallon, because when I heard him speak a few years ago in San Francisco, I asked him about mitochondrial dysfunction causing Lyme fatigue, and he looked at me like I was nuts, and said he didn't know about that.

I think that's what made me start this thread to start with. Some people have said that it's a well known fact that Bb attacks mitochondria, but I couldn't find any scientific papers that support that.

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