posted
I was diagnosed with MS and given interferon-B (Brand name is Betaseron), an immunosuppressant. I'm no longer on this and was undiagnosed with MS and then diagnosed with Lyme. I have neurological Lyme and am wondering if there is an antibiotic that crosses the blood brain barrier. I read somewhere that minocycline does but can anyone confirm this and is there any other? My LLND put me on minocycline for a short time and it caused horrible constant shocks in my eyes so I don't want to go on that again (but would if that's the only thing that crosses the barrier).
I am also wondering about using a drug called Bradykinin. It is used to modulate the permeability of the blood brain barrier. Thus I'm wondering if it could be used as a catalyst to deliver antibiotics across the BBB. It dilates the blood vessels, causing the blood vessel wall to weaken and lowers blood pressure. Or are there other pharmaceutical drugs or natural substances that would also do this? Is it a good or bad idea? My thinking is that it would help deliver antibiotics to the brain.
I'm going to be seeing my LLND in a couple days and will pose the question to him but I was wondering if anyone here has any thoughts about this or any experience with it.
-------------------- I'm not there yet but I'm closer than I was yesterday.---- Lyme Band 31,41,58. Being treated for Lyme and Bartonella. Posts: 149 | From Maine | Registered: Oct 2010
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kgg
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Member # 5867
posted
Minocycline does cross the blood brain barrier. I have heard of one LLMD who suggests starting it with one dose a week and ramping up. It can be very effective but hard to tolerate otherwise.
I hope someone comes along to give you a list, right now my brain has not woken up. But it is my understanding that some antibiotics that do not cross the blood brain barrier orally will intravenously.
I am not sure I would take Bradykinin. Many of us already have low blood pressure. And I am not sure causing blood vessel walls to weaken in the brain is a good thing. Just my opinion.
Best, Karen
Posts: 1687 | From Maine | Registered: Jun 2004
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lax mom
Frequent Contributor (1K+ posts)
Member # 38743
posted
Ditto the Mino. I'm taking a tiny dose, 50mg/day and it's enough to keep the brain fog at bay. Otherwise, I have trouble forming a sentence.
I started out taking 1 pill, every other day and worked up.
GretaM
Frequent Contributor (1K+ posts)
Member # 40917
posted
Minocycline and doxycycline cross the blood brain barrier.
Was on doxy, 200mg twice daily, for 2 months, helped with the head pressure and cognition, but had a sunlight reaction with it. Switched to 100 mg mino, twice per day... wOW! I am lucky enough to not have any dizzy side effects from it, and it really helps some of my neuro issues.
Posts: 4358 | From British Columbia, Canada | Registered: Jun 2013
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posted
My former llmd uses high dose amoxicillin - only crosses the bbb at high doses - he used a certain amox concentration in the blood to ensure optimal dosage. (weight dependent).
Posts: 348 | From NJ | Registered: Sep 2011
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posted
"I am also wondering about using a drug called Bradykinin. It is used to modulate the permeability of the blood brain barrier. Thus I'm wondering if it could be used as a catalyst to deliver antibiotics across the BBB. It dilates the blood vessels, causing the blood vessel wall to weaken and lowers blood pressure. Or are there other pharmaceutical drugs or natural substances that would also do this? Is it a good or bad idea? My thinking is that it would help deliver antibiotics to the brain. "
I think you would definitely want to avoid that!
Widening of the BBB is what causes MCS! MCS is a horrible, horrible ride with some people never being able to leave their house!
Just my 2¢ but I would never mess around with the BBB. It is built that way for a reason and removing that filter can have awful consequences.
Posts: 922 | From Philadelphia | Registered: Sep 2012
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GretaM
Frequent Contributor (1K+ posts)
Member # 40917
posted
My neuro issues are Short and long term memory loss (ongoing) Bell's palsy (resolved since doxycycline) Chattering teeth and facial muscles (resolved since mino) Head pressure (reduced by both) Head pain, migraine like (reduced by both) Speech difficulties- Caused by jaw not moving properly (resolved. with mino) Caused by inability of brain to find the right word (ongoing) Eye issues-looks like birds or flies, flying everywhere. (resolved with mino) Ears issues (fluid leaking from ears) (resolved doxy and mino) Partial paralysis on left side of body (somewhat better-left side still very weak) Coordination (ongoing) Depth perception (ongoing) Peripheral neuopathy (ongoing) RSDS-bee sting pains over body, intermittently(resolved with doxy and mino)
Posts: 4358 | From British Columbia, Canada | Registered: Jun 2013
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CherylSue
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Member # 13077
posted
I think Ceftin crosses BBB. Flagyl does not.
Posts: 1954 | From Illinois | Registered: Aug 2007
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It helped me loads with neuro issues. Brain fog lifted and memory returned!
I took 200-300 mg/day for awhile, now only when needed, some may need higher doses, but it has a burning side effect so be careful.
Shouldn't be taken at the same time as abx cause it's too tough on the liver, and it also has some antibiotic effects.
Posts: 1 | From Sweden | Registered: Jul 2013
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posted
Rocephin injections helped my neuro symptoms, but I could only handle low doses, so I was on it probably too long my LLMD thought.
-------------------- When you reach your "wits-end" remember this: "Peace I leave with you, my peace I give you. I do not give as the world gives. Do not let your hearts be troubled and do not be afraid." John 14:27 Posts: 397 | From Loudoun County Virginia | Registered: Mar 2007
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posted
Rocephin injections helped my neuro symptoms, but I could only handle low doses, so I was on it probably too long my LLMD thought.
-------------------- When you reach your "wits-end" remember this: "Peace I leave with you, my peace I give you. I do not give as the world gives. Do not let your hearts be troubled and do not be afraid." John 14:27 Posts: 397 | From Loudoun County Virginia | Registered: Mar 2007
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