posted
So, next appt, my doctor and I are going to address mitochondrial dysfunction. I was actually feeling pretty decent, and after this recent herx I am more fatigued than ever. I tried going to the grocery store today with my mother. I didn't make it very far, and was so warn out by the time I got back to the car. I am 24 and used to be highly athletic.
I am loaded with intracellular pathogens (as seen under live dark field microscopy) and it looks as if my body is trying to create new RBCs as quickly as it can (as evident by elevated bilirubin and small RDW sizes). Basophils, eosinophils, and neutrophils are elevated, but strange enough lymphs are low. I've been running low grade fevers (~99.5) on and off with some nasty (heart) herx symptoms. Does the stealing of nutrients and energy from cells by pathogens contribute or cause mitochondria dysfunction?
I don't know much about mitochondrial dysfunction, but wondering what people here generally take for mitochondrial repair. I did a search, and I don't see the topic discussed much. Is it common with Lyme and Cos?
Also my anxiety has been going nuts (especially when active). Is this bart, or could it be that my ATP is just whacked? Or maybe both.
Thanks for the help.
Posts: 967 | From A deserted island without internet access | Registered: Sep 2009
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BoxerMom
Frequent Contributor (1K+ posts)
Member # 25251
posted
I think we all have mitochondrial dysfunction. Go to www.endfatigue.com and type it in search.
Dr. T is a big FM/CFS guy. Mitochondrial dysfunction hit the stage as a player in CFS quite a while ago. Before pathogens, in some circles.
There are many supplements targeted to restoring mitochondrial function, but the fact is, herxing makes you tired.
posted
Yes it is a trigger for Mito disease. there are centers in the U.S. now that this is all they do. They are usually called Metabolic and a Mitochondrial Disease Centers. There are some good ones at UC Irvine and UC San Diego in Calif. I will be going to one soon. Most work with newborns/children but some are working with adults.
They run your DNA genome and can see where the cascade is mutated or missing. I asked the genetic counselor what do they do to treat it and she said high CoQ10 300-600mg a day and high Carnitine by a product called Carnitor. I said the alternative doctors have been doing this for years but she said yes but now we have the proof.
She said Lyme or anything can be the trigger and you can be pre-disposed with your genetics.
Posts: 871 | From orange county, ca. | Registered: Jan 2006
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hshbmom
Frequent Contributor (1K+ posts)
Member # 9478
posted
What is their proof?
How do they test for mitochondrial damage?
What is involved in the testing? ...a biopsy, or a blood sample?
Posts: 1672 | From AL/WV/OH | Registered: Jun 2006
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seekhelp
Frequent Contributor (5K+ posts)
Member # 15067
posted
Not sure 'everyone' has it here. I get tired a lot and went through the most extensive work-up from a neuromuscular standpoint possible including deep muscle biopsy. Negative.
Posts: 7545 | From The 5th Dimension - The Twilight Zone | Registered: Mar 2008
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sparkle7
Frequent Contributor (5K+ posts)
Member # 10397
posted
FYI-
Dr. Paul Cheney on Mitochondrial Myopathy, MRS Brain Scans and Chronic Fatigue Syndrome
(I never tried it. Some people have good results with it & some don't.)
Posts: 7772 | From Northeast, again... | Registered: Oct 2006
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troutscout
Frequent Contributor (5K+ posts)
Member # 3121
posted
I would suggest two products that seem to be custom made for this....
ASEA-liquified product of the mitochondria
Max GXL-pre-cursors to what the mitochondria need
Investigate them on your own.
Good Luck,
Trout
-------------------- Now is the time in your life to find the "tiger" within. Let the claws be bared, and Lyme BEWARE!!! www.iowalymedisease.com [/URL] Posts: 5262 | From North East Iowa | Registered: Sep 2002
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Carol in PA
Frequent Contributor (5K+ posts)
Member # 5338
Chronic Fatigue Syndrome - Definition, Test & Treatment - Aug 2005 Dr. Sarah Myhill, www.drmyhill.co.uk LinkPosts: 6947 | From Lancaster, PA | Registered: Feb 2004
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posted
Like Seekhelp, I had every neuromuscular test, including a muscle biopsy, which my neurologist saved for last, as it is fairly invasive (surprisingly so, for the little chunk of muscle that was removed from my thigh!).
Everything was normal except for a slight carnitine deficiency, for which CARNITOR, at a very high dose, and CoQ10 were prescribed. DNA sequencing was done as well...results were normal.
Both the Carnitor and CoQ10 were ineffective, but this all took place before I was diagnosed. My LLMD has me taking both again, I can't tell if it's helping my muscle fatigue and pain.
I don't recommend a muscle biopsy. It's expensive, invasive, and probably won't reveal much, in my very non-medical opinion!
-------------------- IV graduate. As of 1/10, oral Omnicef, Minocyline, Mycobutin, Levaquin, and Flagyl. Lyrica and a bunch of supplements. Posts: 123 | From Atlanta | Registered: Mar 2009
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
- Tests can be painful, expensive and cannot possibly show us an exact blue print of all that goes awry from toxic infections.
This article explains the broad range of actions from borrelia toxins:
BIOCHEMISTRY OF LYME DISEASE: BORRELIA BURGDORFERI SPIROCHETE / CYST
==========================
Not only when to suspect lyme - but how this toxic spirochetal infection (once in the nervous system, in the brain, the heart, the liver, etc.) affects every system, every organ and what that means for a person with lyme:
Mitochrondia matters are discussed in this thread. While some of the links are repeat of those above, there are other links - and video that address this and similar issues relating to endurance, etc. ---------
See the posts for Turmeric/Curcumin and Gotu Kola here. They also help with adrenal support. -
Posts: 48021 | From Tree House | Registered: Jul 2007
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