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» LymeNet Flash » Questions and Discussion » Medical Questions » Over-stimulating Immune System

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Author Topic: Over-stimulating Immune System
canefan17
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How will you know if you are OVER-stimulating your immune system?

I just started taking cordyceps/reishi

These are strong immune booster (DR B even recommends cordyceps)

But how does someone know if they are having auto-immune or over-stimulating effects?


PS: doesn't resveratrol act as an immune modulator?

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sparkle7
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Here's an article about a drug trial that went wrong with a drug that was supposed to stimulate the immune system -

http://www.newscientist.com/article/dn8863-catastrophic-immune-response-may-have-caused-drug-trial-horror.html

excerpt-

A catastrophic over-stimulation of the immune system may have caused the horrific reactions suffered by six men taking part in the first human clinical trial of an experimental drug.

---

Reports from friends and relatives describe the nightmarish symptoms suffered by the men. One man's head was said to have swollen massively and his limbs turned purple. Another was said to resemble the deformed "Elephant Man".

-----------

I'm sure this is extreme but I guess your immune system would start attacking healthy cells.

You have to be careful in boosting your immune system. Sometimes it's better to get a modulator rather than a booster. It's a complex subject.

This article is interesting -

http://www.shen-nong.com/eng/principles/modulationeffectimmune.html

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canefan17
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sparkle,

Do you have a list of good modulators?


I took an immune booster because my WBC was low.

Surely thats a sign of an under-reacting immune system.

*shurugs shoulders*

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sparkle7
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I read other people here who said that Transfer Factor was helpful for low WBC. I never tried it, though. You may want to try a good quality whey...? The Transfer Factor is usually pretty expensive. I'm not sure if either of these will really do it. Just a suggestion. There's mixed opinions about these things.

Also -

http://www.raysahelian.com/autoimmunedisease.html

excerpt-

Q. Are EGCG, the green tea extract, and resveratrol helpful in autoimmune disease?
A. I have not seen such research yet.

----

FYI -

FEEDING YOUR IMMUNE SYSTEM

http://www.askdrsears.com/html/4/t042500.asp

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sparkle7
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This article is good -

Immuno-Stimulation, Immuno-Modulation Or What?

David L. Hoffmann B.Sc. (Hons), M.N.I.M.H.

http://www.healthy.net/scr/article.aspx?Id=1803

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sparkle7
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FYI - just found this (from a post by Keebler)

http://www.mskcc.org/mskcc/html/69227.cfm

Fucoidan has been shown to inhibit metastasis by preventing adhesion of tumor cells to the extracellular matrix. This is achieved by blocking the fibronectin cell-binding domain, necessary for formation of adhesion complexes (4). Fucoidan was also shown to induce apoptosis of human T-cell leukemia virus type I (HTLV-1) that causes Adult T-cell leukemia.

It does so by inactivating NF-kB that regulates antiapoptotic proteins. It suppresses AP-I, a transcription factor involved in cellular proliferation and transformation (3). An vitro study showed that Fucoidan can suppress angiogenesis induced by Sarcoma 180 cells in mice (5).

Fucoidan has immunomodulating effects and enhanced the activity of NK cells, which play a crucial role in mediating tumor cell death (2). The neuroprotective effects of fucoidan are attributed to its ability to suppress tumor necrosis factor-alpha (TNF-alpha)- and interferon-gamma (IFN-gamma)-induced NO production in C6 glioma cells (11) and to its antioxidative effects (12).

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canefan17
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sparkle,

Whats your opinion of whey?

Why do you feel it helps?

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massman
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Stimulate...sedate, stimulate...sedate, stimulate...sedate...

Oh ! WAIT !

This is the US !

Overstimulate...oversedate...overstimulate...
oversedate...overstimulate...oversedate...

WOW ! The new cool word is...modulation !
COOL !

Healing ? Nah, that is old stuff. We can spend much more time playing with over / under / modulate ! Again + again + again ! Cooooool.....

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kday
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Ok, question.

Can an overstimulated immune system cause the neuro/CNS feeling of overstimulation? Just wondering since I suffer from it every day.

massman, while your post is a little crazy for me to follow, I understand what you are saying.

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massman
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I would say it probably could, kday. Everything is ultimately connected in our bodies, so if one part is "hotwired" then that extra electricity will bleed over into another system.

And I do get goofy sometimes as when I talk about healing organs the best they can be healed I about get crucified.

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sutherngrl
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kday, I think it can. I totally had this as one of my main symptoms. Very miserable!

Vitamin D, an immune modulator, has helped my physical lyme symptoms a great deal. But only since getting my D up to around 80 or 90. It does not work as an immune modulator until it gets to the upper range of normal. You can research and find this info. Its very interesting.

Also when I had no choice but to take steroids for 3 weeks, did I start to notice that right after that my antibiotics finally started to work for me. Not condoning steroid use at all! Thats just what happened to me. Could have been a coincidence for all I know. Or it slowed down the part of my immune system that was in overdrive???

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sparkle7
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Whey is supposed to boost glutathione - it's an anti-oxidant.

It's supposed to strengthen your immune system. One famous CFS doctor used to recommend it but he recently changed his mind about it. So, there are conflicting views - as usual.

Some people find it helpful. May want to look into colostrum, as well. I just posted a thread about it.

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lightparfait
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less is more!
work on keeping things simple.
Dr. K recently said...he finds it take 3 months for the body to balance with whatever you are working on. So doing too much at once i counterproductive...stick with a protocol then allow it to take hold and work...then you know if it is successwful.

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sparkle7
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I agree with that lightparfait! I think people way overdo it with these treatments. I don't think the body can handle it - just my experience.
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massman
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In absolute agreement with 2 posts just above [Cool]
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canefan17
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mass,

What are your thoughts on immune modulators (japanese knotweed, resveratrol)?

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sparkle7
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Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810449/

---

They may actually suppress the immune system... I didn't read the whole study. I'll look at it later. It's a complex subject.

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massman
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cane - you already know how I feel about straight herbals vs. specifically mixed herbals [bonk]

Heal those organs so the body can deal with it on its own. [Cool]

[woohoo]

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