Rumigirl
Frequent Contributor (1K+ posts)
Member # 15091
posted
What is the usual dosage given for TBD's for oral clindamycin? My doc rx'd it at 3 300 mg caps twice a day. The lower dosage caps (300 mg), obviously, so I can work my way up in dosage. It seems high (900 x 2).
So I started with 300 mg twice a day, and have upped one of the dosages to 600 mg.
I needed something to take with Mepron, since I can't take zith, due to tinnitus getting worse. I asked for Biaxin, but he probably felt that it would be likely to cause tinnitus, also. So I presume the clindamycin fills that role?
I also needed something to prevent the rifampin for Bart from becoming resistant, since I had to go off doxy, because of sun sensitivity issues for the summer. I've never heard of clindy being good for Bart, however. Would it help to prevent the rifampin from becoming resistant? (He doesn't seem to think this is an issue, but I do).
I now have to work harder to prevent Candida (I'm at full dose rifampin and taking rocephin, too). Yes, I do lots of probiotics and saccharomyces boulardii. I think I may double my dose of probiotics, which are already high. Yes, I'm taking high doses of nystatin, and have diflucan for when I need it.
I haven't even added Mepron back in yet, because I don't want to slam myself too hard. It's been hard enough as it is. Truthfully, I never had a hard time with Mepron though.
Posts: 3771 | From around | Registered: Mar 2008
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posted
I think it's whatever dose works to stop the symptoms. I used it to treat the Lyme. When I first started clinda, I went around the clock with 150mg every 6 hours for a month, then I herxed and dropped to 2x/day.
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Sammi
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Member # 110
posted
It is my understanding that Mepron needs to be taken with Biaxin or Zithromax for it to be effective. I don't think Biaxin has the possible side effect of tinnitus. You may want to research this and speak with your doctor.
I think there was a recent post about Rifampin significantly reducing the absorption of Mepron.
I take 600 mg Clindamycin twice a day along with other meds.
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sammy
Frequent Contributor (5K+ posts)
Member # 13952
Above is the link on clindamycin at rxlist.com, they give appropriate dosages for all infections.
They list 450mg every 6hrs for "more severe infections" (daily total 1800mg). This is the same total dose that you are taking at 900mg twice daily.
Sammi may be on other antibiotics that work well with the clinaimycin, that may be why her doc chose to RX a different dose. Same doc RX'd the 900mg BID dose for me.
Everyone is unique. Our LL docs are priceless for taking the time to figure out what it is that we all need as individuals to get better. Seems no one simple protocol works for all.
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sammy
Frequent Contributor (5K+ posts)
Member # 13952
posted
I personally would not worry about building resistance to the Rifampin since you are on the Rocephin and Clindamycin too.
The most important thing is to take the Rifampin every day. Stopping and starting is not good.
I did a quick search to find some answers for you and this was interesting. It's talking about TB patients, they are the ones that are primarily prescribed Rifampin or a combo of meds including Rifampin.
"Treatment of Chronic Infections with Rifamycins: Is Resistance Likely To Follow?"
"Conversely, prolonged treatment of patients with latent tuberculosis with a single agent virtually never results in the emergence of drug resistance (5). Several trials of rifampin for latent tuberculosis have been undertaken, and in none of these has rifampin-resistant tuberculosis developed in patients receiving monotherapy (9). For people with latent M. tuberculosis infections, the estimated bacillary burden is less than 104 organisms (4, 13); thus, innately resistant clones are not likely to be present, and monotherapy with a single antituberculosis drug will not lead to the selection of resistant organisms. In fact, rifampin therapy for latent tuberculosis is highly effective and prevents the development of clinical tuberculosis. Individuals with latent tuberculosis who are treated with rifamycins for indications other than prophylaxis will still benefit with respect to the prevention of active tuberculosis."
Obviously this is copy and paste, not my words. Follow the link for the full article.
For purpose of treating Babesia and Bartonella it might be best if you can try to switch your protocol around later on (after you're done seeing improvements and have plateaued.) But for now, give the Clinda a try for a couple months. That will give you and your doctor to think about what to do next.
Posts: 5237 | From here | Registered: Nov 2007
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Rumigirl
Frequent Contributor (1K+ posts)
Member # 15091
posted
Thank you, guys. Thank you, sammy, for the link. I had looked it up in the PDR, and it said the same thing about the dosage. I certainly have plenty of a load to go after. But I'm going up slowly to avoid being slammed any further than I have been. Thank God for glutathione!! It's really helped a lot to deal with the die-off.
Interesting what the link says about TB not becoming resistant to rifampin. I just fear that in general, because the docs and guidelines usually stress that so much. I already have several classes of meds that I can't take, so my choices are limited. So I don't want to create resistance to the ones that I can take.
I have to say that the process of very slowly ramping up on the meds makes ALL the difference for me! It's a real eye-opener.
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