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» LymeNet Flash » Questions and Discussion » Medical Questions » Has anyone heard of using Mepron for seizures?

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Author Topic: Has anyone heard of using Mepron for seizures?
2roads
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Just curious.
Posts: 2214 | From West Chester, PA | Registered: Aug 2003  |  IP: Logged | Report this post to a Moderator
2roads
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Anyone?
Posts: 2214 | From West Chester, PA | Registered: Aug 2003  |  IP: Logged | Report this post to a Moderator
seekhelp
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No way
Posts: 7545 | From The 5th Dimension - The Twilight Zone | Registered: Mar 2008  |  IP: Logged | Report this post to a Moderator
gatorade girl
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It is an anti malaria drug used for babesia

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gatorade girl

"I still have Mt.Everest to climb, but I have traveled across the world and arrived at the mountain".

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2roads
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Yea, that's what I thought.

But that was the question posed to me by a technician in the pharmacy.

Posts: 2214 | From West Chester, PA | Registered: Aug 2003  |  IP: Logged | Report this post to a Moderator
Keebler
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As seizures can be from infection, I can see that if a person had seizures as a result of babesia, mepron could very well reduce severity and frequency of seizures.

However, according to the last link below, some seizures can get worse with mepron. I think that is likely a herx reaction in case of infection, and a porphyria reaction in cases of liver dysfunction. Or just too much or not the right medicine for others.

Unless there is an infection that requires mepron, I think it should be avoided as it can be very hard on the liver. If infection requires it, liver support is important but is a bit tricky to maintain the therapeutic dose of the Rx.

Magnesium is still the number one support supplement, though, along with anti-infective medicine. Magnesium supplementation, alone, can reduce seizures as seizures are often a symptom of magnesium depletion.

=======================

http://www.vrp.com/articles.aspx?ProdID=art1066&zTYPE=2

Seizures: A Nutritional Approach

Seizures can be attributed to a number of causes including metabolic abnormalities, infections, nutritional deficiencies, or trauma. . . .

========================

One result from a Google search of: mepron, seizures
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www.flexyx.com/M/Mepron.html

MEPRON

Excerpts:

A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation.

Mepron has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated).

It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603)

Mepron is a controlled substance in the U.S. . . .

. . .

Mepron Contraindications

Acute intermittent porphyria* as well as allergic or idiosyncratic reactions to meprobamate or related compounds such as carisoprodol, mebutamate, tybamate or carbromal. . . .

======================

* (from reference of contraindication)

http://flash.lymenet.org/scripts/ultimatebb.cgi/topic/1/91842?

PORPHYRIA Thread
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Posts: 48021 | From Tree House | Registered: Jul 2007  |  IP: Logged | Report this post to a Moderator
2roads
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That's what she asked. Therapy against petit mal not grand mal seizures.

Either way, it was inappropriate.

Thanks Keebler

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Keebler
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I'm not sure what you mean by, either way, it was inappropriate. So, she does not have babesia and she is having grand mal seizures? [But, keeping in mind that the grand mal consideration in that one link could have been a herx and was misinterpreted.]

If she was prescribed mepron for seizures, the doctor likely has reasons.

A much more intensive search would need to be done to determine that - and if a doctor prescribed this there may be some very specific reasons. She should discuss her questions with the doctor.

A minute on Google just touches the surface. I did not do a complete search of this, but just from ONE source - just a crack of the door. ALL sources need to be studied, which, I assume would be done by the patient.

She needs to be talking with her doctor about this for better understanding. The pharmacist, too, may have some details for her. PubMed may have more details. I'd contact the Epilepsy organizations, too, and look through archives there if they have any sort of library link.

But nothing on the web will be enough to make any kind of armchair decision. We do not have all the details or the training.

There is no way we can say that was or was not a good idea. It's just more complex than that.

You seem to have said she does not have babesia. Also keep in mind that she may have another kind of infection that mepron may address, besides babesia and malaria (& chronic malaria).

Her doctor may have integral information - or had other patients for whom this worked. There are many variables to consider. Open communication with the doctor is the place for her to begin.

If one has to be on a seizure drug - and if they have a chronic infection - it's better to be on a seizure med that also had anti-infective properties than on one that just depressed the nervous system as most do.

So, if this woman MIGHT have a parasitic infection that could be the cause of her seizures, this may turn out to be just what she needed. I hope she has good self-care and supplement instructions along with this to minimize possible herx that could be misinterpreted.
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[ 08-08-2010, 03:43 PM: Message edited by: Keebler ]

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2roads
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No Keebler,

The Pharmacy Technician asked me if my son had that and/or what we were treating.

It was none of her business. That's all I meant.

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Keebler
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Oh. She may have spoken out of turn . . . or she may have been trying to save your son's life by following safety precautions for medical conditions that have contraindications with other drugs.

If mepron had been dispensed for seizures, the pharmacy tech might have wanted to give additional instructions.

Also, if it had been for seizures, she would have noted that your son's file to red flag any future prescription requests that might not be safe for those with seizures or would adversely interact with mepron in a way that would not be good for a seizure patient.

Most pharmacies have such a red-flag system.
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2roads
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Yea, maybe, but they should've called the doctor with any questions. I've been having trouble with the Mepron consistency when they pour it into other bottles. This wasn't the first time the medicine had been filled.

This may have been an irritant and sparked these questions that violated my rights. But, I was not aware that Mepron was used for seizures. I'm sure it was a conversation piece leading into asking why we were on treatment anyway.

I am grateful for their help thus far, but they have done me wrong on occasion with the Mepron ordeal. Instead of working with me, I get this.

Posts: 2214 | From West Chester, PA | Registered: Aug 2003  |  IP: Logged | Report this post to a Moderator
   

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