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» LymeNet Flash » Questions and Discussion » Medical Questions » confused, difference between KPU, methylation, and hla?

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Author Topic: confused, difference between KPU, methylation, and hla?
gigimac
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I want to get a bit of testing done to see if there are some things that can be tweaked and helped with supplements diet change etc.

I discussed hla and kpu and methylation with my doc. she plans on doing some kind of hla test but not the others. I left the office still confused.

I also wanted to get my adrenals and hormones checked and the only thing she suggested was checking cortisol levels.

I am so confused and just want to get a good idea of what my body is lacking and needs to feel better.

Can anyone explain the difference or give the names of the specific testing I would need to find out if i have a methylation issue and the kpu problem. what tests for adrenals?

Posts: 1534 | From Greensboro NC | Registered: Aug 2011  |  IP: Logged | Report this post to a Moderator
Razzle
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KPU is some kind of mutation with red blood cell hemoglobin and results in a severe zinc deficiency, essentially. I don't know what specific test(s) are involved with this.

Adrenal tests needed: fasting 8am cortisol, DHEA, DHEA-s, and pregnenolone.

Methylation tests:

Dr. Yasko's Comprehensive Methylation Panel
http://www.holisticheal.com/comprehensive-methylation-panel-with-methylation-pathway-analysis.html

-no doctor prescription required
-finger stick can be done at home

Other tests that can assess your nutrition status:

NutrEval from Genova Diagnostics
http://www.gdx.net/product/10051

-tells glutathione and antioxidant status, fatty acid status, vitamin & mineral status, and toxicity levels (candida, bacterial dysbiosis in the gut, plastics/other toxins, heavy metals)

Methylation is the process by which a methyl group is added to something. Methylation is needed for energy metabolism, detoxification, folic acid conversion, genetic protection, nerve function, amongst many other things.

Poor methylation results in increased risk of aging, chronic disease, metabolic problems, alzheimer's, heart disease, stroke, cancer, autoimmunity, impaired detoxification, and many other issues.

Edited to add:

HLA is Human Leukocyte Antigen, which is referring to different genetic profiles of one's ability to detoxify Lyme and/or Mold toxins. I don't know what tests are needed for this...

--------------------
-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

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gigimac
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Thank you so much Razzle! That helps a lot!!
Posts: 1534 | From Greensboro NC | Registered: Aug 2011  |  IP: Logged | Report this post to a Moderator
gigimac
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I took the questoinnaire for kpu and the answer came back that it was unlikely i had it. Should i still pursue this?
Posts: 1534 | From Greensboro NC | Registered: Aug 2011  |  IP: Logged | Report this post to a Moderator
gigimac
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If there are any other tests that anyone would think helpful feel free to add!!
Posts: 1534 | From Greensboro NC | Registered: Aug 2011  |  IP: Logged | Report this post to a Moderator
Catgirl
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Right on Razzle!

--------------------
--Keep an open mind about everything. Also, remember to visit ACTIVISM (we can change things together).

Posts: 5418 | From earth | Registered: Mar 2011  |  IP: Logged | Report this post to a Moderator
Razzle
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Hemex Laboratories' ISAC (Immune System Activation of Coagulation) test panel and Hereditary Hypercoagulation test panel.


Comprehensive Immune Workup:

WBC w/ Differential (including absolute counts)

Immune Globulin levels: Total IgG (and subclasses), Total IgA (and S-IgA), Total IgM, Total IgE

Lymphocyte Subsets (CD4+ & CD8+ T-Cells, B-Cells, CD56+ NK Cells, CD4:CD8 T-Cell Ratio)

Complement levels - including C3a & C4a


Anemia Workup, if anemia is an issue (this includes Iron Panel in addition to the usual RBC stuff).


Eosinophil Cationic Protein (ECP) level, if Babesia may be an issue...


Labcorp's CD-57 ("stricker panel") may be useful for tracking progress with treatment...some LLMD's find it useful, others don't.

--------------------
-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

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ktkdommer
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My son didn't test positive for KPU but had close to 30 clouds in his nails. He started The Core and a year later he is down to 5 clouds. That was our test for KPU.

--------------------
Things are never dull. After 3 fighting Lyme, 2 are in remission. Youngest is still sick, age 22. He has new diagnosed Chiari Malformation and Ehlers Danlos Syndrome.

Posts: 1366 | From Perrysburg, Ohio | Registered: Nov 2010  |  IP: Logged | Report this post to a Moderator
   

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