LymeNet Home LymeNet Home Page LymeNet Flash Discussion LymeNet Support Group Database LymeNet Literature Library LymeNet Legal Resources LymeNet Medical & Scientific Abstract Database LymeNet Newsletter Home Page LymeNet Recommended Books LymeNet Tick Pictures Search The LymeNet Site LymeNet Links LymeNet Frequently Asked Questions About The Lyme Disease Network LymeNet Menu

LymeNet on Facebook

LymeNet on Twitter




The Lyme Disease Network receives a commission from Amazon.com for each purchase originating from this site.

When purchasing from Amazon.com, please
click here first.

Thank you.

LymeNet Flash Discussion
Dedicated to the Bachmann Family

LymeNet needs your help:
LymeNet 2020 fund drive


The Lyme Disease Network is a non-profit organization funded by individual donations.

LymeNet Flash Post New Topic  New Poll  Post A Reply
my profile | directory login | register | search | faq | forum home

  next oldest topic   next newest topic
» LymeNet Flash » Questions and Discussion » Medical Questions » Western Blot IGM/IGG Question

 - UBBFriend: Email this page to someone!    
Author Topic: Western Blot IGM/IGG Question
francot
Junior Member
Member # 49447

Icon 1 posted      Profile for francot     Send New Private Message       Edit/Delete Post   Reply With Quote 
I tested positive to IGM 39 on Western Blot through Lab Corp.

I realize that I need better testing and I am in the process of finding a LLMD.

From doing research I understand that IGM means that I have an active infection, and I am trying to remember when I was bitten by a tick?

How long does it take from being bitten to becoming IGM positive?

Assuming I did nothing and did not get treated, how long does it take to go from IGM positive to IGG positive?

If I did not get treated would I always stay IGM positive or would I move to IGG(past exposure)?

I guess what I am wondering is could I have this Lyme infection for years, and be IGM positive because I never received any treatment.

Posts: 3 | From PA | Registered: Dec 2016  |  IP: Logged | Report this post to a Moderator
TF
Frequent Contributor (5K+ posts)
Member # 14183

Icon 1 posted      Profile for TF     Send New Private Message       Edit/Delete Post   Reply With Quote 
Yes, you could have had this infection for years. Lyme does not "follow the rules" regarding IgG and IgM.

So, the more you learn about lyme and it symptoms, often the further back in your life you can detect symptoms of lyme. I eventually concluded that I had likely had lyme for 10 years before I ever got diagnosed.

Here is lyme doc, Dr. C, from his "explanation of the Western Blot" talking about the IgG and IgM:

"With most infections, your immune system first forms IgM antibodies, then in about 2 to 4 weeks, you see IgG antibodies. In some infections, IgG antibodies may be detectable for years.

Because Borrelia burgdorferi is a chronic persistent infection that may last for decades, you would think patients with chronic symptoms would have positive IgG Western blots.

But actually, more IgM blots are positive in chronic borreliosis than IgG. Every time Borrelia burgdorferi reproduces itself, it may stimulate the immune system to form new IgM antibodies.

Some patients have both IgG and IgM blots positive. But if either the IgG or IgM blot is positive, overall it is a positive result.

Response to antibiotics is the same if either is positive, or both. Some antibodies against the borrelia are given more significance if they are IgG versus IgM, or vice versa.

Since this is a chronic persistent infection, this does not make a lot of sense to me. A newly formed Borrelia burgdorferi should have the same antigen parts as the previous bacteria that produced it.

But anyway, from my clinical experience, these borrelia associated bands usually predict a clinical change in symptoms with antibiotics, regardless of whether they are IgG or IgM."

http://flash.lymenet.org/ubb/ultimatebb.php/topic/1/42077

So, as you can see, with lyme, IgG and IgM are meaningless. They both indicate exposure to lyme, but they do NOT tell you anything about how recent the exposure was.

Posts: 9931 | From Maryland | Registered: Dec 2007  |  IP: Logged | Report this post to a Moderator
Lymetoo
Moderator
Member # 743

Icon 1 posted      Profile for Lymetoo     Send New Private Message       Edit/Delete Post   Reply With Quote 
TF and Dr C are correct .. The main thing is to begin your search for an LLMD. Band 39 is very specific to Lyme.

--------------------
--Lymetutu--
Opinions, not medical advice!

Posts: 96013 | From Texas | Registered: Feb 2001  |  IP: Logged | Report this post to a Moderator
   

Quick Reply
Message:

HTML is not enabled.
UBB Code is enabled.

Instant Graemlins
   


Post New Topic  New Poll  Post A Reply Close Topic   Feature Topic   Move Topic   Delete Topic next oldest topic   next newest topic
 - Printer-friendly view of this topic
Hop To:


Contact Us | LymeNet home page | Privacy Statement

Powered by UBB.classic™ 6.7.3


The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:

The Lyme Disease Network of New Jersey
907 Pebble Creek Court, Pennington, NJ 08534 USA


| Flash Discussion | Support Groups | On-Line Library
Legal Resources | Medical Abstracts | Newsletter | Books
Pictures | Site Search | Links | Help/Questions
About LymeNet | Contact Us

© 1993-2020 The Lyme Disease Network of New Jersey, Inc.
All Rights Reserved.
Use of the LymeNet Site is subject to Terms and Conditions.