susank
Frequent Contributor (1K+ posts)
Member # 22150
posted
I am scheduled to have this test.
I am confused re:
Substrates, inhibitors and inducers.
The inhibitors and inducers only act on the substrates?
Hypothetically - if one does not take one of the listed/known substrates - then no concern?
Do the inducers and inhibitors act on each other? Or only on substrates?
Antibiotics? Foods? Essential oils?
Which test is better - saliva swab or blood?
FWIW I had a swabbing done for Primex lab. Not enough sample was submitted - so test cancelled. Primex not very helpful - but my doctor says they have the best test.
Thanks any help.
-------------------- Pos.Bb culture 2012 Labcorp - no bands ever Igenex - Neg. 4 times With overall bands: IGM 18,28,41,66 IND: 23-25,34,39 IGG 41,58 IND: 39 Bart H IGG 40 Posts: 1613 | From Texas | Registered: Aug 2009
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
- I'm not familiar with that lab but I don't see how such an abbreviated test can work. I'll have to look later.
That lab may be good for basic readings. My detail may be dated a bit but just be careful the tests are not too simplistic. A (mouth?) swab just won't tell you much. Blood, alone, will be limited but a start.
Are you talking about porphyria testing? If so, see the organizations here for the most up to date details.
Typically, required for testing will be ALL three (at least back when I had the testing done) -- it's icky but they need all this to assess for ALL the different kinds of porphyria. there are at least 11 kinds.
1. blood - and kept in dark during the draw -- aluminum foil covers the vial.
2. 24 hour urine collection - in dim light, transferred to very dark plastic jar. Kept in Fridge.
3. 24 hour stool collection - and in dim light and put into dark plastic container in as dim a light as possible during collection. Keep in freezer.
Back with a link for you. I lost it. search the American Porphryia Association.
But also know that with lyme, and MCS, a "secondary" porphyria can be a major player. Most porphyria experts do not acknowledge that.
any drug or chemical can trigger a porphyria episode. Some are worse than others an are on some lists. but absence from the list is no guarantee. -
Posts: 48021 | From Tree House | Registered: Jul 2007
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
- I don't have time to sort it out now but the Porphryia thread is in this set:
LIVER & KIDNEY SUPPORT & and several HERXHEIMER support links, too. -
Posts: 48021 | From Tree House | Registered: Jul 2007
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susank
Frequent Contributor (1K+ posts)
Member # 22150
posted
No - don't think is Porph test.
I think the CYP 450 is a pharmagenomic test - to see if a person has defective metabolism pathways?
ie careful when drinking grapefruit juice because of its effects on some drugs.
-------------------- Pos.Bb culture 2012 Labcorp - no bands ever Igenex - Neg. 4 times With overall bands: IGM 18,28,41,66 IND: 23-25,34,39 IGG 41,58 IND: 39 Bart H IGG 40 Posts: 1613 | From Texas | Registered: Aug 2009
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
- That is what porphyria is, though - the very definition of it: metabolic pathway problems processing Cytochrome P-450 "agents" - defective genes can cause this --
or it can be acquired from infection / liver damage.
Now, if they are testing certain drugs, not you, they have different methods.
??? Are they trying to test your GENES, though? If so, that would be easier and I can see that an easier test would be nice. -
Posts: 48021 | From Tree House | Registered: Jul 2007
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susank
Frequent Contributor (1K+ posts)
Member # 22150
Seems like I have seen other lists that include foods like brocolli and brussel sprouts.
Also have read where some essential oils are proccessed through some CYP450 pathways.
-------------------- Pos.Bb culture 2012 Labcorp - no bands ever Igenex - Neg. 4 times With overall bands: IGM 18,28,41,66 IND: 23-25,34,39 IGG 41,58 IND: 39 Bart H IGG 40 Posts: 1613 | From Texas | Registered: Aug 2009
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
- I have porphyria and most essential oils - in the air - really knock me out. (Lavender is the worst. Lemon is okay.)
I do find with broccoli and brussel sprouts, the are good for me. But, if you ask what foods will affect certain medicines, that's a different matter.
about "Substrates, inhibitors and inducers?" is a puzzle I've never quite understood.
I don't have time to look over that now but will in the next day or so. Hopefully, others are more familiar with that site, test.
Last I checked the genetic tests for Porphyria were not yet good enough. That was about a year ago. Sorry I can't spend time on this now to help better.
So much about this, though, can be just how you feel with any Rx, food - or combinations. Your body can tell you. There are certain Rx that are definitely on the C-P450 lists, though. I always did worse with those and it was good to learn why that was. -
Posts: 48021 | From Tree House | Registered: Jul 2007
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Razzle
Frequent Contributor (1K+ posts)
Member # 30398
posted
Substrates = what the enzyme acts on.
Inducers = stuff that increases the activity of the enzyme, thus increasing the rate at which a substrate is processed by the enzyme.
Inhibitors = stuff that decreases the activity of the enzyme, thus decreasing the rate at which a substrate is processed by the enzyme.
The CYP-450 test is a gene test. It is not looking for porphyria.
-------------------- -Razzle Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs. Posts: 4166 | From WA | Registered: Feb 2011
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