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» LymeNet Flash » Questions and Discussion » Medical Questions » Dr K's protocol's high dose ivermectin

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Author Topic: Dr K's protocol's high dose ivermectin
DawnWhite
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Some published versions of Dr K's protocol suggest 12mg ivermectin 4x daily, or 48mg daily for two weeks. This is a very high dose of ivermectin but appears to be safe based on other studies.

Has anyone tried that high of a ivermectin cycle?
The protocol is linked below.

Klinghardt Autism Protocols 2018 - Klinghardt Institute

**name of LLMD edited per LN rules**

[ 11-30-2019, 02:39 PM: Message edited by: Lymetoo ]

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Lymetoo
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That's REALLY high.

--------------------
--Lymetutu--
Opinions, not medical advice!

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Broxin
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DawnWhite, is this protocols main focus the killing of Borellia?
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Keebler
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If memory serves, I think the inclusion of ivermectin in his protocol is to address worms and those kind of critters that can also come from a tick's stomach.

Again, memory sort of vague here but I think I recall hearing / reading that other LLMDs also say this, or some other way, of address worm-ish critters could be key to the overall treatment being effective - or not - against lyme & other infections as they can be harbored in the worm-ish critters.

I'm vague with names as there are various names for worm-y things at various stages of their life cycle.

And, other parasites, whatever the form, that can travel form tick also pose other health challenges even were they not to travel with lyme & co. But when they do travel with lyme, lyme can become more stealth like and harder hitting when it strikes out.

If I recall / interpret correctly. You might want to explore this in his work and also in other LLMD's ILADS conference presentations over the years / their articles.
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DawnWhite
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quote:
Originally posted by Broxin:
DawnWhite, is this protocols main focus the killing of Borellia?

It seems ivermectin has multiple effects (antiparasite, antiworm, antimalaria, etc). I was struck by the dose recommended but have double checked and it appears to be correct.

Dr. William Wong has great things to say about ivermectin:

https://www.youtube.com/watch?v=ID1GmoyQU8A

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Keebler
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Considerations to consider.

Just a start to more research, to learn more about what to be mindful of, regarding dose, and the effect on liver / kidneys in some people -- at Wikipedia. It might be helpful to ask one's LLMD or LL ND which key liver / kidney supports should first be on board for the best result.

https://en.wikipedia.org/wiki/Ivermectin#Contraindications

Ivermectin

Excerpts:

. . . . . . Contraindications

Ivermectin is contraindicated in children under the age of five or those who weigh less than 15 kilograms (33 pounds)[34],

women who are breastfeeding,

and individuals with liver or kidney disease.[48]

Adverse effects [& drug interactions]

The main concern is neurotoxicity, which in most mammalian species may manifest as central nervous system depression, and consequent ataxia, as might be expected from potentiation of inhibitory GABA-ergic synapses.

Dogs with defects in the P-glycoprotein gene (MDR1), often collie-like herding dogs, can be severely poisoned by ivermectin.

The mnemonic "white feet, don't treat" refers to Scotch collies that are vulnerable to ivermectin.[49]

Since drugs that inhibit the enzyme CYP3A4 often also inhibit P-glycoprotein transport, the risk of increased absorption past the blood-brain barrier exists when ivermectin is administered along with other CYP3A4 inhibitors.

These drugs include statins, HIV protease inhibitors, many calcium channel blockers, lidocaine, the benzodiazepines, and glucocorticoids such as dexamethasone.[50] . . .
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DawnWhite
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Thanks for the detailed response Keebler. I've read a great deal of literature on Ivermectin and although like everything there are conflicting findings, it seems in general to be quite safe.


quote:
Ivermectin was generally well tolerated, with no indication of associated CNS toxicity for doses up to 10 times the highest FDA-approved dose of 200 microg/kg.
Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects.
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Keebler
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Dawn, Thanks. That's a good article. Here's another to complement that. It really sounds promising for helping curb malaria transmission in some very malaria-prone locations.

(Although considering possible drug interactions would still be a question for each person as might an individual's liver / kidney health starting out - for any special supports that may be required. LLMDs and LL NDs are usually very good with that matter.)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459982/

Efficacy and risk of harms of repeat ivermectin mass drug administrations for control of malaria (RIMDAMAL): a cluster-randomised trial

Lancet. 2019 Apr 13; 393(10180): 1517–1526.

Excerpt: . . . Interpretation

Frequently repeated mass administrations of ivermectin during the malaria transmission season

can reduce malaria episodes among children without significantly increasing harms in the populace.. . .
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Keebler
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This reminded me of an article I stumbled upon last week. Deliciously interesting.

https://www.cnn.com/2019/11/18/health/malaria-fighting-soup-wellness/index.html

A school soup project, healing soups, some even found to help against malaria. CNN Nov. 18, 2019

in the BMJ (British Medical Journal), they say. Recipes?
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Broxin
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quote:
Originally posted by Keebler:
-
This reminded me of an article I stumbled upon last week. Deliciously interesting.

https://www.cnn.com/2019/11/18/health/malaria-fighting-soup-wellness/index.html

A school soup project, healing soups, some even found to help against malaria. CNN Nov. 18, 2019

in the BMJ (British Medical Journal), they say. Recipes?
-

Nice find

Here is the whole study
https://adc.bmj.com/content/104/12/1138

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