posted
I am sending this information about two "big news" from our UNH Lyme Disease Research Group.
1. The first one is that our "big paper" got published this week and it had already received a lot of very positive feedbacks. The main message from the paper is that antibiotics do not kill all forms of Borrelia, the Lyme Disease bacteria. The previous studies only looked at one form and when we looked at all 3 different forms of this bacterium we have found that main antibiotics used in Lyme disease are capable eliminating all the forms. Here is the paper http://www.dovepress.com/articles.php?article_id=7341
2. The second big announcement is that we have our UNH conference on May 21st 2011. It will be a half day program dedicated to present the latest findings of our research group. We have 2 guests: two very famous Lyme Disease Physicians: Drs. Charles R Jones and Joseph Burrascano
The program free to the public and of course we would like to see you!!! bests Eva
Here is the program announcement:
SAVE THE DATE "Breakthroughs in Lyme Disease Research" Join us to hear our news --- the latest findings of the Lyme Disease Research Group at the University of New Haven
Saturday May 21, 1PM ~ 8PM University of New Haven ~ Dodds Theatre 300 Boston Post Road, West Haven, CT 06516 ~ Free and Open to the Public ~
Speakers to include: Dr Charles Ray Jones- Keynote speaker Dr Joseph Burrascano - "Recent Research Breakthroughs in Lyme Disease" Dr Eva Sapi - "Evaluation of in vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi" Graduate Thesis Research Projects: David Luecke - "Unraveling Unique Features of Borrelia burgdorferi Biofilm" Amy Rattelle - "Evaluation of Matrix Requirement for Borrelia burgdorferi Biofilm Form" Yram Foli - "Antimicrobial Effects of Medicinal Aromatic Oils on the Different Morphological Forms of Borrelia burgdorferi" Namrata Pabbati MS - "Novel filarial Nematode Infection in Ixodes Scapularis ticks Collected in Southern Connecticut"
A panel discussion and networking reception will follow the presentations.
Lymeorsomething
Frequent Contributor (1K+ posts)
Member # 16359
posted
Thanks Al. I hope I can make it to that conference.
It looks like something as simple as Amoxy and Flagyl may be a viable combo. The trick would then be to hit the biofilms too. Combining certain abx with natural protocols, like Cowden, grapefruit seed extract, etc. may be the best bet...
-------------------- "Whatever can go wrong will go wrong." Posts: 2062 | From CT | Registered: Jul 2008
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posted
Gee, this sounds interesting. Would love to hear this knowledge firsthand, also to learn about Medicinal Aromatic Oils.
Anything that could help treat Lyme and possibly help the Morgellon's that is relentless in making my life a lot like *ell.
Posts: 245 | From Texas | Registered: Jul 2009
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METALLlC BLUE
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Member # 6628
posted
For those interested in reading it directly here: my paper "The Case For Chronic Infection" chronicles these reports, and you'll find the study at the very bottom.
