LymeNet Flash: MTRR homozygous

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»	LymeNet Flash » Questions and Discussion » Medical Questions » MTRR homozygous

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Topic: MTRR homozygous

WPinVA
Frequent Contributor (1K+ posts)
Member # 33581

posted

Anyone else homozygous for MTRR? ( I am specifically MTRR A664A). From what I am reading, it complicates things --

http://www.mthfrsupport.com.au/mtr-mtrr/

so I would welcome advice from anyone who has already figured this out. thanks!

Posts: 1737 | From Virginia | Registered: Aug 2011 | IP: Logged |

sillia
LymeNet Contributor
Member # 23994

posted

I think that link describes pretty well how complicated this is -- over methylating as bad as under methylating.

I am hetero for 3 MTRR's. According to my notes this may tend to deplete my B12. I'm also homozygous for MTHFR and have the dreaded CBS +/+. I barely understand any of this, but it does seem like this is one of the factors explaining why I can't get well.

I am just tunneling along, working on this piece by piece as well as I can. I think it is part of my puzzle.

Posts: 261 | From Nebraska | Registered: Jan 2010 | IP: Logged |

GretaM
Frequent Contributor (1K+ posts)
Member # 40917

posted

Hey WP,

I am homozygous for the MTRR mutation also. Aren't we lucky?

I take 15 mg (milligrams, not a typo) of methylcobalamin B12 daily. One tablet under the tongue every morning.

I had to work up to the 15mg.

So far have not noticed an impact in feeling better.

Regards,
Greta

Posts: 4358 | From British Columbia, Canada | Registered: Jun 2013 | IP: Logged |

WPinVA
Frequent Contributor (1K+ posts)
Member # 33581

posted

Thanks Greta! From what I'm reading, it seems better to start the B12 before the methylfolate.

So are you just taking B12?

Right now I'm taking a multiproduct with both methyl B12 and the folate. But I'm thinking I need to stop that and just do the B12 for a while....

Posts: 1737 | From Virginia | Registered: Aug 2011 | IP: Logged |

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