I have been thought to be sensitive to sulfa drugs
if not allergic (dad is allergic) I get red faced
when I take them but generally not anything more,
however, I don't understand why I can't do
glutithione? Also NAC - is that also sufa
related -- any help on this would be greatly
appreciated.
I know I have trouble detoxing, but are there
certain people that should not do glutithione etc.
Thank you-
Posts: 859 | From Southeast | Registered: Mar 2011
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chiquita incognita
Unregistered
posted
Hello Friend I cannot answer your question about the headache and don't know. And I can't diagnose anybody, I never do that. It would be important to tell your doctor about this, they can't know how to work with you/us unless we as patients tell them how we respond as they treat us.
NAC---does boost glutathione in the liver and is a form of sulfur,which detoxifies. I would think that it would be much more mild when taken orally than when something is administered by IV, so I would suggest (ask your doctor first, of course) that after this headache/lousy feeling from the IV clears up, you could try a low dose orally and see how you tolerate it. Then creep up the dosage very gradually. Be sure to report any unusual symptoms to your doctor.
NAC Is not a sulfa drug, it' s an amino acid nutrient supplement. So you can stop it at any time.
You mentioned difficulties with detoxing? Have you read up about Leaky Gut Syndrome? If not I would suggest you read Elizabeth Lipski, CCN MS's excellent bookLET about this, it's about $6 on Amazon's site and explains the symptoms, physiology and remedy very well. It will enable you to ask more health-supporting questions of your doctor after reading it. Note that it's an alternative medicine diagnosis and a mainstream doc may or may not be familiar with it, depending on how integrative s/he is in his/her practice. But the booklet could shed a lot of light for you, regardless.
This is not a diagnosis, it is only a lead/possibility, to be checked out further with your doctor or a naturopath. If this interests you, you can find a naturopath here: www.naturopathic.org
I also recommend the book Natural Therapy for your Liver, it's on Amazon's site and is excellent.
Is it possible you got too much glutathione and the situation arose from some sort of imbalance? Maybe it's not that you can't tolerate it, but that it was too much, *for you*? You would have to ask your doctor about that question. Again I don't know.
Dogsandcats
Frequent Contributor (1K+ posts)
Member # 28544
posted
I did not have headaches, but the sulfur taste was a bit gross. I also seemed to have a bit of indigestion after. I first used it thru a nebulizer, which was ok, other than the sulfur smell and taste were stronger. I am a bit of a wuss with smells. Don't know if this helps, just throwing my experience in.
-------------------- God will prepare everything for our perfect happiness in heaven, and if it takes my dog being there, I believe he'll be there.
Billy Graham Posts: 1967 | From California | Registered: Oct 2010
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Sammi
Frequent Contributor (1K+ posts)
Member # 110
posted
I have a sulfur allergy but my doctor wanted me to get a glutathione push. I was given an antihistamine first.
Initially the glutathione seemed to help me, but over the next several days I experienced horrific and intense itching. This went on for some time.
My doctor thinks my reaction was likely related to detoxing and not an allergy. I don't know which it was, but I will never do it again.
Posts: 4681 | Registered: Oct 2000
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Razzle
Frequent Contributor (1K+ posts)
Member # 30398
posted
If a person has genetic variants that affect methylation, then glutathione and NAC may indeed cause them to feel very sick.
One must compensate for the genetic variants before glutathione (or precursors) can be safely ingested or given by IV.
-------------------- -Razzle Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs. Posts: 4166 | From WA | Registered: Feb 2011
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merrygirl
Frequent Contributor (1K+ posts)
Member # 12041
posted
headache is a very common side effect from Glutathione infusions. You could try less glutathione and infuse it much slower. work your way up to the full dose. Your doc should know this. very common.
Posts: 3905 | From USA | Registered: May 2007
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posted
Hi Everyone: This is very helpful information. I know that at one point I did bloodwork and it said that I have trouble detoxing. I am wondering if this is at all related. I to read this information Razzle and I can't get my head around it. Of course I am on rifampin right now and don't feel all here... other than better now that I am taking it on an empty stomach- thankfully I paid attention finally to that piece of info. I think sometimes we are so sick we miss a lot.
