posted
Probably so. By day 2 or 3 though I crash bad. I've never had a bad Candida herx like other people talk about and I take gobs of diflucan. Guess we're all different though!
Posts: 748 | From Texas | Registered: Feb 2015
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Jordana
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If you're crashing after three days it's probably not Lyme you're dealing with -- at least according to Burrascano. They don't replicate very fast. when they're metabolically active, that's when they replicate and whatever is working in your immune system responds.
A three day crash is more likely Bart. Bactrim could be controlling it.
I'm nervous about being off Bactrim, that stuff is my jam. Posts: 2057 | From Florida | Registered: Feb 2015
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posted
Yeah I agree with you. I say Lyme but I really mean "the undetermined infection". Amoxil kills whatever it is so maybe not Bart.
I started taking bactrim again too. Not sure if I'll stay on it or switch it to mino.
Did you know Bactrim is a glutathione precursor? Built-in detox! I love bactrim.
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TNT
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I'm normally not up like this anymore, but tonight I can't sleep.
SickSam, do you have references for that? I didn't know Bactrim is a glutathione precursor. I'm glad it helps you.
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Jordana
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No I did not know that! So confusing -- I thought it blocked folate, which is also a glutathione precursor?
We need a Lyme University.
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posted
Ugh, can't find the reference at the moment, sorry! I'll look more tomorrow.
At one point I had speculated that the sulfa was assisting with detox and potentially healing, so I started researching and found that trimethoprim metabolites are actually glutathione precursors. I was really surprised.
Hopefully I can find it for you all tomorrow.
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When it says the trimethoprim metabolites are glutathione adducts, I think it's saying trimethoprim combined with glutathione to create the metabolites. I originally read it as if the metabolites were precursors to glutathione.
Read it and see if my new understanding is right. I think my Lyme brain made a mistake. Sorry about that. ):
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Jordana
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Oh well . It's still my favorite drug.
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Phoiph
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FYI...in some cases, the positive "results" some may feel from antibiotics may result from their anti-inflammatory and/or immune modulating properties, not necessarily because of pathogen destruction:
TNT
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posted
No, I think you are right, SickSam. The wording definitely gives that impression. At least the way my small brain is reading it.
Your Rxlist.com article says:
"Trimethoprim is metabolized in vitro to 11 different metabolites, of which, five are glutathione adducts and six are oxidative metabolites, including the major metabolites, 1- and 3-oxides and the 3- and 4-hydroxy derivatives."
So, basically a product. It looks like at least the Trimethoprim part of Bactrim metabolizes to at least 5 different glutathione products and 6 oxidative ones.
Intriguing.
It does block the folate pathway, and that is why it has antimicrobial properties since some microbes need to synthesize folate to reproduce. That is also why humans need to supplement with folate when taking Bactrim. But, since we get our folate from our diet and don't synthesize it, the antifolates don't affect us AS MUCH.
When it says "five [metabolites] are glutathione adducts", breaking down the sentence structure to its core, it says "[metabolites] are adducts".
If the metabolites are adducts, that means the metabolites are the end products of a process/reaction. The modifier "glutathione" may mean that glutathione is used in the creation of the adduct.
So maybe: trimethoprim + glutathione = adduct
I could be wrong. I understood it just like you are saying the first time I read it. When I looked at it closer though, this is what I got.
Whatever the case, Bactrim has helped me feel better at times. (:
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TNT
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Yeah, you're probably right. It sounds too good to be true that an antibiotic could actually increase glutathione. Especially if it's inhibiting a cofactor's pathway.
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bluelyme
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Diflucan has fluoride in it ...and block cp450 ...maybe your liver likes it (not) ..can you get glutiothione ?
-------------------- Blue Posts: 1539 | From southwest | Registered: Dec 2015
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Jordana
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I don't do well on G. But I don't think the fluoride is a problem, I never touch anything else that's fluoridated.
Unless I'm revisiting a floxing? Which would be extremely unfortunate but it would also be really weird.
I think my liver is just attempting to process lots of fungus.
I hope that's all it is, crikey.
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I was concerned about the fluoride in Diflucan, however, the fluoride is molecularly bound and a very large majority of the drug is excreted unchanged in the urine.
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Jordana
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Thanks for that, Badtick. I did a quick check on floxing websites and it seems like floxies are tolerating it. And they barely tolerate anything especially at first.
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