nonna05
Frequent Contributor (1K+ posts)
Member # 33557
posted
the same or near to L-tryptophan??
Kavinance Pm was given to help sleep....Seemed to work a little ,but left me feeling kinda weird, not easy to explain, spacey dull .
When we have so many symptoms going on as it is ,it's hard to tell
I'd been having all those extra muscle /tingle/ prickly feeling's again ..
So I bought the Soothe and Relax from Researched Med...No noticing the 750mg of 5-HTP in it.
5-hydroxytrptophan in both, is it same basic thing as L-form?
Googled side effects of the l-form . It can create seritonin (sp?) syndrome as well as another issue,,,,,,,
It was supposed to soothe joint's and muscles, promote calm legs and mind and help with inflammation
Just wondering if it's causing or has caused issue's for anybody?
Could it interact or build up with any of the "usual supplements" mentioned/used with LD??
Posts: 2563 | From Denver,CO | Registered: Aug 2011
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
5HTP is used to make tryptophan then to serotonin which converts to melatonin = sleepy. Converts back to serotonin at daybreak.
L-tryptophan -> 5HTP -> serotonin <-> melatonin.
Excess 5-HTP, especially when administered with Vitamin B6, is thought to be metabolized and excreted. (Wikipedia). But you need to be able to process B6 to its active form i.e., PLP/P5P.
Thus avoiding "serotonin syndrome".
L-Tryptophan is the amino acid from which your body produces 5-HTP.
Prickling and tingling feeling = Peripheral neuropathy
Multiple nutrient deficiencies.
[ 05-24-2012, 11:09 AM: Message edited by: Marnie ]
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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Razzle
Frequent Contributor (1K+ posts)
Member # 30398
posted
5-HTP is tryptophan...just a different form of it that was developed when L-tryptophan was banned briefly (due to contaminated L-tryptophan supplements being sold in the 1980's/90's)...
-------------------- -Razzle Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs. Posts: 4166 | From WA | Registered: Feb 2011
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
5HTP = 5- *Hydroxy* tryptophan
There are L forms of tryptophan and D forms.
L tryptophan -> 5 HTP.
D tryptophan - the D-stereoisomer is occasionally found in naturally produced peptides (for example, the marine *venom* peptide contryphan).
Stereoisomers are isomeric molecules that have the
same molecular formula and sequence of bonded atoms (constitution),
but that differ only in the three-dimensional orientations of their atoms in space. Wikipedia.
Kind of amazing...same molecular formula, same sequence of bonded atoms, but with a different orientation - apparently makes a big difference.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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nonna05
Frequent Contributor (1K+ posts)
Member # 33557
posted
What would adverse side effects be... /feel like?
.Or would it take a ton of this stuff to do that... Can the L form have a negative reaction for some people pretty easily/quickly?
Not forgetting the other symptom I mentioned ..uneasy /dull/spacey/ Different than the LD brain fog
Posts: 2563 | From Denver,CO | Registered: Aug 2011
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
- You would never take "a ton" of anything
Very tiny amounts of 5-HTP really clobbered me for a day or two after a night-time dose. I tried several times and the same reaction.
Not everyone can take this. Your body is the best feedback: If you don't feel it helps, don't take it. Keep it that simple when it comes to support supplements. They are supposed to support you. If they do not, they are just not right for your body at that time.
In my experience with any and every supplement that is to help (in theory) with sleep, a "hang-over" effect for a day or two, even with low dose just seems to go along with that. So, I just don't take anything that has that kind of residual effect.
You can use this same template for just about anything you take. Google:
5-HTP, adverse+effects
and
5-HTP, reactions -
Posts: 48021 | From Tree House | Registered: Jul 2007
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
- Those with porphryia cannot tolerate tryptophan, by the way. That's likely why it's terrible for my body but I just happened to stumble upon that detail and wish I had known that before I even tried it.
As those with chronic stealth infections can have a "secondary porphyria" that is to be considered, too, whether the inability to process tryptophan is due to a genetic porphyria - or from an elevated porphyrin load for other reasons.
That may include those with HPU / KPU. Answers would lie in the links below.
Still, if 5-HTP does not seem to help, it does not help. Don't take it. Don't try to make it work if it does not.
