Vincent, Alan, and Rich speak with Ila Singh about the new human retrovirus XMRV, and how her laboratory is studying its association with prostate cancer and chronic fatigue syndrome.
Present in prostate cancers but may not be causing it. It is evident that it is not a genetic marker, as anyone can get it...
States need sensitive testing to detect. Virus is opportunistic.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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She stated that they have found 9 in the 100 group study and expected 9 more...
They were going to do many assays/tests to try to find associated pathogens.
To me it obvious. And they will be looking for all those things that are known to be very hard to find---and those that are known to depress the immune system.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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Thanks for the post. However, I don't believe Dr. Singh said XMRV is opportunistic. In fact, I don't believe any human retrovirus, exogenous or endogenous, has ever been characterized as "opportunistic." Can you point me to where she said or implied that?
thanks, joey
Posts: 713 | From Los Angeles | Registered: Oct 2007
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Pinelady
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She said it may be that all of us are susceptible!
The interviewer stated it looked opportunistic. I don't know where they got their info but I guess they don't do WIKI http://en.wikipedia.org/wiki/XMRV A German study found XMRV in 2%-3% of healthy controls and 10% of immunocompromised patients.[12] And it was not refuted/ it is too early to know who all is infected....
This is hard to detect and found mostly in very small quantities. Needs very sensitive, specific tests.
And needs to be able to sort the micro-tomes of mouse virus. Using very rigorous lab standards.
XMRV is present in prostate cancer but cannot say XMRV causes it.
Could be a sensitivity issue of the testing.
Looked in weaken immune systems yet? XMRV is being looked at in autopsy studies. Looking at other infections, transplants, etc. etc. Too early to say....Multiple tissues as well as prostate. Looking at both male and females.
Does not know where it came from. Presence in healthy people could be multiple explanations.
Immuno histochemistry is better to test for it than RNA/DNA.
Tested over 200CFS patients----found many categories to put them in.
Looking at every faction of blood. Prostate is obvious, in CFS it could be anything.
Judy Mickovits gave names samples who are pos. and coded and collected directly to lab.
9 samples so far, expect 9 more out of the 100 to be researched.
Meeting at NIH in Sept. on XMRV
Shown to be susceptible in lab to HIV drugs, and a couple of drugs like AZT/TDF in cell culture only.
Some people already using them. Without clinical trials..
How common is CFS in US? .5-2%
XMRV CFS link should patients give blood? Several countries has asked them not to donate.
States disease state could be associated with detection. Could vary widely... They don't know if it leads to more aggressive cancers.
Talked of the HPV/HIV associations to cancers took a long time to conclude.
Science is self correcting eventually.
Vaccine associated? No evidence
Can clusters be explained? Some infectious agent is possible. 1/4 from the 80's in NV.
What tissues does it prefer in women? Don't know yet. It may respond to other hormones at different levels. Not done yet.
They don't know if they are causing the illness or if it is just associated.
XMRV is a gammaretrovirus. They insert their own genetic material which allows growth.
The presence in tumors is not in large amounts so cannot solidify causation.
What if the main reservoir is the brain or the nervous system...It could be a big problem
Stem cell treatments---interviewers thought horrible idea...She said she don't know.
Looking at cervical tumors. 300 fluid samples trying to detect it. Don't know if it is there.
Are there co-factors in development of cervical carcinoma. HTLV 1 causes T cell lymphoma in only 5 percent and don't know why...Could be co-factors.
Given the future would antiretrovirals help in treatment? Don't Know.
Co infection is possible as causative factor. Still a lot to learn. --------------------------- I believe the idea is --that it is opportunistic because so far some have found it in HIV/HEP/and other chronic infections like Lyme.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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This mini-review summarizes current knowledge of MSRV (multiple sclerosis-associated retrovirus), founder ...member of the type W family of human endogenous retroviruses (HERVs)
its pathogenic potential and association with diseases. As retrotransposable elements, HERVs behave differently from stable genes, and cannot be studied with "Mendelian genetics" concepts only.
They also display complex interactions with other HERV families, and with classical viruses.
These concepts may contribute to unravelling the etiopathogenesis of complex diseases such as
multiple sclerosis, schizophrenia, and other chronic multifactorial diseases.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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Makes me wonder if it is the bacteria carrying the virus as in Hanta virus that can infect mice but not effect. Which is why they are seeing such small amounts even in those very infected...
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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http://www.ncbi.nlm.nih.gov/pubmed/20668521 The flaviviruses causing tick-borne encephalitis (TBE) persist at low but consistent levels in tick populations, despite short infectious periods in their mammalian hosts and transmission periods constrained by distinctly seasonal tick life cycles.
Therefore, the common assumption that cofeeding transmission is not relevant in models of chronic host infection, such as Lyme disease, could lead to underestimating pathogen prevalence.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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Pinelady
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This I did not know but I won't be happy until they look at our borrelia for it.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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