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» LymeNet Flash » Questions and Discussion » Medical Questions » Can not sleep but very tired

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Author Topic: Can not sleep but very tired
Frequent Contributor (1K+ posts)
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So I went from sleeping tons to NOT BEING ABLE TO SLEEP MUCH. I'm having tons of difficulty falling asleep, and I wake up constantly throughout the night.

I had a sleep study several months ago and am using a CPAP again.

Can IV rocephin cause sleeplessness? I've been on it for about a month now. The only other change is that my doctor has me taking lamictal at night instead of in the morning.


Just sharing my experiences, opinions, and what I've read and learned. Not medical advice.

Posts: 1431 | From USA | Registered: Mar 2015  |  IP: Logged | Report this post to a Moderator
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When doing rocephin the herx is what keeps me from resting , .o thought it was the zith or adrenal melatonin high dose kinda helps ,but phenibut seems to do it ...

not sure on the lamctal ...maybe others can help...


Posts: 1538 | From southwest | Registered: Dec 2015  |  IP: Logged | Report this post to a Moderator
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sorry I have no idea. hope you find relief

Be thankful in all things- even difficult times and sickness and trials - because there is something GOOD to be seen

Posts: 3394 | From Eastern USA | Registered: Jul 2013  |  IP: Logged | Report this post to a Moderator
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Night time cortisol is likely up. It is anti-inflammatory - obviously.

It is supposed to be down during the night.

It is highest at 8am and then goes down gradually throughout the day

under normal circumstances.

Cortisol levels take a secondary dip around 4-5pm.

You can have a fasting 8am blood test to determine your cortisol level.

When cortisol is broken down, it will show up in a urine spec. as 17Hydroxycorticosteroid.

If your cortisol is low...reservatrol can raise the cortisol level.

More likely it will be high.

You can order medical testing in most states over the internet and self-pay for the testing. Lab Corp runs the tests:

Many doctors don't like that...patients ordering their own testing even if the patient is self-paying (insurance does not cover).

When there is a LOT of inflammation going on due to infections or toxins (inflammation is part of healing) the body goes into a cortisol "sparing" mode

to balance inflammation + anti-inflammation.

Trying to maintain some degree of homeostasis. Follow?

There are some things that can lower cortisol, but keep in mind, it is up FOR A REASON, but a cortisol elevation when trying to sleep = problem.

To lower cortisol:

If you can get inflammation down (lower aldosterone), cortisol might also then resume it's normal "rhythm".

Phenobarbital used to be given to infants who had their days and nights mixed up (me). I was awake all night and asleep all day. My mom didn't like that!

Phenobarb. induces the liver enzyme CYP3A4 whereas IL-6 (immune interleukin 6) is inhibiting CYP3A4.

Antioxidant help:

Sublingual Glutathione is available from Source Naturals. Glutathione is our #1 antioxidant. It is normally destroyed by stomach acids, so the sublingual form (dissolved under the tongue) is needed.

A lot of NAC (N acetylcysteine) can help raise glutathione levels. I have been taking 1800 mg daily.

The key to measuring how much inflammation is happening is CRP = C reactive protein (made in the liver in response to a lot of inflammation). Blood test. Not expensive. Cardiologists look at that level. High is not good.

Look very closely at a blood pressure lowering drug called Telmisartan. ;-)

It is an angiotensin II inhibitor.

Talking thru this...inflammation of blood vessels -> reduced blood flow = circulation down ("yang" in Chinese terms) which signals the liver to produce angiotensin I which signals the lungs to produce angiotensin II which signals the adrenals to increase aldosterone which causes inflammation to go up...

Once again...a delicate balance of inflammatory cytokines (aldosterone can trigger) and anti-inflammatory (cortisol).

Inflammation is necessary and is part of healing, but when it is ONGOING = major problem.

Infected DNA damaged cells have to make a choice...damage too bad for repair = schedule cell death. Not too fast, not too many cells knocked off too quickly. The body can only clear debris just so fast. (Think about the reaction to chemotherapy as a lot of cancer cells are destroyed.)

If the cellular DNA damage is not too bad and repair is possible = other "helpers" arrive.

Normally our cells have a certain "recycle" time. Intracellular infections/toxins can alter the cell death time.

Tamoxifen is a toxin. Does that surprise you?

Premature aging happens under stress. Look at our President's hair...H2O2 causes the greying - oxidative stress = DNA damage = aging.

Two very major problems are happening - too much oxidative stress (too many free radicals) and way too much inflammation.

Neither of which is working to destroy Bb and company.

Personally, I'd be doing HBOT daily AND taking Pycnogenol (1 mg per pound of body weight) per day. If you weigh 150 pounds, you would take 150mg of Pycnogenol.

This was told to my husband by a doctor (who was looking at a model home) many years ago so I feel this suggestion is okay to repeat it to you all.

I couldn't convince my sis to come to Florida to do HBOT here in 2001.

At that time we also had a powerful Rife unit available and treatments = 5 for $100.

"One Speed Greg" (use to be on lymenet) did the Rife therapy and also paid a lot of attention to eating VERY healthy. When feeling better, he was able to resume exercise (rides a bike).

He recovered.

Recovery IS possible. Don't be afraid to think/try treatments that are "out of the box".

Healing IS possible. This disease can be halted and damage can be reversed, but it does take TIME.

Posts: 9402 | From Sunshine State | Registered: Mar 2001  |  IP: Logged | Report this post to a Moderator
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I looked at 2 websites and both said Lamictal can cause insomnia:

Common Lamictal side effects may include:

•headache, dizziness;

•blurred vision, double vision;

•tremor, loss of coordination;

•dry mouth, nausea, vomiting, stomach pain, diarrhea;

•fever, sore throat, runny nose;

•drowsiness, tired feeling;

•back pain; or

•sleep problems (insomnia).

Common side effects of Lamictal may include: dizziness, tremors, sleepiness, loss of coordination, headache, double vision, blurred vision, nausea, vomiting, stomach pain, dry mouth, changes in menstrual periods, back pain, sore throat, runny nose, or sleep problems (insomnia).

Posts: 9931 | From Maryland | Registered: Dec 2007  |  IP: Logged | Report this post to a Moderator
LymeNet Contributor
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I use liquid Malatonin and when my body stops responding to that, I switch over to taking a Valerian capsule an hour before bed.
Posts: 653 | From Northern Virginia | Registered: Oct 2014  |  IP: Logged | Report this post to a Moderator
Honored Contributor (10K+ posts)
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Congratulations! I was able to understand what you posted for the first time in a long time. And it isn't because I am any smarter- that's for sure.

It is because you are able to bring it to our level better. That is so nice.

Thank you! Thank you! Thank you!


Posts: 20325 | From The Moon | Registered: Jun 2004  |  IP: Logged | Report this post to a Moderator

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