The combined effects of all-trans-retinoic acid and docosahexaenoic acid on the induction of apoptosis in human breast cancer MCF-7 cells.
CONCLUSION:
We conclude that the
combination of ATRA and DHA at the well-balanced proportion
***may be effective in cancer cell apoptosis.***
Further studies provide details about the potential synergistically effects of combination treatment of ATRA and DHA in growth inhibition and differentiation of human mammary cancer cells.
The WFL while hunting for food at night loves (and needs) to eat crickets. Crickets contain a lot of critical nutrients that activate rhodopsin in eye rods in order to see at night. When Bb loaded ticks feed on that lizard, Bb is killed.
"Crickets are also important sources of numerous necessary nutrients such as the 8 essential amino acids, vitamin B12, riboflavin,
***Vitamin A activates rhodopsin*** and sensitizes it to ultraviolet light.
PMID: 22192505
Repeating...crickets contain vitamin A nutrients required to activate rhodopsin so the WFL can see in the dark (rhodopsin captures any available light photons).
The chromophore imparting a
*** red color to rhodopsin***
was a vitamin A-derived compound called 11-cis-retinal.
Moreover, he found photons striking this chromophore could induce a change in its configuration from an 11-cis, through a series of photointermediates,
***to an all-trans state...***
(Rhodopsin + light-photons = "all trans" = ATRA)
Retinol is produced in the retina from Vitamin A, from dietary beta-carotene.
Isomerization of 11-cis-retinal ***into all-trans-retinal by light **** induces a conformational change (bleaching) in opsin,
continuing with metarhodopsin II,
which activates the associated G protein transducin
and triggers a Cyclic Guanosine Monophosphate, second messenger, cascade…
Wiki
Metarhodopsin II activates the G protein transducin (Gt) to activate the visual phototransduction pathway.
When transducin's α subunit is bound to GTP, it activates cGMP phosphodiesterase.
cGMP phosphodiesterase hydrolyzes cGMP
***(breaks it down).***
cGMP can no longer activate cation channels
The "English" translation =
The WFL's diet of crickets contains a lot of active vitamin A which activates rhodopsin which captures light photons -> ATRA -> metarhodopsin II -> transducin -> cGMP phosphodiesterase =
Degradation of cGMP causes
sodium channels to close!!! Wikipedia.
The above is how, I think, the WFL is capable of destroying Bb.
Bb is very, very dependent on Na - sodium:
The authors discussed that this spectrum of attractants/repellents, in addition to the fact that
NaCl was needed for motility, makes
it likely that B. burgdorferi uses chemotaxis to direct its movement through tissues.
The physiological conditions of the interstitial fluid meet the requirements for B.
"Along with this are secondary effects due to the gram negative nature of Bb bacteria. Gram negative bacteria have a lipopolysaccharide cell wall “LPS”.
The LPS are neurotoxins which have a low molecular weight which affect the whole body through the following mechanisms:
1. Disrupts sodium and calcium channel receptors
2. Attacks enzyme reactions involving glucose processing at the cellular level
4. Stimulates phospholipase A2 (PLA2) which prematurely uncouples essential fatty acids from cell membranes
***5. Impairs the function of PPAR gamma which affects changes in DNA function and gene switching.*** - from The Detoxx Book by John Foster M.D. et al."
posted
Have you heard of Dr. Morse in Port Charlotte?
Posts: 254 | From Westchester, NY | Registered: Jun 2009
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bluelyme
Frequent Contributor (1K+ posts)
Member # 47170
posted
I love how your brain works marnie , georgia hunter on hw and you could be a force to be reconed with ...i was always wondering about my photosensitivity and that info about wfl maybbe spot on ..just amazing .thank you
posted
Very interesting. Noni juice and grapeseed extract also fight MMP9 inflammation.
Posts: 13116 | From San Francisco | Registered: May 2006
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