Science 2 December 1983:_Vol. 222. no. 4627, pp. 1031-1033
DOI: 10.1126/science.6648517
Science, Vol 222, Issue 4627, 1031-1033 Copyright � 1983 by American Association for the Advancement of Science
L-tryptophan: a common denominator of biochemical and neurological events of acute hepatic porphyria?
DA Litman and MA Correia
Excerpt:
�� . . . These findings suggest that increased tryptophan and 5-hydroxytryptamine in the nervous system may be responsible for the neurologic dysfunctions observed in humans with acute attacks of hepatic porphyria. . . . ��
Biochem Pharmacol. 2008 Feb 1;75(3):704-12. Epub 2007 Oct 2.
Hepatic alteration of tryptophan metabolism in an acute porphyria model Its relation with gluconeogenic blockage. -
Posts: 48021 | From Tree House | Registered: Jul 2007
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posted
I had a terrible experience with 5htp. I took half of what I energetically tested for and did not feel normal until about 6 pm the next day -- It was not a good fit for me. Melatonin is much easier on me.
Posts: 859 | From Southeast | Registered: Mar 2011
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lymetwister
Frequent Contributor (1K+ posts)
Member # 19590
posted
Just to Clarify:
Tryptophan is 2 steps away from Serotonin.. Marnie has it backwards.
Trytophan --> 5-HTP --> Serotonin
If you have low Serotonin, this is the way to boost it. They say it's the feel good Neurotransmitter... Who knows ?
5-HTP is safe. They say not to mix with Antidepressants b/c of risk of Serotonin Syndrome.
Antidepressants don't make or raise Serotonin. Supposedly, they re-use what you already have. There is no scientific proof that this is what they actually do. Read any drug insert and it will clearly say "the exact mechanism is not fully understood".
Lastly, I have never heard of anyone getting Serotonin Syndrome from taking 5-HTP alone or even while taking an Antidepressant.
Personally, I think 5-HTP should be given to depressed individuals, but then again, your Psychiatrist would have to send you to a Vitamin store rather then a pharmacy :-)
Posts: 1227 | From District of Columbia | Registered: Mar 2009
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Had it right in my 2nd post and corrected the first.
L-tryptophan -> 5 HTP -> serotonin <-> melatonin.
The reversals are due to my German heritage. :-)
Speaking of melatonin...delta sleep (frequency) -> ATP up...a very good thing.
Hey, Rifers...paying attention?
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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lpkayak
Honored Contributor (10K+ posts)
Member # 5230
posted
hi guys...any of you 5-HTP experts around?
im confused
my bottle from NOW says it is for fibromyalgia
i have been dx for fibro b4 lyme and just think it is a garbage dx but my body is changing and along with charley horse type cramps and lower leg weakness to where i cant bear weight...and more perif neuropathy my "tender spots"-the ones they use to dx fibro are exceptioanallly sore
they hurt even with out pressure...i scream if my 10 lb dog walks across my lap...
i already take a lot of stuff and without fishoil and coq10 every 8 hrs i cant walk...
i have had insomnia all along but it is controlled with vistaril-that gives me rem sleep
i am so bad right now i dont want to take something that is going to knock me for a loop
will tHe 5-HTP help my pain=soreness in tender spots or only help me sleep
i have bad reactions to all antidepressants...anyone know the chancees htp will help and not hurt me? mine are 100mg. thanks
-------------------- Lyme? Its complicated. Educate yourself. Posts: 13712 | From new england | Registered: Feb 2004
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posted
I was told many years ago that 5-HTP was the "same" as trazodone.
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96222 | From Texas | Registered: Feb 2001
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lpkayak
Honored Contributor (10K+ posts)
Member # 5230
posted
and trazodone is just for sleep, right? maybe they figure fibro pain comes from not getting rem sleep so it will help. thx. still not sure if i should try it
-------------------- Lyme? Its complicated. Educate yourself. Posts: 13712 | From new england | Registered: Feb 2004
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Catgirl
Frequent Contributor (5K+ posts)
Member # 31149
posted
5 HTP did nothing for me (nor kavinace). My doc said it doesn't work for some people.
-------------------- --Keep an open mind about everything. Also, remember to visit ACTIVISM (we can change things together). Posts: 5418 | From earth | Registered: Mar 2011
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