I have been on multiple different orals for 20 months along with a few months of IV. 'Taking tons of supplements as well. Nothing has worked except the cipro which gave me some minor improvement, but had to stop it due to tendon issues.
I am on my second LLMD. 'Now looking to move onto a third. I asked my current LLMD to increase some of my doses, which he did and also switched me from doxy to mino. I am getting ready to begin this new combo today. Anyone have good experiences with it?
Anyone have any other ideas for me?
Thanks!
~tri
-------------------- ? date of bite/no rash 10/09 symptoms, 4/10 diagnosed, after 6 mos. ER visits, tons of docs/tests CDC+ 23/39/41/45/58/66/93 currently on oral plaquenil, doryx, rifampin, pyrazinamide, nystatin, numerous supplements Posts: 718 | From Pennsylvania | Registered: Jun 2010
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Define "good." I felt pretty terrible on a mino/flagyl/amoxicillin/malarone combination, but by the end of that cycle, I had made significant progress. So, in that sense, I had a great experience.
Posts: 447 | From Vermont | Registered: Jan 2011
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Tracy9
Frequent Contributor (1K+ posts)
Member # 7521
posted
Mino, Tindamax, and zith got my son well, but he took them for a year and a half and did 5 months of IV Rocephin as well. He wasn't completely consistent with the orals over the year and a half.
13 years Lyme & Co.; Small Fiber Neuropathy; Myasthenia Gravis, Adrenal Insufficiency. On chemo for 2 1/2 years as experimental treatment for MG. Posts: 4480 | From Northeastern Connecticut | Registered: Jun 2005
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Jeez, I wouldn't know since my MD only treats with one ABX at a time, and not even at what I would call high doses. It is becoming apparent that I may have to go out of state to get proper treatment. I will say this though, when I cut back on some of my supplements, I felt some improvement. I am down to only magnesium and CoQ10. Are you feeling consistently bad or is it possible some of this is from herxing?
Posts: 478 | From Third Coast | Registered: Feb 2011
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"Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi", Eva Sapi, Navroop Kaur, Samuel Anyanwu,David F Luecke,Ak****a Datar,Seema Patel, Michael Rossi Raphael B Stricker; Infection and Drug Resistance, 2011:4 97�113.
Comparison of invitro activities of tigecycline,doxycycline,andtetracycline against thespirochete Borrelia burgdorferi Louis Ates a, c, ChristaHanssen-H � ubner a, DouglasE.Norris b, DaniaRichter d, Peter Kraiczy a, Klaus-PeterHunfeld c.; Ticks and Tick-borne Diseases, (2010)30�34
Posts: 124 | From Maryland, USA | Registered: Jan 2010
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beths
Frequent Contributor (1K+ posts)
Member # 18864
posted
This is the conclusion of that study:
Results: Doxycycline reduced spirochetal structures ~90% but increased the number of round body forms about twofold. Amoxicillin reduced spirochetal forms by ~85%�90% and round body forms by ~68%, while treatment with metronidazole led to reduction of spirochetal structures by ~90% and round body forms by ~80%. Tigecycline and tinidazole treatment reduced both spirochetal and round body forms by ~80%�90%. When quantitative effects on biofilm-like colonies were evaluated, the five antibiotics reduced formation of these colonies by only 30%�55%. In terms of qualitative effects, only tinidazole reduced viable organisms by ~90%. Following treatment with the other antibiotics, viable organisms were detected in 70%�85% of the biofilm-like colonies. Conclusion: Antibiotics have varying effects on the different morphological forms of B. burgdorferi. Persistence of viable organisms in round body forms and biofilm-like colonies may explain treatment failure and persistent symptoms following antibiotic therapy of Lyme disease.
Posts: 1276 | From maryland | Registered: Jan 2009
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koo - Yes, unfortunately, consistently bad. I haven't herxed on ANYTHING, I don't think.
-------------------- ? date of bite/no rash 10/09 symptoms, 4/10 diagnosed, after 6 mos. ER visits, tons of docs/tests CDC+ 23/39/41/45/58/66/93 currently on oral plaquenil, doryx, rifampin, pyrazinamide, nystatin, numerous supplements Posts: 718 | From Pennsylvania | Registered: Jun 2010
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My final 4 months of treatment were minocycline, flagyl and clarithromycin. I felt absolutely dreadful the whole time, until about the last 2 or 3 weeks. But I finally turned the corner with that combo and I have been in remission since then (11 months) and have no more symptoms. Like you, I had tried many different combos (no IV) in the preceding 24 months and noticed very little improvement.
Posts: 41 | From Victoria, BC Canada | Registered: Jul 2009
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