Topic: Genetic Profile Test Results (MTHFR and more)
canefan17
Frequent Contributor (5K+ posts)
Member # 22149
posted
A few months back I had an MTHFR test done to look into methylation cycles and folate utilization, etc.
After those results I decided to dig deeper with a comprehensive panel test. Got my results today and sent them to someone who understands how to read it.
Homozygous (2 copies) for the following... COMT - V158M COMT - H62H MAO A - R297R MTHFR - C677T
She responded with this... "Well you dont stimulate your neuroreceptors because of mthfr; you use up your dopamine like crazy due to comt and you dont release any serotonin that you do make. I bet you are a moody person with addictive tendencies!"
She nailed me. I've always had an addictive personality and growing up mood swings (especially when combined with alcohol e.g. HS & College!) were an issue for me.
I don't know what to do really (other than folate for MTHFR) but I'm hoping someone here has some experience or insight (nefferdun or MariaA)
Anywho...
Posts: 5394 | From Houston, Tx | Registered: Aug 2009
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tickled1
Frequent Contributor (1K+ posts)
Member # 14257
posted
Canefan,
May I ask which test you had done? I did the standard MTHFR test and found out I am Homozygous C677T. I'd like to know what other MTHFR issues I have though without breaking the bank.
Posts: 2541 | From Northeast | Registered: Jan 2008
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Razzle
Frequent Contributor (1K+ posts)
Member # 30398
posted
Need co-enzyme forms of B Vitamins (all of them, not just the methyl-folate).
Vitamin B12 in large doses. Hydroxy-B12, Methyl-B12 are best forms. Since you're under-methylated (MTHFR mutation), Methyl-B12 is probably the better form but should take both.
SAM-e may help with the mood stuff.
Also need Fish Oil / Omega 3's and Vitamin D.
Kidney and liver support may also be helpful - consult a Naturopathic physician for this because each person is unique and what may help one may not work for another...
-------------------- -Razzle Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs. Posts: 4166 | From WA | Registered: Feb 2011
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canefan17
Frequent Contributor (5K+ posts)
Member # 22149
posted
tickled,
I did Amy Yasko's comprehensive Genetic Panel
Dr Ben Lynch has some info on it as well
Posts: 5394 | From Houston, Tx | Registered: Aug 2009
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Did Amy Yasko interpret her test results for you or did someone else?
Posts: 538 | From kentucky | Registered: Nov 2011
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Razzle
Frequent Contributor (1K+ posts)
Member # 30398
posted
PM sent...
-------------------- -Razzle Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs. Posts: 4166 | From WA | Registered: Feb 2011
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sammy
Frequent Contributor (5K+ posts)
Member # 13952
posted
I need to learn more about this too and get tested. My mother just tested double positive for the C677T mutation and was diagnosed with hyperhomocysteinemia.
She recently developed 8 blood clots down her leg that sealed off and killed the entire vessel. Good doctors have never seen anything like it before. Pretty scary. They only have her on aspirin for the clots. Now after the diagnosis I begged her doctor to prescribe Metanx for the absorbable methyl B12, p-5-p, and L-methlyfolate (per Dr. Lynch site).
She's waiting to see a geneticist for further treatment. The hematologist said that this is dangerous because without proper treatment this double gene increases risk of clotting and risks of silent heart disease. Basically people drop dead. Which is exactly what we have seen in my family. My grandpa 54, my uncle 49, my 30yr old cousin. Pretty scary.
I already see a geneticist for another genetic disorder, Ehler's danlos syndrome, so I will request tests at my next follow-up in Oct. I just want to make sure that my family gets all the tests that we need. And the right treatments.
Thanks.
cane, I hope you don't get upset with me posting on your thread. Your questions need answered first. I just thought that since we are all dealing with the same C667T mutation that we all need this information too so I hated to start a new thread and break it up.
Posts: 5237 | From here | Registered: Nov 2007
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tickled1
Frequent Contributor (1K+ posts)
Member # 14257
posted
Great, now I'm TERRIFIED!!! b/c that is the mutation I have-also 2 copies. Maybe I should get myself on enzymes now. Does anyone know if that is the way to go for me? I'm 36. What can I do to prevent the clots/heart disease?
Posts: 2541 | From Northeast | Registered: Jan 2008
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canefan17
Frequent Contributor (5K+ posts)
Member # 22149
posted
Systemic enzymes saved my arse. Boluoke and Serrapeptase (by Serratia)
yes homozygous MTHFR requires anti-coagulants and methylfolate.
In all my years of treating (only 3) the most powerful supplement I've ever taken is Boluoke.
Probably goes to show you how THICK my blood was. And I'm 5'11 135 lbs lol
Posts: 5394 | From Houston, Tx | Registered: Aug 2009
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canefan17
Frequent Contributor (5K+ posts)
Member # 22149
posted
soccermama,
No she didn't.
sammy, No problems at all
Posts: 5394 | From Houston, Tx | Registered: Aug 2009
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tickled1
Frequent Contributor (1K+ posts)
Member # 14257
posted
Have you felt better sinced starting the enzymes?
I am taking B Supreme by Designs for Health. I believe this covers all bases with the B12 and folate.
Posts: 2541 | From Northeast | Registered: Jan 2008
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Tammy N.
Frequent Contributor (1K+ posts)
Member # 26835
posted
I am homozygous for MTHFR also. At first I was tripped out, then I realized there are so many different ways our bodies create detours to correct dysfunctions in our system. Unmeasureable ways.
The doc who did the bloodtest for me explained that I needed the methylated version of folate, etc. etc. Because docs don't seem to know much about it, to be on the safe side, I had my local LLMD run tests on my folate, and B12. Well, they were high (too high on the B12). So supplementing would not have been good for me.
I would like to learn more about it, but it has shifted to a lower priority.
Long story short, I decided not to worry about it and instead found a doc that does ART testing and FINALLY I am getting much much better. For me, treating parasites has been the big turnaround. Wish I took this path long ago.
Posts: 2238 | From East Coast | Registered: Jul 2010
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tickled1
Frequent Contributor (1K+ posts)
Member # 14257
posted
In 2009 my B12 and Folic Acid were actually high as well but we are theorizing that that was b/c I actually was not converting it to the active form so even though it showed high I was actually deficient b/c my body couldn't use it.
Posts: 2541 | From Northeast | Registered: Jan 2008
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sparkle7
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Member # 10397
posted
Interesting Tammy. I though about testing but I don't know. All of this is fine & good but it might be the pathogens that are the real problem.
Posts: 7772 | From Northeast, again... | Registered: Oct 2006
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canefan17
Frequent Contributor (5K+ posts)
Member # 22149
posted
What tickled said.
I had mineral hair analysis done and my magnesium was off the charts high. But lord knows I was deficient in magnesium... it wasn't getting to the cells, receptor sites, etc.
Posts: 5394 | From Houston, Tx | Registered: Aug 2009
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sparkle7
Frequent Contributor (5K+ posts)
Member # 10397
posted
How do you know? I don't know how accurate these hair tests are - as well. It's hard to say...
Posts: 7772 | From Northeast, again... | Registered: Oct 2006
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