posted
Eva Sapi1 University of New Haven, New Haven, CT, USA; International Lyme and Associated Diseases Society, Bethesda, MD, USA
Background: Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi. Although antibiotic therapy is usually effective early in the disease, relapse may occur when administration of antibiotics is discontinued. Studies have suggested that resistance and recurrence of Lyme disease might be due to formation of different morphological forms of B. burgdorferi, namely round bodies (cysts) and biofilm-like colonies. Better understanding of the effect of antibiotics on all morphological forms of B. burgdorferi is therefore crucial to provide effective therapy for Lyme disease. Methods: Three morphological forms of B. burgdorferi (spirochetes, round bodies, and biofilm-like colonies) were generated using novel culture methods. Minimum inhibitory concentration and minimum bactericidal concentration of five antimicrobial agents (doxycycline, amoxicillin, tigecycline, metronidazole, and tinidazole) against spirochetal forms of B. burgdorferi were evaluated using the standard published microdilution technique. The susceptibility of spirochetal and round body forms to the antibiotics was then tested using fluorescent microscopy (BacLight� viability staining) and dark field microscopy (direct cell counting), and these results were compared with the microdilution technique. Qualitative and quantitative effects of the antibiotics against biofilm-like colonies were assessed using fluorescent microscopy and dark field microscopy, respectively. Results: Doxycycline reduced spirochetal structures ~90% but increased the number of round body forms about twofold. Amoxicillin reduced spirochetal forms by ~85%�90% and round body forms by ~68%, while treatment with metronidazole led to reduction of spirochetal structures by ~90% and round body forms by ~80%. Tigecycline and tinidazole treatment reduced both spirochetal and round body forms by ~80%�90%. When quantitative effects on biofilm-like colonies were evaluated, the five antibiotics reduced formation of these colonies by only 30%�55%. In terms of qualitative effects, only tinidazole reduced viable organisms by ~90%. Following treatment with the other antibiotics, viable organisms were detected in 70%�85% of the biofilm-like colonies. Conclusion: Antibiotics have varying effects on the different morphological forms of B. burgdorferi. Persistence of viable organisms in round body forms and biofilm-like colonies may explain treatment failure and persistent symptoms following antibiotic therapy of Lyme disease.
Posts: 789 | From CT, | Registered: Jun 2006
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Tracy9
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Member # 7521
posted
It looks to me like Tigecycline and Tindamax are the best combination?
13 years Lyme & Co.; Small Fiber Neuropathy; Myasthenia Gravis, Adrenal Insufficiency. On chemo for 2 1/2 years as experimental treatment for MG. Posts: 4480 | From Northeastern Connecticut | Registered: Jun 2005
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This makes perfect sense to me. I was on Doryx only for 5 months, had great symptom reduction. Then, was on nothing for several months, and my symptoms returned with a vengeance. Next, I tried Ceftin alone (no improvement), Zithromax (no improvement) and then started Flagyl, instant reduction in symptoms to nearly gone. So, the doryx allowed the spirochetes to turn to cyst form, and I was not on a cyst buster. Then, the flagyl killed the spirochete and cyst forms. Now, I need to learn more about how to kill the biofilm forms. Interesting!
Posts: 143 | From Louisville KY | Registered: May 2010
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RDaywillcome
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posted
up
Posts: 1738 | From over the rainbow | Registered: Jul 2009
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beths
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posted
I think it's either Tigecycline or Tindamax -I don't think they mean togethr, but I could be wrong.
Posts: 1276 | From maryland | Registered: Jan 2009
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lpkayak
Honored Contributor (10K+ posts)
Member # 5230
posted
"when we looked at all 3 different forms of this bacterium we have found that main antibiotics used in Lyme disease are capable eliminating all the forms"
ok-i read the study and the summary and i still don't see what combo gets 100% of Bb
i know i'm cognitively messed up...but this is really impt
could a doc or scientist or someone from UNH please make a simple statement:
to get rid of lyme disease take the following abx at what dose for how long?
-------------------- Lyme? Its complicated. Educate yourself. Posts: 13712 | From new england | Registered: Feb 2004
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posted
Yeah, been thinking about that for a week:)
"to get rid of lyme disease take the following abx at what dose for how long?"
Posts: 31 | From NY | Registered: Jul 2005
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t9im
Frequent Contributor (1K+ posts)
Member # 25489
posted
Hi Lpkayak:
I went to the conference at UNH with Dr. S and her presentation with the comparisons of drugs with spirochete and cyst load.
Tindamax and Doxy was the best combination. Tindamax was the best stand alone.
Unfortunatley for the time lenght used there was not 100% eliminaton of the spirochete or cyst. This is all in the test tube, in vitro, not in a host body, in vivo.
-------------------- Tim Posts: 1111 | From Glastonbury, CT | Registered: Apr 2010
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James1979
Unregistered
posted
Is there a video anywhere of the conference?
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