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» LymeNet Flash » Questions and Discussion » Medical Questions » Experience with Sam-E??

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Author Topic: Experience with Sam-E??
tricia386
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I see that Dr.B recommends Sam-e. Does anyone have any experience with it? Did you see any results in mood,fatigue,or joint paint??

Hate to waste money on another supplement!

--------------------
Lyme activated in April 2010 by gardasil vaccine.
DX: Lyme,Babs,Myco,Bart 11/10
Treatment Started: 3/28/11

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willbeatthis
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Hi Tricia: This is one supplement I have not been without for many years. Long story short, about ten years ago, well before lyme I fell and broke my foot.... and was on vioxx until I had to be taken off of it due to increased liver enzymes. My doc said, I don't care what you do, but you can't do vioxx anymore so ice etc... in essence deal. Well, I was in chronic pain and that was not welcome advise. It seems to me that it was not too distant in the future that I saw an article in prevention on natural antinflams and same ee with primrose oil was said to be as effective as vioxx... well, I found them more so. I take 400 mgs of sam ee with 1300 mg of primrose oil from GNC on empty stomach every morning and evening... I take them with lumbrikanase, cur cumin, nrf2 and wobenzm. Yes, I do not think about the cost I just keep working so that I can pay it.... They have been invaluable to me. I hope this helps....
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tricia386
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Did it help with mood or just inflamation??

Thanks for your response

--------------------
Lyme activated in April 2010 by gardasil vaccine.
DX: Lyme,Babs,Myco,Bart 11/10
Treatment Started: 3/28/11

Posts: 1752 | From Albany, NY | Registered: Dec 2010  |  IP: Logged | Report this post to a Moderator
annxyzz
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It helps with mood IF taken on an empty stomach . You mmust have a normal level of B VIT , esp B 6 for it to be a mood lifter .

It does help with mood though and increases dopamine and serotonin and I think norepinephrine. If you have serious depression you must take a HIGH dose 1200 mg , which would cost a lot . I take 400 mg daily and I also take a low dose AD . If I did not take SAM E I would need a higher dose of Zoloft . Also , SAM E is hepaprotective (liver) and helps raise glutathione. Most of us have a serious depletion
of GLUTATHIONE , which is a BIG (!) problem .

The SAM E really helps with keeping muscles and joints limber . If I skip it a while, I feel it in a major way . I also feel it helps me be more optimistic with a lousy disease. Wish it were cheaper ! I buy nature made and like the quality, but doctor's formula is well reviewed at iherb and cheaper .

For depression, I have read reviews at iherb about 5HTP by NOW that has great reviews from many people . I have not tried it , but reviews are impresive.

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annxyzz

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tricia386
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Thank you both for your response. What intrigued me about Sam-e is that I have HIgh Homocystiene levels and that is usually an indicated of undermethylation and Sam-e is a big supplement to help that.

Maybe I will try it out with my LLMDS approval of course!

--------------------
Lyme activated in April 2010 by gardasil vaccine.
DX: Lyme,Babs,Myco,Bart 11/10
Treatment Started: 3/28/11

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willbeatthis
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Hi Tricia: I think it helps with both too... I wouldn't be without it. Best,
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tricia386
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Well, my LLMD said I could try it. I will report back after a week or so and let you know how it is.

Does anyone know how long it takes to work?

--------------------
Lyme activated in April 2010 by gardasil vaccine.
DX: Lyme,Babs,Myco,Bart 11/10
Treatment Started: 3/28/11

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nefferdun
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With my methyl cycle mutations there are some supplements I cannot tolerate. SamE is one of them. What works for one person does not always work for someone else.

--------------------
old joke: idiopathic means the patient is pathological and the the doctor is an idiot

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tricia386
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Do you have the MTHFR gene?? I was tested and do not have one but have the other dreaded HDLA gene [Embarrassed] (

--------------------
Lyme activated in April 2010 by gardasil vaccine.
DX: Lyme,Babs,Myco,Bart 11/10
Treatment Started: 3/28/11

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tickled1
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I'm confused. I also thought I read with MTHFR that Sam-e should be avoided and I know with MTHFR there is elevated homocysteine.
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tricia386
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I can actually lower Homocystine levels from what I read.

Since SAMe is ultimately converted in the body to homocysteine, it is theoretically possible that taking it could elevate homocysteine levels. But that doesn't happen. In fact, SAMe actually appears to lower homocysteine by helping the body metabolize it. A small study (with only 15 volunteers) at McLean Hospital in Belmont, MA looked at the effects on homocysteine after taking daily doses of 1600 mg of SAMe for four weeks. Homocysteine levels were measured at the outset and at the end of the second and fourth weeks. None of the study participant's homocysteine levels increased.

An ongoing study at Baylor University is evaluating the effect of taking 1,200 mg of SAMe daily when homocysteine levels are already somewhat elevated. Results are not yet in.

Homocysteine levels tend to be higher in people who eat a lot of animal protein and whose diets are low in fruits and leafy vegetables, which provide folate and other B vitamins the body needs to process homocysteine. Some evidence suggests that the higher the blood levels of B vitamins, the lower the concentrations of homocysteine, and that low blood levels of folic acid are associated with a higher risk of fatal coronary heart disease and stroke.

I wouldn't worry about any effect that SAMe might have on your homocysteine levels, but if you take it, you should also reduce the amount of animal foods in your diet and make sure that you get plenty of vitamins B6, B12 and folate. Take a daily multivitamin supplement that provides 400 mcg of folic acid, at least 50 mg of vitamin B6 and 50 mcg of B12 (along with the rest of the B-complex). Since B12 isn't always well absorbed through the stomach, you might consider taking it in spray form or sublingually (tablets that dissolve under the tongue).

Good dietary sources of folate are spinach, asparagus, broccoli, turnip greens, citrus fruits and juices, dried peas and beans, as well as breakfast cereals and other foods made with fortified flour.

Andrew Weil, M.D.

--------------------
Lyme activated in April 2010 by gardasil vaccine.
DX: Lyme,Babs,Myco,Bart 11/10
Treatment Started: 3/28/11

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tickled1
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For those w/MTHFR, regular folic acid and B12 are not a good idea. The active or methylated forms are necessary since those w/MTHFR can't convert them to their active form.
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tricia386
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Right I know that. I do not have the MTHFR Gene.

Thats why i thought i would try it as Dr.B recomends it as one of his supplements. For depression and joint and tendon pain.

--------------------
Lyme activated in April 2010 by gardasil vaccine.
DX: Lyme,Babs,Myco,Bart 11/10
Treatment Started: 3/28/11

Posts: 1752 | From Albany, NY | Registered: Dec 2010  |  IP: Logged | Report this post to a Moderator
tickled1
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Gotcha.

My LLMD did mention that even w/out MTHFR it is better to take them in their more bio-available form.

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tricia386
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Yes, Tickled1 my LLMD said the same thing maybe we have the same LLMD!

--------------------
Lyme activated in April 2010 by gardasil vaccine.
DX: Lyme,Babs,Myco,Bart 11/10
Treatment Started: 3/28/11

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tickled1
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CT?
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tricia386
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No Hyde park

--------------------
Lyme activated in April 2010 by gardasil vaccine.
DX: Lyme,Babs,Myco,Bart 11/10
Treatment Started: 3/28/11

Posts: 1752 | From Albany, NY | Registered: Dec 2010  |  IP: Logged | Report this post to a Moderator
   

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