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» LymeNet Flash » Questions and Discussion » Medical Questions » OspC Is Potent Plasminogen Receptor on Surface of Borrelia ...

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Author Topic: OspC Is Potent Plasminogen Receptor on Surface of Borrelia ...
wrotek
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http://brisson.bio.upenn.edu/files/Onder2012a.pdf
Posts: 635 | From Wroclaw, Poland | Registered: Mar 2004  |  IP: Logged | Report this post to a Moderator
GretaM
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Heavy reading, but fascinating. Thanks for posting [Smile]

small summary for those who aren't able to read the pdf.

Osp C (band 21kDa, according to the article), is a surface coating on BB that makes it disseminate quickly and more easily in it's vertebrate host.

The study also found that this coating can be 'turned on and off', depending on the needs and lifecycle of BB. (This tidbit of information made me especially angry... I hate BB and it's ability to morph).

Osp C starts in the midgut of the tick, and then accompanies BB into the host, for as long as BB needs it(mostly in early stages of transmission), thereby allowing BB to disseminate quickly into all tissues. (Plasminogen reception gives it an upper hand at evading host defenses and really needling it's way into all tissues).

Although the study also found that an anti OpsC prevented BB from morphing so effectively.

So that is some good news...Now where do I get my hands on some Anti OspC?

I'm sure I missed quite a bit in summarizing, but those were the bits that I could remember.

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poppy
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Great. We've been needing a science translator here. Thanks.
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payne
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thanks GretaM & wrotek")
we need a like button ("

--------------------
TULAREMIA/rabbit fever ?

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wrotek
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I wonder if binding plasminogen by borrelia will result in viscous blood
http://upload.wikimedia.org/wikipedia/commons/0/0e/Fibrinolysis.png

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Razzle
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Wouldn't anti-OspC only help if one had it in place at the time of exposure to Lyme?

I thought OspC disappeared after initial infection...?? [confused]

--------------------
-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

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GretaM
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Razzle-That was the gist I got from the pdf as well. That Osp C is key to quicker dissemination in BB. But there was something midway in the pdf that mentioned it turning it on and off, when it needed it. So I am not sure if it is something it uses when it needs to, or just in early days (hours), when it is trying to needle it's way into all the tissues.
Gosh I hate BB. Nasty, sneaky and built for survival. Argh!!

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wrotek
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quote:
Originally posted by Razzle:
Wouldn't anti-OspC only help if one had it in place at the time of exposure to Lyme?

I thought OspC disappeared after initial infection...?? [confused]

It is ospA (expressed in cold blooded ticks)that disappears, replaced with ospC in humans.
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oxygenbabe
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When I got lyme in 2000 I did research and spoke to a scientist who'd tried to get an OspC vaccine going. It would have been successful, but Yale with their OspA vaccine was competitive and killed it. An OspC vaccine makes more sense as that's what bb is expressing when it first gets in us.
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oxygenbabe
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When I got lyme in 2000 I did research and spoke to a scientist who'd tried to get an OspC vaccine going. It would have been successful, but Yale with their OspA vaccine was competitive and killed it. An OspC vaccine makes more sense as that's what bb is expressing when it first gets in us.
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wrotek
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quote:
Originally posted by oxygenbabe:
When I got lyme in 2000 I did research and spoke to a scientist who'd tried to get an OspC vaccine going. It would have been successful, but Yale with their OspA vaccine was competitive and killed it. An OspC vaccine makes more sense as that's what bb is expressing when it first gets in us.

Lymerix was anti OSPa and it was a disaster, it caused lyme symptoms in healthy individuals.
Interesting was that they removed the product from market under false pretense not being enough desire for vaccine.
What vaccine particularly are you talking about ?

Our body produces ospC antibodies which still cant get rid of infection

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poppy
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The new vaccine being trialed in Europe is also anti Osp-A, and will they have removed the elements that caused problems last time? I don't understand why they are going with Osp A instead of Osp C.
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