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» LymeNet Flash » Questions and Discussion » Medical Questions » Does amoxicillin work even if short half life means there isn't any in body at night?

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Author Topic: Does amoxicillin work even if short half life means there isn't any in body at night?
lymeonade2015
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The half-life of amoxicillin is about 1 hour. I'm currently taking it 3 times a day. This means that the drug is not in me for almost the entire night, and portions of the day. Is this okay? Can it kill lyme spirochetes even if there isn't a constant body level of the drug for more than an hour or two?

Thanks,

Posts: 69 | From NYC | Registered: Apr 2015  |  IP: Logged | Report this post to a Moderator
TF
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Because of its short half-life, amoxi must be taken with probenecid. See Burrascano:

"Amoxicillin- Adults: 1g q8h plus probenecid 500mg q8h; doses up to 6 grams daily are often needed" (page 18)


It is NOT OK to take it without the probenecid. The probenecid keeps the amoxi from being filtered out of the blood so quickly.

Even my lousy lyme doctor had me on probenecid when he gave me amoxi. I sure hope you are on it also.

Amoxi cannot kill anything when the dosage goes low. That is why the dosage has to be so high.

Burrascano has an asterisk in front of amoxi and a number of other meds. This is the meaning of the asterisk:

"Always check blood levels when using agents marked with an *, and adjust dose to achieve a peak level above ten and a trough greater than three. Because of this, the doses listed below may have to be raised."


When I was on amoxi, I took 1,500 mg every 8 hours. It did the trick.

I hope you can see the advantage of studying the Burrascano Guidelines. It gives you a way to know if you are receiving good lyme treatment or not.

Posts: 9931 | From Maryland | Registered: Dec 2007  |  IP: Logged | Report this post to a Moderator
sixgoofykids
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My LLMD gave me Probenecid with amoxy.

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Posts: 13449 | From Ohio | Registered: Feb 2007  |  IP: Logged | Report this post to a Moderator
   

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