I'm wondering if there is any data regarding the effectiveness of Doxycycline for chronic Lyme?
Thank you!
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Keebler
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- Do you have an ILADS educated lyme literate doctor?
Lyme requires a combination approach with frequent rotations, whether with Rx, herbal support or incorporating various modalities.
And there are other infections that often go with lyme for which antibiotics just don't work.
It's very complex. Bottom line, though, no single antibiotic is appropriate treatment, especially in the chronic stage.
Doxycycline (or other antibiotics), alone, can make lyme even more chronic as it forces spirochetes to go into the cystic form and antibiotics don't work with that form.
If this is a matter of it's all you've got, there are other ways to approach this. -
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Keebler
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. . . A common conception is that Borrelia bacteria in human blood have a spiral or zig-zag shape.
However, the absence of such shapes in the blood does not exclude the presence of the bacteria.
The researchers see examples of the bacteria straightening out after 24 hours, or they may exist as tiny structures with simple geometrical shapes, or form round structures (the aforementioned cyst stage).
"Our experiments show that virtually all the bacteria change into the cystic form in the course of just one hour.
*** We can then expose them to almost any ANTIBIOTIC medication, but nothing destroy these [cyst form] *** . . . . [emphasis is that of poster]
. . . this is actually staggeringly complex. I have pointed out a problem that nobody has taken very seriously, in my view - at least not many doctors", says Laane. -
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Keebler
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Everything you thought you knew about cyst busters is wrong
Excerpt:
. . . Eva Sapi's recent research calls into question everything we thought we knew about Lyme "cysts." In fact it destroys the old thinking.
We have heard about cell wall antibiotics, intracellular antibiotics and cyst-busters. Think again.
She investigated the effect of various antibiotics on Lyme spirochetes and round body forms - also know as cystic forms.
Doxycycline worked according to plan. Doxy inhibits protein synthesis - it kills bacteria, including Lyme, by action within the cytoplasm, inhibiting the manufacture of proteins required for the bacteria's survival. Doxy and others are commonly referred to as intracellular antibiotics.
Spirochete loads decreased by about 90%
while cyst levels increased by 200% - just as expected. . . . -
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Keebler
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WHY you need an ILADS "educated" or "minded" Lyme Literate doctor (whether MD or ND, or both) - starting with assessment / evaluation.
And, not to worry that all is impossible if you can't obtain a LL doctor. In the "How to find a LL ND" see the various BOOKS & the RIFE machine links, etc. While not necessarily ideal, there are some things that we can still do for ourselves. -
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Keebler
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- BIOFILM is another whole matter regarding the ability of antimicrobials to penetrate. -
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Keebler
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Keebler
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posted
- The above articles, I hope, will serve as medical science explanations as to why it's not a good choice - nor is any single antibiotic, alone, a good choice for treatment.
So, why would there be a bunch of folks put on that for a study just to gather more data when it's shown to not be a good choice, alone.
As the questions is qualified by "chronic lyme" those doctors who really know & understand chronic lyme would not approach treatment in such a way as to suggest just a single antibiotic, it would be unethical, whether in a study or in a single patient.
It's also a terrible choice, alone, for anyone with lyme as lyme usually involves OTHER infections, many of which are not helped by any antibiotic. So, again, sole abx treatment would be unethical.
Add to that the experience of so many with chronic lyme. Many, if not most, while likely diagnosed late, when finally got some kind of treatment with a typical doctor, also likely were just allowed a single antibiotic, not a combination protocol.
You may see some articles by IDSA members that suggest a single dose of doxycycline - or a short course might be effective. But many who do not recover with this are discounted by ongoing symptoms that the IDSA doctors will then claim are "just the aches and pains of daily living." -
[ 08-31-2017, 02:36 PM: Message edited by: Keebler ]
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Keebler
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- For perspective. While you did not ask about duration of treatment since most typical doctors are woefully, shamefully unaware that short treatment courses often result in failure,
this first one is just about lyme, though, not so much the full plate with other coinfections:
Controversy continues to fuel the "Lyme War" - Clinical Advisor, 2007
[section] Treatment dilemmas . . .
. . . Borrelia burgdorferi has an in vitro replication cycle of about seven days, one of the longest of any known bacteria. Antibiotics are most effective during bacterial replication, so the more cycles during a treatment, the better.
Since the life cycle of Streptococcus pyogenes (the bacterium that causes strep throat) is about eight hours, antibiotic treatment for a standard 10 days would cover 30 life cycles.
To treat Lyme disease for a comparable number of life cycles, treatment would need to last 30 weeks. . . .
Two Standards of Care Revisited: Should Lyme Patients Have A Choice?
By Lorraine Johnson, JD, MBA - 7th January 2015 -
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Keebler
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- In addition to the ILADS link previous posted, this is an excellent template of sorts to consider. Even if other methods are used, the point is that direct / assertive attention to infection must be designed specifically to that microbe
while also supporting the body with key nutrients & methods.
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