Topic: Marnie....what is the relevance of minerals--
2roads
Frequent Contributor (1K+ posts)
Member # 4409
posted
...and why would ADH help Stage 4 nrem sleep?
Your findings years ago:
is your fasting blood glucose level? Some lyme patients develop diabetes. If it's okay, then bladder spasms are caused by a calcium influx into the cells (calcium causes muscle contractions, magnesium relaxes) = urgency.
The ususal treatment is pyridium which works, but IMO, doesn't address the underlying CAUSE.
They use one mineral to sub for another.
Re: pyridium, here's how it works:
Mechanism of action/Effect:
Exerts a ***topical analgesic or local anesthetic action on the urinary tract mucosa. The exact mechanism of action is unknown. {01}
1. Bilirubin. This test is based on the coupling of bilirubin with diazotized dichloroaniline in a strongly acid medium. After 30 seconds, the color ranges through various shades of tan. Only conjugated bilirubin enters the urine in significant amounts. Fresh urine should be used because hydrolysis converts conjugated bilirubin to the unconjugated form upon standing. The unconjugated bilirubin reacts poorly with the test reagents.
The test is somewhat less sensitive than the Ictotest but this causes few false-negatives. A positive result indicates elevated direct-acting serum bilirubin, seen in liver disease. Large doses of chlorpromazine may cause false-positive results, as with many drug metabolites which have a ***red color at low pHs (Pyridium and Serenium). http://www.dcss.cs.amedd.army.mil/field/DepmedsLabSOP/URINALSI/urinalys_toc.htm
So your urine takes on a different color and this breaks down to acetaminophen.
Anti-inflammatory, but so is Mg.
THANKS FOR YOUR HELP!!!
Posts: 2214 | From West Chester, PA | Registered: Aug 2003
| IP: Logged |
2roads
Frequent Contributor (1K+ posts)
Member # 4409
posted
This was what I meant to copy Marnie.....above not correct=
sleep apnea can also be assoc. with bedwetting and sleepwalking (problem with stage 4 of NREM - non rapid eye movement sleep). This is when the brain waves are really slow and before they speed up and REM - rapid eye movement - kicks in. Imipramine or ADH (antidiuretic *HORMONE) are sometimes prescribed. See also PMID:15565533 - sleep apnea, restless legs and what was Rx'd. The brain puts out extra amts. of ADH (also called vasopressin) at night. This causes the kidneys to reabsorb water, so they produce small volumes of concentrated urine.
As we age, the circadian rhythms that control *SALT and water excretion (among other things) begin to change. Many older people revert to the juvenile pattern of steady urine production around the clock.
Children on Ritalin for ADHD also have improvement in bed wetting problems.
Do you see the connections between the minerals...Ca, Mg, Na?
Mg is needed to make all proteins...and hormones are proteins. It is a muscle relaxant. Mg prevents calcium influx. Looks like if Mg is low, sodium channels open up too (hence Na channel blockers to stop seizures).
Re: bab
Posts: 2214 | From West Chester, PA | Registered: Aug 2003
| IP: Logged |
2roads
Frequent Contributor (1K+ posts)
Member # 4409
posted
Marnie,
r u saying that balanced minerals, balance salt and water excretion which balances ADH, which balances sleep?
I've read that deep sleep promotes increase into ADH, not the other way around.....but maybe I don't get it.
thanks
Posts: 2214 | From West Chester, PA | Registered: Aug 2003
| IP: Logged |
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
REM...acetylcholine
Lyme patient I know has no REM sleep - lab tested
NREM...melatonin..which comes from serotonin which comes from tryptophan...but MS, HIV,Lyme all look to trigger the kynurenine pathway of *tryptophan metabolism*...throwing off a balance.
Primers.
You know that Ritalin contains a "methyl" group, right? When my son's Ritalin STOPPED working (years ago), his blood level indicated his folic acid level was extremely low (needed Rx doses to restore). Every day at 4pm he "crashed"...back to hyper as the Ritalin wore off. Possible link to cortisol levels.
Before you jump into going along with Ritalin suggestion (we've been there), consider trying P5P by Now...their formulation also contains B2 (which helps us absorb B6) and Mg. My son takes 50mg (that is very low dose) daily.
Homocysteine (comes from methionine in protein) isn't exactly a good thing...lowered via "remethylation" or transsulfuration pathway. Both are supposed to work, but in a jam, it appears (my son) uses the "transsulfuration" pathway primarily i.e., he doesn't "recycle" homocysteine back to methionine. Needless to say, he craves protein.
If any of the nutrients or enzymes along the pathway are disrupted, homocysteine can go up and it will impact the mitochondria too...absolutely.
He NEEDS eggs over easy (!) for the MANY nutrients in them.
Homocysteine is an "exciting" neurotransmitter and impacts the NMDA (glutamate - accelerator) receptors! Glutamate -> GABA / accelerator to brake requires 2 GAD enzymes which need B6.
I've linked pictures of the methylation pathway, to help you to see.
You will see where MTHFR (20% of the population have problems)fits into the picture and other nutrients and enzymes can also fit into the picture. Look up the enzymes one at a time. Example: BHMT is zinc dependent.
No sleep = hospitalized with mania in bipolar patients...in about 3 days. Genetic triggers: MTHFR, high homocysteine (CBS problem), Wilson's disease, etc....OR infection...
Niacinamide also helps us to sleep...it is the no flush version of B3 - niacin.
Many psych drugs for depression deplete melatonin.
Watch out that they are not masking an underlying D3 deficiency triggering the depression.
In boys (esp.) homocysteine levels go up at puberty - documented. That is when my son had his first seizure.
It took us a long time to realize P5P can stop his seizures.
B6 deficiency also linked to learning disabilities.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
| IP: Logged |
2roads
Frequent Contributor (1K+ posts)
Member # 4409
posted
thanks Marnie.
Was there a link between ADH and sleep disorder that you found.
I'm sorry if I'm missing it. It's been a lot of tailspinning for me.
hugs
Posts: 2214 | From West Chester, PA | Registered: Aug 2003
| IP: Logged |
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
It sure as heck appears he may be suffering with "alpha wave intrusion" during delta sleep. Not uncommon...anxiety, stress and PTSD can trigger it too.
The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:
The
Lyme Disease Network of New Jersey 907 Pebble Creek Court,
Pennington,
NJ08534USA http://www.lymenet.org/
UBBFriend: Email this page to someone!
Printer-friendly view of this topic