RZR
Frequent Contributor (1K+ posts)
Member # 20953
posted
Doctors keep prescribing PPI for my stomach problems. Right now, I think the yeast is a big issue with my problems.
Would it be more beneficial to add a PPI or HCL and digestive enzymes? After researching, I found problems are usually due to not enough stomach acid instead of too much.
Is the purpose of a PPI to decrease stomach acid long enough for the stomach to heal?
-------------------- Tick bite May 2009 Diagnosed June 2009 Posts: 2329 | From SouthEast | Registered: Jun 2009
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
To clear Bb from the GI track only, they gave Tritec which is a H2 BLOCKER (histamine)combined with Bismuth citrate.
It is now only avail. in Europe though theoretically it could be compounded here.
From some respects, it was the bismuth (as it degrades) that destroyed ALL FORMS of Bb in the GI track.
No...not Pepto Bismol...wrong form.
And no...can't work "everywhere" and can -> death if tried IV.
However...the H2 blockers REDUCE our stomach acids which is HCL. The one in Tritec is called rantinidine = "Zantac".
Bb does indeed trigger the chloride channels and looks to exchange H for Na because...
Bb needs NaCl for motility.
Only the H1 blockers cross the BBB = blood brain barrier.
Things like Benadryl and the chemical in Unisom SleepTABS are H1 blockers.
To benefit from the H1 effect while preventing the "sleepiness" of them =
Sublingual B6. B6 is destroyed by stomach acids if not taken sublingually or if not in a "coated" tablet.
A deficiency of B6 makes us sleepy.
B6 has THE most functions of any vitamin.
Many years ago pregnant women took a drug to prevent the nausea and vomiting of pregnancy called Bendectin. It was erroneously pulled from the market when a doc said it could cause birth defects. He falsified the research and lost his license, but the "damage" was done as it was removed permanently from our market.
This combination of an H1 blocker and B6 is still sold in other countries under a different name and is a first line choice to stop hyperemesis.
When Bendectin was pulled off the market, the # of premature babies DOUBLED.
Too much histamine is harmful to a fetus. In fact, pregnant women make an enzyme to lower histamine called DAO. That enzyme goes up 500 fold.
I suspect there are some women who genetically have higher levels of histamine and this puts them at greater risk for premature L+D.
So what do they give when premature L+D happens?
IV Mg!
Anti-histamine, anti-inflammatory and inhibits HMG CoA reductase (like a statin drug).
What they give pregnant women with hyperememsis now is $$$ Zofran which works from a serotonin angle which does help out.
Tryptophan (-> serotonin) METABOLITES (breakdown products)inhibit the normal degradation of histamine.
So if one can keep the level of serotonin higher longer, this helps prevent the metabolites from impacting histamine.
We make the neurotransmitters all the time really really fast. They help to send a message forward and then they are broken down, so this is what happens:
neurotransmitter made -> message sent -> neurotransmitter broken down -> neurotransmitter made...
Very very very fast.
To the best of my ability.
BTW...we NEED HCL to help us digest our foods so we can utilize the nutrients in the food to make our proteins, enzymes, neurotransmitters, etc.
So do not take a H2 blocker too close to a meal.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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Dawn in VA
Frequent Contributor (1K+ posts)
Member # 9693
posted
@Marnie- if you have a moment, could you PM with what the correct form of bismuth is? I have a pretty good compounding pharm. here and would be interested as to what they thought/would do. I have a G.I. appt on the 20th.
@Jennie- I had/have similar tummy issues and questions and read the same thing you did re: low vs high stomach acid.
If you're thinking yeast, have you given diflucan (at least a few days worth IMO) a shot?
YES YES YES to digestive enzymes; make sure you get a brand that contains many different enzymes, not just one or two. And a gluten-free diet may help as well if you're not on one already.
I had a colonoscopy and endoscopy done last Oct. In a very recent conversation with my LLMD: "If they took biopsies from more than one or two areas of your colon and you sent them to a lab that tests for Bb, they'd surely show up there."
Regarding B6 -yes it's good stuff- but just a reminder that you can overdo it, so pay attention to labels on your multivitamins, B-complex, sublinguals, etc. to make sure you're not overdoing it. (No, sorry, I don't know what dosage would constitute as "overdoing it".)
-------------------- (The ole disclaimer: I'm not a doctor.) Posts: 1349 | From VA | Registered: Jul 2006
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posted
Marnie, there is a combination of things you can take that is the same as that old drug, or similar .... my ob/gyn had me take it with one of my pregnancies .... I think it was half a Sominex (???) and B6. It helped, but I was just tired all the time. Seems like Benadryl would work, too, instead of the Sominex. That was 17 years ago, so don't take this combo in case I got it wrong!
-------------------- sixgoofykids.blogspot.com Posts: 13449 | From Ohio | Registered: Feb 2007
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