posted
I am really worried. My OBGYN put me on Sporanox (Itraconazole) 200 mg BID for two weeks along with Diflucan 100 mg once a day for 7 days and then once a week for four weeks for a bad yeast infection. I have been off all ABX since early October due to some complications, but I am planning to start pulse dosing again tomorrow.
I finished the Sporanox over a week ago, but I am still experiencing a significant worsening of the peripheral neuropathy that I have had for 17 years. I have read that Sporanox can cause PN or cause it to worsen in folks who already have PN.
I am really scared that this worsening episode may not be an episode. It may be permanent. I have read that sometimes drug-induced PN is permanent even after cessation of drug treatment.
Shame on me because I noticed worsening when I started taking it (after first dose), but I didn't think anything of it. I just figured that it was a side effect that I needed to tolerate while on the drug. It made me feel heightened neuro symptoms throughout my body (the feeling of low level electricity going through my body increased and no longer felt isolated to my legs).
I am so scared that this increase in symptoms won't go away. I work full time and cannot afford this level of increase in pain.
Does anyone have any advice or wisdom on this issue? I already take Methylcobaline injections, High dose magnesium, acetyl-L-carnitine, ubiquinol, etc. for the PN, but none of it seems to be helping anymore since I have been on the Sporanox.
I have also been on 0.5 mg of clonazepam at night for over a decade to deal with the PN symptoms. That doesn't seem to be helping as much either.
Thanks in advance for any advice or info.
Posts: 52 | From Central VA | Registered: Jun 2011
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sammy
Frequent Contributor (5K+ posts)
Member # 13952
posted
Sounds like you had a pretty bad infection that needed to be treated. When it comes to fungal infections, there are times when we have no good alternative medications that are effective.
I honestly wonder if you neuro symptoms might be getting worse because you had to be off antibiotics for so long? Not just because you took the sporanox+ diflucan combo?
I have severe neuropathy and mine always gets worse after a few weeks off antibiotics or if I'm not on an effective, strong enough Lyme antibiotic.
I've also been on sporanox and thankfully never experienced the neuropathy side effect though.
So you may be experiencing both side effect and a flare in symptom from being off antibiotics. It is worth talking with your Lyme doc about.
Vit b6 and ALA are also supposed to help with neuropathy. You may add those if you are not already taking them.
Take care. Hopefully things will get better with time and treatment.
Posts: 5237 | From here | Registered: Nov 2007
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posted
Sammy - Thank you. I don't think it is being off the ABX that caused the flare of the PN. As I have been of ABX since mid-Oct and not noticed a significant increase in the PN. However, I noticed that the PN was somewhat worse with the first dose of the antifungal. I should have stopped after the first dose. I am so discouraged. Thank you for your supportive message. I am going to call both my LLMD and my neurologist. Thanks again.
Posts: 52 | From Central VA | Registered: Jun 2011
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Tammy N.
Frequent Contributor (1K+ posts)
Member # 26835
posted
PN was my worst symptom. I had a major flare when I was put on Nystatin. Then I learned that some of the anti-fungals hit parasites. Maybe that's what Sporanox is doing to you.
For me, I ended up having a massive parasite infection, unbeknownst to me....that I am still treating (6+ months and counting). Since treating, my PN symptoms have gone way down.
Feel better. Best to you.
Posts: 2238 | From East Coast | Registered: Jul 2010
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posted
Thank you everyone. Tammy, I am very interested in your experience with the parasites. How did they diagnose you? What are they using to treat you? Are you also on antibiotics?
Posts: 52 | From Central VA | Registered: Jun 2011
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Tammy N.
Frequent Contributor (1K+ posts)
Member # 26835
posted
Hi axseptants. My diagnosis came from ART testing (it's a form of energetic testing). Stool testing is notoriously inaccurate so don't even bother with that. If you don't have access to a practitioner who does ART testing, I would treat and see what happens. (Check out some of my past posts, and also all the many posts of glm1111, she has been wonderfully supportive in this area.)
I seem to be having just as good results with herbals as I've had with medicine. This is what I did: Several rounds of different meds that were rotated....Biltricide (2 days), followed by Ivermectin with Pyrantel at night (2 weeks), followed by Albenza (2 weeks), and Alinia (2 weeks). I started passing parasites right away (large obvious worms). For the past 3 months I've just been doing an herbal tincture (Para A) and salt/c. I'm still passing parasites daily. I can hardly believe it myself. It's been almost 7 months. If you decide to go the herbal route, I think it is necessary to add salt/c in order for it to truly be effective. glm1111 was on herbals alone for 6 months and saw nothing, but once she started adding salt/c, she said "all hell broke loose". She treated for several years and now does maintenance. And she is well after over 30 years of sickness!!
I had no idea that parasites were such a big part of our picture. I believe that it may be the primary reason why most of us are ill and unable to get over Lyme and co-infections.
I had NO CLUE I had such a massive parasite infection. I cannot overstate it....without a doubt I think you should pursue parasite treatment. (For some reason, it seems that most people pay little attention to this.... I cannot for the life of me understand why.)
Also, I noticed you are new to Lymenet. If I may suggest.... I would read as many posts as you can of GiGi's. In my opinion, she is the most knowledgeable person on this board. She has a long-standing relationship with the best doctor in this field (Dr. K. ) and she posts extensively on all she has learned. There are so many aspects to this illness (infections, deficiencies, heavy metal toxicity, EMFs, mold, parasites, detoxing issues, etc.) and GiGi has the most knowledge. She has been enormously helpful to me. I feel grateful for all of her teachings.
Best to you.
Posts: 2238 | From East Coast | Registered: Jul 2010
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