posted
Borrelia miyamotoi sensu lato Seroreactivity and Seroprevalence in the Northeastern United States.
Here we go again. First, the CDC knows a B miyamotoi infection WILL NOT be detected by the standard b31 2 tiered test since its based on B31 antigens which are sufficiently dissimilar to Borrelia miyamotoi to not seroconvert ( i.e. create detectable antibodies). This is also true of the other pathogenic species seen such as B. americana, B. andersonii or B bissettii also seen in the US.
In California, the CDPH has been finding a 20% of burgdorferi nymphal tick infection rate for about 10 years. But CA is not supposed to be highly endemic? I think the word "Dufus" comes to mind here regarding ID doctors.
That would suggest in some areas in CA, 20% of the Lyme cases go undetected and probably go untreated until its too late.
Its pretty sad the CDC, IDSA and many infectious disease doctors know this and seemingly ignore it.
A poor but better than nothing GlpQ ELISA has been available in research labs for over 10 years to detect B miyamotoi. But your doctor cannot order it.
Just one more reason the 2 tiered test fails.And the list keeps growing and the emperor has no clothes.
quote: Abstract
Borrelia miyamotoi sensu lato, a relapsing fever Borrelia sp., is transmitted by the same ticks that transmit B. burgdorferi (the Lyme disease pathogen) and occurs in all Lyme disease-endemic areas of the United States. To determine the seroprevalence of IgG against B. miyamotoi sensu lato in the northeastern United States and assess whether serum from B. miyamotoi sensu lato-infected persons is reactive to B. burgdorferi antigens, we tested archived serum samples from area residents during 1991-2012. Of 639 samples from healthy persons, 25 were positive for B. miyamotoi sensu lato and 60 for B. burgdorferi. Samples from ≈10% of B. miyamotoi sensu lato-seropositive persons without a recent history of Lyme disease were seropositive for B. burgdorferi. Our results suggest that human B. miyamotoi sensu lato infection may be common in southern New England and that B. burgdorferi antibody testing is not an effective surrogate for detecting B. miyamotoi sensu lato infection.
Posts: 51 | From California | Registered: Aug 2013
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