Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
VERY INTERESTING! And for those like me who will have to look up the big words- a quick overview...
Baicalein (5,6,7 trihydroxyflavone) is a component of the traditional herbal remedy known as Chinese skullcap (or Huang Qin).
Luteolin is a flavonoid, and more precisely one of the citrus bioflavonoids.
Monolaurin is a 12-carbon long fatty acid, derived from coconut oil but prepared into a mono-ester of lauric acid.
cis-2-Decenoic acid is a fatty acid made by Pseudomonas aeruginosa. It could be used to fight again Biofilm implied in infectious diseases.
Rosmarinic Acid is a polyphenol similar to caffeic acid (found in coffee) and is in high levels in Perilla Oil and Rosemary, from which it draws its name.
Reciprocal cooperation of phytochemicals and micronutrients against typical and atypical forms of Borrelia spp.
Goc A1, Niedzwiecki A1, Rath M1.
Author information
1 Dr. Rath Research Institute BV, Santa Clara, California, USA.
Abstract
Borrelia spp., a causative pathogenic factor of Lyme disease, has become a major public health threat.
Current treatments based on antibiotics often lead to relapse after their withdrawal.
Naturally derived substances that could work synergistically to display higher efficacy compared to the individual components may serve as a resource for the development of novel approaches to combat both active and latent forms of Borrelia spp.
METHODS AND RESULTS:
Using checkerboard assay, we investigated the anti-borreliae reciprocal cooperation of phytochemicals and micronutrients against two species of Borrelia selected as prevalent causes of Lyme disease in the US and Europe.
We tested 28 combinations of phytochemicals such as polyphenols (baicalein, luteolin, rosmarinic acids), fatty acids (monolaurin, cis-2-decenoic acid), and micronutrients (ascorbic acid, cholecalciferol, and iodine).
The results showed that the combinations of baicalein with luteolin as well as monolaurin with cis-2-decenoic acid expressed synergistic anti-spirochetal effects.
Moreover, baicalein and luteolin, when combined with rosmarinic acid or iodine, produced additive bacteriostatic and bactericidal effects against typical corkscrew motile spirochetes and persistent knob/round-shaped forms, respectively.
An additive anti-biofilm effect was noticed between baicalein with luteolin as well as monolaurin with cis-2-decenoic acid.
Finally, application of the combination of baicalein with luteolin increased cytoplasmic permeability of Borrelia spp. but did not cause DNA damage.
CONCLUSIONS:
These results show that a specific combination of flavones might play a supporting role in combating Borrelia spp. through either synergistic or additive anti-borreliae effects.
SIGNIFICANCE AND IMPACT OF STUDY:
Presented here in vitro results might help advancing our knowledge and improving the approach to target Borrelia spp.
This article is protected by copyright. All rights reserved.
The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:
The
Lyme Disease Network of New Jersey 907 Pebble Creek Court,
Pennington,
NJ08534USA http://www.lymenet.org/
UBBFriend: Email this page to someone!
Printer-friendly view of this topic