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» LymeNet Flash » Questions and Discussion » Medical Questions » Search for protective antigens in Ixodes persulcatus (ixodidae) salivary gland extrac

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Author Topic: Search for protective antigens in Ixodes persulcatus (ixodidae) salivary gland extrac
Pinelady
Frequent Contributor (5K+ posts)
Member # 18524

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News from Russia---http://www.ncbi.nlm.nih.gov/pubmed/20608183 2010 Apr-Jun;
RT-PCR evaluation of the activity of eight Ixodes persulcatus salivary gland genes

shows clear distinctions in their expression depending of
the stage of tick feeding.

... Out of them, only Salp 10 and Salp 15
proteins may be regarded as candidates for protective antigens to
develop anti-tick and anti-Borrelia vaccines.

Firstly they play an
important role in feeding a tick and modifying a host's immune response.

Secondly, the increasing expression of the salp 10 and salp 10 genes
begins at early tick feeding stages.

Thirdly, the activity of these
genes increases with the beginning of feeding by tens and hundreds times
and keeps at this level until the third tick feeding stage is over.
**********************
I hope they are onto the lie that the tick needs to be attached for 24hrs to be infective, and secondly they too finally find they cannot inactivate the stealth genes as others have already exhibited.

--------------------
Suspected Lyme 07 Test neg One band migrating in IgG region
unable to identify.Igenex Jan.09IFA titer 1:40 IND
IgM neg pos
31 +++ 34 IND 39 IND 41 IND 83-93 +
DX:Neuroborreliosis

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