Topic: Beware of OVERMETHYLATION ( deplin- folate )
annxyzz
Frequent Contributor (1K+ posts)
Member # 20404
posted
I have been reading at MTHFR.NET advice by "Dr Bob " who provides info on methylation .
He advises that it is best to start LOW with deplin/ optimized folate ( converted form ) because a person can quickly become overmethylated and his neurotransmitters can become too high along with thyroid , which would put a person tempoarily in a state of feeling a bit anxious. If this occurs , take 50 mg NIACIN to mop up excess methyl.
Some people need to lower their thyroid and antidepressant meds once they start the deplin or deplin substitute . If a person feels overstimulated , it may be that it has quickly started to work and has raised the levels of meds - potentiated them . I think some "tinkering " is needed in some cases . That is why starting low is advisable.
-------------------- annxyzz Posts: 1178 | From East Texas | Registered: May 2009
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Catgirl
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Member # 31149
posted
Wow, thanks ann!
-------------------- --Keep an open mind about everything. Also, remember to visit ACTIVISM (we can change things together). Posts: 5418 | From earth | Registered: Mar 2011
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sparkle7
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Member # 10397
posted
Yes, I read about this on other message boards, too. Some people, especially those with chemical sensitivities &/or CFS, are extremely sensitive to some components of the methylation protocol.
This genetic stuff can be very complicated. It's also not "proven" & not exact. It's really in it's experimental stages. It's hard to tell which is effecting what... I also read it can cause a release of mercury or probably other toxins or heavy metals.
Best to go very slowly & use binders.
Posts: 7772 | From Northeast, again... | Registered: Oct 2006
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annxyzz
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Member # 20404
posted
Sparkle , To me it makes sense to take the methylfolate if you have the gene that causes you to not convert folate . But it also makes sense to start with a low dose - maybe one tablet .
-------------------- annxyzz Posts: 1178 | From East Texas | Registered: May 2009
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desertwind
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Member # 25256
posted
I have a family hx of the c677t gene/MTHFR.
My aunt has the gene and suffers from chronic migraines and auras - as do I - as a result of high Homocysteine levels brought on by this condition.
I began supp.ing with Meythl Protect(xygomen) and found that my chronic flashing lights went away in less then an hour. However....
After taking a large dose I would get this weird chemical sensitivity like reaction. My head would get feeling buzzing and numb and alot of ringing in my ears AND I would feel over stimulated.
I take 1/4 of the recommended dose now and it helps with my migraine auras w/o the overstim. effects.
Thanks for posting the website....DW
It also has an ammino acid in that is typically given to people with high Homocystein levels
Posts: 1671 | From Tick Infested New Jersey | Registered: Apr 2010
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posted
Neither my husband or I had any issues with starting methylation with deplin or B12 and being over stimulated.
If anything, our thyroid is still low.
-------------------- Faithful
Just sharing my experience, I am not a doctor. Posts: 2682 | From Colorado | Registered: Oct 2009
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Razzle
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Member # 30398
posted
This is why it is critically important to know your other genomic variants in addition to MTHFR. MD's who only look at MTHFR are doing their patients a disservice.
Other methylation genomic variants determine how you go about treating MTHFR and getting methylation functional again.
If one cannot handle more methyl group can be answered by looking at other methylation variants.
Dr. Yasko says certain variants have to be dealt with first before MTHFR.
And one's COMT/VDR status also needs to be known, to determine whether one can handle the methyl from methyl-B12 or not.
This is very complex, and unfortunately most MD's don't understand that they need to learn about more than just MTHFR to be able to help those with methylation issues safely and correctly.
Yes, taking methyl-folate (5-MTHF) without the mineral support for CBS/SUOX, if one has CBS/SUOX variants, will likely cause one to feel more chemically sensitive.
Also, starting methylation mobilizes toxins the body was unable to detox before. This is uncomfortable, and a savvy physician will start people on very small amounts of 5-MTHF initially, and possibly also binders and other detox support stuff.
Dr. Yasko's protocol deals with all of this...I have yet to see anyone else's protocol that is capable of compensating adequately for all the issues of the complexities of methylation.
Just my humble opinion...
-------------------- -Razzle Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs. Posts: 4166 | From WA | Registered: Feb 2011
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annxyzz
Frequent Contributor (1K+ posts)
Member # 20404
posted
It is wonderful to hear how others respond . Thank you for sharing . I just ordered a methylfolate by Life Extension and plan to see if it has any positive effects, esp with mood .
I think if a person starts feeling really hyper , they might be wise to lower their thyroid meds and antidepressants a bit and see if they feel a little more normal .
-------------------- annxyzz Posts: 1178 | From East Texas | Registered: May 2009
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