CI, due to absorption issues,they are relatively assured I have leaky gut. I can't ever seem to get enough protein or calcium. Have MANY food allergies/sensitivities. I will check out that book.
Razzle - is there any way to tell if you have these methalation problems? I don't want to take things that make me feel worse.
Thanks for all of your help!
Posts: 859 | From Southeast | Registered: Mar 2011
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GiGi
Frequent Contributor (5K+ posts)
Member # 259
posted
Please search here for some of my posts on NAC, etc.
And then read the Allergie Immun Germany thread.
Take care.
Posts: 9834 | From Washington State | Registered: Oct 2000
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Razzle
Frequent Contributor (1K+ posts)
Member # 30398
posted
Yes there is a test that can be done to detect genetic variants that affect methylation (and detoxification). It is expensive...but the price has actually dropped since I had the testing done.
Dr. Yasko's website is the best price for the test (I have no financial connection with Dr. Yasko, her company/lab, or anything sold on her website):
Methylation is very complicated - I've been reading about it and trying to learn more about it for a few years, and still get totally confused and lost sometimes. But I've finally managed to get the basics down to a certain extent... Dr. Yasko does give quite a bit of information with the test kit that is really good to go through and try to at least get some familiarity with the material. She also sends out a lot of stuff with the test results that is helpful.
I hope this helps...take care,
-------------------- -Razzle Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs. Posts: 4166 | From WA | Registered: Feb 2011
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posted
You all are super... you know, I always wanted a PhD and now I am finding... you end up getting the equivalent when navigating getting well from this challenge. That is what I am calling it these days.
Thank you Gi Gi and Razzle... I greatly appreciate the resources... Your #$%^ right I am going to beat this (smiles)!
Posts: 859 | From Southeast | Registered: Mar 2011
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nonna05
Frequent Contributor (1K+ posts)
Member # 33557
posted
I was muscle tested for this once..They said not needed.. Is an antioxidant ,so is it Ok to do with Mephron??
I think I just posted where taking Tylenol interferes with this mineral/amino?
I still trying hard to keep back from those Graemlins.....but their calling my name ,. Ha! Ha! Nonna
Posts: 2563 | From Denver,CO | Registered: Aug 2011
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posted
I have a blocked methylation detox pathway. I was one of the first to try the simplified protocol when Rick (Rich?) VanK brought it up at the Prohealth forum.
I felt better for about 2 months, and then it stopped. So, R VanK speculated that I had another blockage, and I had hit the bottleneck of the detox exit.
Later, I had a glutathione push, and didn't feel better at all. I told my LLMD that, and he immediately said, OK you have a blocked sulfuric detox pathway. What he did was add 2 mg. of molybdenum to the glutathione. I did feel better after that one.
I wasn't in any condition to retain an explanation, but some time, I'd like to know why the moly for a blocked sulfuric pathway, and also: Does Lyme disease cause these blockages, or are they genetic and figure in on how sick one gets when bit by a tick? Or, is it still in the chicken/egg phase and not yet known?
Maybe this could help you if you want to try the glutathyone again.
Posts: 552 | From New Mexico, USA | Registered: May 2007
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Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
You can have a detox block. I did the detoxigenomic liver test through Genova Diagnostic lab in NC and it showed that I have a glutathione detox block.
So I'm just taking it real easy right now, I think with a glutathione precursor, taking whey protein, if I recall correctly from my medical visits discussion.
I'm not much focused on the issue right now, since FIR sauna detoxing is going so well.
Posts: 13116 | From San Francisco | Registered: May 2006
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posted
I find that the first dose of iv glutithione gave me a very srong detox reaction.
I do a Meyers cocktail first then follow with the glutithione. I was very toxic from iv Vanco and doxy. So after doing it twice a week for a month it got better.
Now when I do it once a week I still have a detox reaction but not as intense. It usually takes a day or two to really feel like it is helping.
I really think this helped me move on in treatment. Anytime before I took my antibiotics it was like a tornado. Now I still herx my butt off but i am not completely out of my mind.
Posts: 253 | From CA | Registered: Jun 2011
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