Topic: Mepron + HLA DR bad Detox Gene = Nervous System going Bonkers. How do you do this ?
lymetwister
Frequent Contributor (1K+ posts)
Member # 19590
posted
Ok, need the troops once again... This is my 2nd time taking Mepron + Artemisinin. The first time, it was added to Lyme meds and I was doing IV. It was too much so decided to address it later. Well, now is later.
I made it 13 days straight and then the Herxing was too much, so I backed off for 3 days and restarted. Made it 6 more days, then off again now x 24 hours.
Here is what is happening:
I am waking up each and every morning Shaking both internally and externally, I'm short of breath as soon as I get up and just sit on the side of the bed. It' not a true "Air Hunger", but just alot of dysregulated breathing with alot of breath holding and when I try and slow it down, my cheeks puff out.
I know it might sound crazy, but I'm so tired that I go for some coffee b/c I feel so out of it. My head is doing weird stuff, wooshy sensation. Nightmares are now every night, mostly in the morning hours. I wake up and it's like I'm still in the dreams for a short while.
So, I get my office and just sit here and take my a.m. Klonopin, a small piece of Xanax, and whatever else I need until it calms down. All the while, I'm busting out into tears in total despair. It's like my Nervous System is going wild and I can't get it under control.
I know what General Anxiety Disorder and Panic Disorder are and this is Neither ! I know it is Mepron induced or lets say the Mepron makes this baseline symptom 100x worse.
LLMD says I'm killing the BABS. Recent lab shows PCR + for BAbs Duncani, so it would appear the Lab confirmation and symptoms are what I'm dealing with. Way back when, I was told I was loaded with Babs. So the 2-3 day half life is what I'm up against in addition to Detoxing better.
My Shortness of breath comes and goes throughout the day, but the Nervous crap is nothing like it is first thing in the morning.
I hate this b/c I have to be in a holding pattern now and I always feel like I'm not killing anything and perhaps Herxing for nothing.
I would trade the CNS problems for anything else. This one has been by far the hardest thing to deal with since the beginning of all of this just a bit over 4 years ago now.
Appreciate your thoughts...
Gary
Posts: 1227 | From District of Columbia | Registered: Mar 2009
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posted
Have you ever had a sleep study done? Hubby used to put his CPAP on in the daytime to calm him down -- it will force your breathing to slow down.
He quit using the CPAP even at night 2 or 3 years ago after he started treating bart -- just felt like he didn't need it any more.
2nd suggestion -- are you taking the klonipin and xanax on a schedule? Do you take any overnight? Depending on your metabolism you could be going thru drug withdrawal every day. For a few years I set the alarm clock and woke hubby in the middle of the night to give him oral ativan and oral phenergan. Now he is on a schedule where he wakes up by himself and takes his meds at midnight and 6:00 a.m. on his own.
Bea Seibert
Posts: 7306 | From Martinsville,VA,USA | Registered: Oct 2004
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Maybe try Malarone instead of Mepron, some llmd's think it's better for Duncani than Mepron.
Posts: 269 | From VA | Registered: Jun 2005
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lymetwister
Frequent Contributor (1K+ posts)
Member # 19590
posted
Feels like I'm hitting it, just too hard.. Backing off and Detoxing hard so I can prepare for the next round.
Crazy stuff.. I'm sure the HLA DR genotype is a big player here.
Sux
Posts: 1227 | From District of Columbia | Registered: Mar 2009
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