Which brand of berberine are people buying for lyme?
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Marnie
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First link worked once again for me...
I hate/love computers!
But...if others have a problem, thanks for a second link.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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Marnie
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Glycox looks to be helpful.
Amazon.
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lpkayak
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So please translate-is berberine good or bad cuz i am just about to use it and i am already watching 3 cancers(for those who love me all are non-aggressive, slow growing,and only 5% chance they will kill me...but stilll...)
-------------------- Lyme? Its complicated. Educate yourself. Posts: 13712 | From new england | Registered: Feb 2004
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Marnie
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Berberine looks to be VERY helpful and works in MANY ways very similar to Minocycline.
But...it is likely berberine should NOT be taken in conjunction with some other drugs and possibly with some other OTC supplements.
It is IMPERATIVE you do not take berberine unless your doctor (and a pharmacist/pharmacists) agree there should not be any negative interaction based on their current knowledge.
Berberine inhibits a particular liver (primarily) enzyme that is needed to
metabolize many drugs.
Sometimes it is the "metabolite" of a drug that is actually the active/working component. The METABOLITE of Tamoxifen, for example, is the working component. It is imperative that the liver enzyme(s) that break down Tamoxifen are present
in the right amounts.
Now, genetically some persons either are slow, moderate, fast or ultrafast metabolizers using THAT liver enzyme - the one that berberine inhibits.
A (genetic) duplicate copy of THAT enzyme can -> death from a particular pain killer.
Children who have duplicate copies of that liver enzyme convert codeine -> morphine really really fast. They are ultrafast metabolizers.
Morphine is a respiratory DEPRESSANT.
This is rare, but in several instances codeine given to certain persons can cause death.
The knowledge of whether or not you are a slow metabolizer, moderate metabolizer, fast metabolizer or ultrafast metabolizer is the basis of genetic testing to decide the *dosage* you may need during cancer therapy...less or more.
For (tryptophan) reasons, the highest level of Prozac allowed appears to have protected my sis from "neuro" lyme. She began taking it a few years into lyme. However, it did NOT protect her from very very destructive arthritis (6 joints replaced so far).
That LIVER enzyme that berberine inhibits is involved in tryptophan metabolism too.
The LIVER enzyme I am talking about is CYP2D6.
According to Wikipedia:
"This enzyme *also* metabolizes several endogenous substances such as hydroxytryptamines and neurosteroids."
Hydroxytryptamine = 5HT = serotonin.
That enzyme appears to be in locations other than the liver too:
Many years ago I remember reading that Bb cannot grow without tryptophan. I am taking an educated guess, but it appears Bb needs a metabolite of tryptophan to survive. And we metabolize it for "him".
And antibodies to that enzyme can happen.
You can "Google" this: CYP2D6 Antibody
And just scroll down the list of links...until you reach "autoimmune"
There are many viruses that cross react and trigger TGFb (Transforming growth factor beta)...NOT good. Several viruses have similar/identical "antigens" = proteins = a certain chain of amino acids arranged in a particular sequence.
There are many cancers that berberine AND minocycline look to effect.
If you "Google" : berberine cancer OR minocycline cancer
You will begin to "see"....just skim the list of links.
We need cancer cells (DNA damaged - multiplying out of control) to die and the protein that is involved is p53. *Mutations of* that protein = problems. That protein PREVENTS cancer.
"Here, we show that TGFbeta-dependent cell migration, invasion and metastasis
are empowered by ***mutant-p53***
and opposed by p63."
One thing I would like to tell you is that berberine looks to impact stem cells too.
In the first paragraph in the above link, berberine is said to impact Topoisomerase:
Topoisomerases are *enzymes* that regulate the overwinding or underwinding of DNA.
The insertion of ***viral*** DNA into chromosomes and other forms of recombination can also require the action of topoisomerases.
Wikipedia.
Enzymes, genes, antigens, proteins = chains of amino acids in a particular sequence.
I think the p8 protein that Bb initially picks up in the tick's saliva is a retroviral protein called HTLV-1 which triggers a "remembrance" of our exposure to other viruses we have had in the past and upregulates TFGb.
This protein helps Bb evade an appropriate immune response...from the get-go.
I want to give you the KNOWLEDGE and information so YOU WITH YOUR DOCTOR'S HELP (and God's help!) can make the best decision in order for you to recover your health.
IMO, you must BELIEVE that God wants you to live a long and healthy life. It is God, You, and Your doctor working together that equals a healing "trinity" of sorts.
God bless.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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lpkayak
Honored Contributor (10K+ posts)
Member # 5230
posted
see...there is no way this can make sense to me
i wish i had your brain
"It is IMPERATIVE you do not take berberine unless your doctor (and a pharmacist/pharmacists) agree there should not be any negative interaction based on their current knowledge. "
none of my docs know anything about supps...or meds for that matter...they only know some about their favs i think
im not on tamox but now i am afraid to take the berberine-----i ordered it cuz others had good luck with it esp with reflux
oh well...who wants some berberine
-------------------- Lyme? Its complicated. Educate yourself. Posts: 13712 | From new england | Registered: Feb 2004
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Razzle
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lpkayak,
Ask your pharmacist if any of your meds require that liver enzyme CYP2D6. If none of your meds do, then you should be ok with the berberine. And a pharmacist SHOULD know the answer to this...
Marnie,
Thanks for sharing all this. So does this mean that Berberine could possibly also PREVENT infection with Lyme?
In other words, it seems that berberine counter-acts Bb's attempt at hijacking or hiding from the immune system, so does that mean that our immune system could then wipe out Bb from first exposure, IF we were to have sufficient Berberine in our body at the time of exposure?
-------------------- -Razzle Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs. Posts: 4166 | From WA | Registered: Feb 2011
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
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Prevent? Hum...
What if someone unknowingly has TWO copies of CYP2D6?
Dosage/timing then? (Berberine inhibits that enzyme.)
P.S. I have a close friend whose mother and brother both developed multiple myeloma which puts her at increased RISK.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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