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» LymeNet Flash » Questions and Discussion » Medical Questions » MTHFR C677T & A1298C Present

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Author Topic: MTHFR C677T & A1298C Present
momintexas
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Does anyone else have this and can you explain to me what it means?

I've googled it, but I'm having a hard time understanding.

Thanks!

Posts: 1408 | From Tx | Registered: Nov 2009  |  IP: Logged | Report this post to a Moderator
Tincup
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Try this...

Go to www.MarylandLyme.org Look on left side menu and click on MTHFR.

More info on subpages at bottom of main page. Hope that helps!

--------------------
www.TreatTheBite.com
www.DrJonesKids.org
www.MarylandLyme.org
www.LymeDoc.org

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BuffyFan
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just a quick question, if a person has a normal homocysteine level, is there no chance of a MTHFR mutation?
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txgirl09
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Buffy --- no lots of people have normal homocysteine (me) and have 2 mthfr mutations.
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BuffyFan
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should I request this test then? I don't know if my dr will think it's necessary??? can't afford an llmd right now. don't know if I can afford to do this test if I have to pay for it. I also have a neighbor who's grandson has autism. I"m going to print out this info and give it to her.
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momintexas
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Thanks a lot Tincup.

That link helps a lot.

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nefferdun
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It is pretty serious to have one copy of each. Here are some sites that may help you;

This a great site for understanding the effects of the mutation and how to treat it. He will answer questions:
http://mthfr.net/read-this-first/2012/01/25/

This discusses treatment of CFS caused by the mutations with the Amy Yasko protocol
http://health.groups.yahoo.com/group/CFS_Yasko/

For the grandchild with autism:
http://www.ch3nutrigenomics.com/phpBB2/viewforum.php?f=29&start=0

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old joke: idiopathic means the patient is pathological and the the doctor is an idiot

Posts: 4676 | From western Montana | Registered: Apr 2009  |  IP: Logged | Report this post to a Moderator
nefferdun
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I have been doing some research this morning. The C677T mutation, which I have one copy of, is connected to stroke and heart attack because it can cause blood clotting. A resent test I took shows I have high thrombin antithrombin complex, which means hypercoagulation.

One doctor I found online said 90% of lyme disease patients have hypercoagulation as compared to 5% in the normal population.
We should take Heparin which thins the blood and is also anti-inflammatory and kills bacteria.

With the blood thinner we should be able to remove toxins better, assimilate medications better and it also improves fatigue and brain fog.

momintexas, I hope you can find everything you are looking for to help get your body working correctly. It should be a very dramatic change in the way you feel. It is very important that you have your children tested as well and tell any other blood relatives.

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old joke: idiopathic means the patient is pathological and the the doctor is an idiot

Posts: 4676 | From western Montana | Registered: Apr 2009  |  IP: Logged | Report this post to a Moderator
nefferdun
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This is a nearly brain dead attempt at an explanation. You cannot property assimilate B12, Folate and B6. In fact, with two copies, your ability to assimilate these vitamins is reduced over 90%.

Your body cannot break those vitamins down in the form they come in from food and most supplements. You need to take them in a form that is already broken down for you so your body can use them. This is the methylated form.

Your body will then use them along with methionine and alpha lipoic acid etc to make glutathione, the most powerful antioxidant in your body. If you do not have enough glutathione, when you get sick, you stay sick. You have a lot of inflammation and you cannot detox well.


If you cannot detox, inflammation increases. You have the herxes from hell. You have serious side effect to medications. You have a lot of pain and brain fog and serious fatigue. You cannot get rid of environmental toxins like heavy metals and cancerous substances. You immune system is compromised. You can't fight off infections.

The C677T mutation causes clotting. This is why many women with this mutation have miscarriages. Clots form in the tiny capillaries supporting the baby. Women with this mutation have a lot of clots with their periods. You also need to take heparin to thin the blood.

Untreated, all of this can cause many problems including stroke, heart attack, depression, addiction, (or) intolerance to alcohol/drugs, dementia, chronic illness, auto immune disease, cancer, chronic fatigue, ADD/ADHD, mental disorders etc. The C577t is related to Down's Syndrome. 98% of kids with Autism have this mutation.

Thank God you found it!

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old joke: idiopathic means the patient is pathological and the the doctor is an idiot

Posts: 4676 | From western Montana | Registered: Apr 2009  |  IP: Logged | Report this post to a Moderator
ladyjenie
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I have Factor V leiden, is this the same as C677T? The hematologist I see told me to take low-dose aspirin daily since I had only one of the genes.

Is there other gene testing necessary to test for either two mentioned?

I am confused and don't understand who does all this testing. My LLMD never mentioned any of these tests but knew I had Factor V.

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sk8ter
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go to MTHFR.net and join it
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Tincup
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Glad it could help!

Hey neffer...

Might I put your wonderful explanation on the website? I can not do 1/10 of the job you just did explaining it.

What you wrote was perfect and should help others!

Please let me know.

Thanks!

[Big Grin]

--------------------
www.TreatTheBite.com
www.DrJonesKids.org
www.MarylandLyme.org
www.LymeDoc.org

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momintexas
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Nefferdun, thanks so much for posting all of that!

Unfortunately....it's my mom that has this. Very, very worried about her. [Frown]

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momintexas
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Can anyone tell me what kind of Dr we need to see for this?
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Tincup
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It is recommended on the test results you are given to see a geneticist. Other than that, any doc knowledgeable might be of help? Or not?

--------------------
www.TreatTheBite.com
www.DrJonesKids.org
www.MarylandLyme.org
www.LymeDoc.org

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sparkle7
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Nattokinase & lumborkinase can help with sticky blood. Enzymes like serrapeptase help too.

fyi - http://www.taoofherbs.com/articles/88/NeprinolEnzyme.htm

Ginko biloba is suggested, as well -
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716226/

Ultimately, the liver & kidneys have to be functioning properly to filter the blood - so, this is where proper methylation helps. You don't always need to take a drug.

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nefferdun
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Gosh, I am shock I made any sense. I try so hard to make sense of it to myself. Sure you can use it Tincup.

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old joke: idiopathic means the patient is pathological and the the doctor is an idiot

Posts: 4676 | From western Montana | Registered: Apr 2009  |  IP: Logged | Report this post to a Moderator
Tammy N.
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Good explanation, Neff.

How are you feeling on your supps?

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nefferdun
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momintexas, getting treatment will greatly help your mother. I think a ND that understand this might be the way to go. Try doing a search on Ben Linch or Amy Yasko. Yasko is very knowledgeable about treating children with autism. There is a yahoo site that might help. Here it is:

http://health.groups.yahoo.com/group/CFS_Yasko/

You probably know that everyone else in the family should be tested as well. Don't wait for symptoms.

Tammy, I am doing pretty well on the vitamins. I started doxy last week because I was having aching in my lower legs. My energy seems to be increasing. i can sleep better and I generally feel pretty good.

I am finding out more and more things.

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old joke: idiopathic means the patient is pathological and the the doctor is an idiot

Posts: 4676 | From western Montana | Registered: Apr 2009  |  IP: Logged | Report this post to a Moderator
momintexas
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Thanks for all your help nefferdun.

I've been tested and have one copy. I need to get the rest of the family to go too.

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BuffyFan
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was testing covered by your insurance? I know we all different insurance companies/plans but was just curious or did you pay out of pocket>?
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