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» LymeNet Flash » Questions and Discussion » Medical Questions » Best way to really improve glutathione?

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Author Topic: Best way to really improve glutathione?
CD57
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I read that toxins and infections are mostly problematic only when you are low in glutathione...a doc told me this once, and says it's a common denominator across all chronic illnesses. They see it in HIV patients all the time.

Has anyone found a way to affordably really increase their glutathione, verified by Spectracell or other test? IV glut, while great, apparently gets eliminated by the kidneys fairly quickly and does not raise the intracellular levels.

This could be extremely key for all of us, getting it up. I think the methylation problems play into this as well.

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Razzle
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Supporting good methylation should increase glutathione.

Dr. Yasko says we need all of the following to support good methylation:

1. Antioxidants (Vit. A/C/E, Zinc, Selenium, pycnogenol, N-Acetyl-Cysteine, L-Carnitine, etc.)

2. B-Complex Vitamins

3. Vitamin K & D

4. Essential Fatty Acids (Omega-3's - fish oil)

5. Minerals: Molybdenum, Magnesium, Zinc, & other minerals

6. SAM-e, NADH

7. Phosphatidylserine & phosphatidylcholine (found in lecithin)

8. Reduce exposure to environmental toxins (EMF's, household cleaning chemicals, pesticides, artificial perfumes/air fresheners, etc.)

9. Eat a clean, balanced diet (no GMO's, pesticides, preservatives, MSG, other artificial additives, etc.)

10. Improve digestion (digestive enzymes, TMG/Betaine, probiotics, fiber)

11. Kidney & Liver Support (dandelion, parsley, milk thistle, etc.)

12. Sufficient water intake

13. Exercise (deep breathing, resistance exercises, etc., as tolerated)

14. Deal with heavy metals, if applicable

15. Deal with methylation genomic variants (using targeted nutrition protocols), if applicable

16. Ammonia detoxification (yucca, charcoal) - Lyme creates excess ammonia

17. Binders (to aid detoxification; includes charcoal, chlorella, bentonite, etc.)

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-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

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CD57
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Thanks Razzle! Has anyone found something easy that really does work? Yasko's stuff is intimidating due to volume of supps....

whey protein? precursors?

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Razzle
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Methyl donors (e.g., methylcobolamin, 5-methyltetrahydrofolate, TMG, etc.) will speed up the reaction that creates glutathione.

One also needs methionine and cysteine (amino acids) to make glutathione.

Those are the essential ingredients.

What gets complicated is when there are things that impact the function of the methylation cycle that creates the glutathione.

This is why the Yasko protocol is so complicated - it is trying to compensate for genetic and environmental factors that affect the ability of the methylation cycle to function correctly.

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-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

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nefferdun
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Dr. Roberts (not an LLMD) of the heartfixer site, advises patients on the methyl cycle mutations, and he recommends Life Wave Glutathione patches. I have been using them off and on for 8 months. I don't have test results to prove they work but I am much better - off drugs.

The patches are supposed to work like acupuncture to stimulate your body to produce more glutathione. They are expensive but Dr. Roberts says you can wear each patch 48 hours, which makes them much more affordable.

As Razzle said, you need to open the pathways so you can produce the glutathione. If you have a CBS mutation (and 80% of us do), you need to start with strict diet control. Vegan is best. You can read all about it on his site.

--------------------
old joke: idiopathic means the patient is pathological and the the doctor is an idiot

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CD57
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Is the CBS mutation the sulfur one? Doc thinks I have that.

These patches sound very interesting....

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vitamink
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There's a simplified version of the Yasko protocol which includes:

1. General Vitamin Neurological Health Formula [2]: Start with one-quarter tablet and increase dosage as tolerated to 2 tablets daily
2. Hydroxy B12 Mega Drops [3]: 2 drops under the tongue daily
3. MethylMate B [4]: 3 drops under the tongue daily
4. Folinic acid [5]: one-quarter capsule daily
5. Phosphatidyl Serine Complex [6]: 1 softgel capsule daily (or lecithin, see below)

http://www.mecfsforums.com/wiki/Simplified_Methylation_Protocol,_Rich_Van_Konynenburg

My doc tweaked the protocol and I ended up taking just B12 (as methylcobalamin), methylfolate, folinic acid and phosphatidylserine.

After a few months, my glutathione rose from 2.6 to 3.5 micromol/L (ref range 3.8-5.5) as measured by the Methylation Pathways Panel from the Health Diagnostics and Research Institute.

-Karina

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shannon12
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So I'm confused pretty much iv glut is useless now? or doesn't do too much?

[ 11-08-2012, 08:01 PM: Message edited by: shannon12 ]

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gigimac
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will glut help if you don't have a methylation defect?
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CD57
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Goog question gigimac.

Shannon, the IV glut usually helps people feel better but is not apparently a proven or cost effective way to raise the levels intracellularly. The research I read says the kidney remove the IV glut from the blood before it can do much. We're better off doing other stuff to raise levels.

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Razzle
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The simplified methylation protocol does not work for everyone - especially those with CBS variants.

It is best to get tested for methylation genomic variants first so you know which issues you have to deal with regarding methylation.

No, I do not have any financial interest in methylation testing or supplements. I'm simply aware of the extreme complexity of this issue due to my own struggles with methylation.

--------------------
-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

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