LymeNet Flash: The WFL's ability to destroy Bb

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»	LymeNet Flash » Questions and Discussion » Medical Questions » The WFL's ability to destroy Bb

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Topic: The WFL's ability to destroy Bb

Marnie
Frequent Contributor (5K+ posts)
Member # 773

posted

The Western Fence Lizard's ability to destroy Bb depends on 2 things...light (intake...nonstop!) AND PDE6.

Here is why:

The WFL must see at night when it hunts for insects to eat and be able to grasp whatever available light there is (hence more eye rods).

(Eye cones enable US to see colors.)

That light triggers PDE6 which

reduces the levels of cGMP.

Light -> PDE6 -> lower cGMP.

cGMP modulates the *demethylation reaction* responsible for

adaptation to stimuli.

http://www.pnas.org/content/77/7/3879.full.pdf

While Bb depends on light and is likely photosynthetic - ongoing light destroys him because light triggers PDE6 which lowers cGMP (and keeps it low!).

So...those searching for the protective enzyme/protein in the WFL should look for PDE6, IMO.

If they want to GROW Bb in a lab (hard to do), put Bb on an nuutrient rich agar dish in a dark room and use strobe lights to trigger growth.

I believe Bb has what is called bacteriorhodopsin.

Getting more specific:

Halobacteria, when exposed to light in the absence of oxygen, can synthesize a purple membrane containing a single photosensitive protein called

bacteriorhodopsin

which, when illuminated, begins cyclic bleaching and regeneration, extruding protons from the cell.

This light-stimulated proton pump operates without electron transport.

Too much light ongoing, non-stop, is deadly to Bb.

Bb is not that much different than us...we need light, but we also need darkness.

There are many bacteria deep in the oceans that have adapted to living/surviving in dark conditions.

AND...this is fascinating:

"Examples of circadian rhythms have been described in eukaryotic organisms and in

photosynthetic bacteria"

http://www.jcircadianrhythms.com/content/8/1/8

Perhaps Bb is like us...sleeps, rests (is still alive) in the dark, but wakes up in the light?

Oddly evolution was thought progress from simple organisms (Archaea) to more complex ones.

But researchers have found the reverse is true.

More complex organisms (spirochetes) happened FIRST.

"We present statistically significant evidence that the ***root of life*** is outside the Archaea."

http://mbe.oxfordjournals.org/content/23/9/1648.full.pdf

Going back to lower cGMP...

�If the adaptation process is directly
responsible for this return,

an elevated degree of MCP methylation should cause a decrease in the cGMP level

whereas a reduced degree of MCP methylation should increase this level.�

http://www.pnas.org/content/77/7/3879.full.pdf

Reversing the above should mean decreasing cGMP
-> increased MCP methylation.

MCP = *methyl-accepting* chemotaxis *proteins*

This MCP methylation system is instrumental in enabling the cell to carry out sensory ***adaptation***after a chemotactic response.

Light lowers cGMP -> increased methylation of certain proteins (MCP) -> adaption happens.

Then the lower availability of �methyl� (less MCP methylation 'cause it is attached to proteins) -> increased cGMP.

But NONSTOP light may prevent that conversion by keeping cGMP levels LOW -> increased methylation .

As many of you already know, in lyme disease there is a �methyl�/ Methylation (CH3) problem.

If we can increase the availability of �methyl� in undermethylated defense cells, perhaps this is the key to eliminating Bb.

OUR DNA-methylation:

It�s like hitting the "on" switch on a computer; DNA methylation is the operating system of the body, helping it to regulate important processes such as cellular growth and repair, production of immune cells to fight disease, wound healing, and reproduction.

The undermethylation of DNA is believed to be a causal factor in cancer,

because it could hamper the body�s ability to repair damaged cells before they turn cancerous.

http://www.newmediaexplorer.org/sepp/2006/06/11/same_methylating_agent_stops_depression_hiv.htm

Inhibition of myocardial glucose uptake by cGMP

http://www.ncbi.nlm.nih.gov/pubmed/9612348

If Bb needs glucose AND amino acids, Bb HAS to upregulate the levels of cGMP.

So low cGMP ONGOING...no glucose goes into the cells, but in order for the cells to survive... amino acids import takes place.

Cancer cells do not survive on glucose, they have adapted/been mutated (DNA damage...undermethylated) and survive on amino acids instead.

Kundalini = the energy or life force within us.

Look at the "under-methylated" biology connection here (use your edit key to find under-methylated):

http://biologyofkundalini.com/article.php?story=Histamine

That's the change Bb triggers....low levels of neurotransmitters, etc.

This is the basis for methotrexate (which impacts folic acid).

Understand/know the enemy.

P.S.

Computer geeks will like this link (me�holy cow!):

http://wiki.answers.com/Q/Computer_memory_based_on_the_protein_bacterio-rhodopsin

Posts: 9424 | From Sunshine State | Registered: Mar 2001 | IP: Logged |

Catgirl
Frequent Contributor (5K+ posts)
Member # 31149

posted

Maybe it's something simple, like heat. Those things sit out in the sun all day and bake. Or maybe it's that and D3 (don't know lizards do that though).

--------------------
--Keep an open mind about everything. Also, remember to visit ACTIVISM (we can change things together).

Posts: 5418 | From earth | Registered: Mar 2011 | IP: Logged |

Marnie
Frequent Contributor (5K+ posts)
Member # 773

posted

That lizard is very unique...it has a cyan colored (bright blue) underside.

Many of the really toxic amphibians in the world have bright colors.

The bright colors warn potential predators of their toxicity.

Bb (inside the tick) didn't see it coming.

Posts: 9424 | From Sunshine State | Registered: Mar 2001 | IP: Logged |

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